KEGG   ORTHOLOGY: K03989Help
Entry
K03989                      KO                                     

Name
C4
Definition
complement component 4
Pathway
Complement and coagulation cascades
Pertussis
Staphylococcus aureus infection
Systemic lupus erythematosus
Disease
H00080  
Systemic lupus erythematosus
H00102  
Classic complement pathway component defects
Brite
KEGG Orthology (KO) [BR:ko00001]
 Organismal Systems
  Immune system
   04610 Complement and coagulation cascades
    K03989  C4; complement component 4
 Human Diseases
  Immune diseases
   05322 Systemic lupus erythematosus
    K03989  C4; complement component 4
  Infectious diseases
   05133 Pertussis
    K03989  C4; complement component 4
   05150 Staphylococcus aureus infection
    K03989  C4; complement component 4
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of hepatic cells
   K03989  C4; complement component 4
  Exosomal proteins of other cancer cells
   K03989  C4; complement component 4
BRITE hierarchy
Genes
HSA: 
720(C4A) 721(C4B)
PTR: 
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
721200(C4A)
MCF: 
RRO: 
CJC: 
MMU: 
12268(C4b)
RNO: 
24233(C4a)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
481722(C4A)
AML: 
UMR: 
FCA: 
PTG: 
BTA: 
280678(C4A) 617696(C4A)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
445467(C4A)
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
GGA: 
MGP: 
APLA: 
TGU: 
GFR: 
FAB: 
PHI: 
CCW: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
394275(c4a)
XTR: 
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2395880
  Authors
Carroll MC, Fathallah DM, Bergamaschini L, Alicot EM, Isenman DE
  Title
Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.
  Journal
Proc Natl Acad Sci U S A 87:6868-72 (1990)
  Sequence
[hsa:720] [hsa:721]

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