KEGG   ORTHOLOGY: K03990Help
Entry
K03990                      KO                                     

Name
C3
Definition
complement component 3
Pathway
Phagosome
Complement and coagulation cascades
Pertussis
Legionellosis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Staphylococcus aureus infection
Tuberculosis
Kaposi's sarcoma-associated herpesvirus infection
Herpes simplex infection
Viral carcinogenesis
Systemic lupus erythematosus
Disease
H00102  
Classic complement pathway component defects
H00821  
Age-related macular degeneration
H01434  
Atypical hemolytic uremic syndrome (aHUS)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    K03990  C3; complement component 3
 Organismal Systems
  Immune system
   04610 Complement and coagulation cascades
    K03990  C3; complement component 3
 Human Diseases
  Cancers
   05203 Viral carcinogenesis
    K03990  C3; complement component 3
  Immune diseases
   05322 Systemic lupus erythematosus
    K03990  C3; complement component 3
  Infectious diseases
   05133 Pertussis
    K03990  C3; complement component 3
   05134 Legionellosis
    K03990  C3; complement component 3
   05150 Staphylococcus aureus infection
    K03990  C3; complement component 3
   05152 Tuberculosis
    K03990  C3; complement component 3
   05168 Herpes simplex infection
    K03990  C3; complement component 3
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K03990  C3; complement component 3
   05140 Leishmaniasis
    K03990  C3; complement component 3
   05142 Chagas disease (American trypanosomiasis)
    K03990  C3; complement component 3
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Opsonins
    K03990  C3; complement component 3
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other cancer cells
   K03990  C3; complement component 3
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta2 integrins
   CR3, Mac-1
    ITGB2; integrin beta 2
     K03990 C3; complement component 3
   p150/95
    ITGB2; integrin beta 2
     K03990 C3; complement component 3
BRITE hierarchy
Genes
HSA: 
718(C3)
PTR: 
455644(C3)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
703613(C3)
MCF: 
CSAB: 
RRO: 
RBB: 
CJC: 
SBQ: 
MMU: 
12266(C3)
RNO: 
24232(C3)
CGE: 
NGI: 
HGL: 
CCAN: 
OCU: 
TUP: 
CFA: 
476728(C3)
AML: 
UMR: 
FCA: 
PTG: 
AJU: 
BTA: 
280677(C3)
BOM: 
BIU: 
PHD: 
CHX: 
OAS: 
SSC: 
397072(C3)
CFR: 
CDK: 
BACU: 
LVE: 
ECB: 
EPZ: 
EAI: 
MYB: 
MYD: 
HAI: 
RSS: 
PALE: 
LAV: 
MDO: 
SHR: 
OAA: 
GGA: 
396370(C3)
MGP: 
CJO: 
APLA: 
ACYG: 
GFR: 
FAB: 
PHI: 
PMAJ: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
PSS: 
CMY: 
CPIC: 
ACS: 
PVT: 
PBI: 
GJA: 
XLA: 
XTR: 
NPR: 
DRE: 
30491(c3a.2) 321046(c3a.1) 494039(c3a.6) 565074(c3a.3)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
CIN: 
445694(c3-1)
SPU: 
373284(c3)
APLC: 
SKO: 
TUT: 
CRG: 
MYI: 
EPA: 
ADF: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2579379
  Authors
de Bruijn MH, Fey GH
  Title
Human complement component C3: cDNA coding sequence and derived primary structure.
  Journal
Proc Natl Acad Sci U S A 82:708-12 (1985)
DOI:10.1073/pnas.82.3.708
  Sequence
[hsa:718]
Reference
  Authors
Murray I, Kohl J, Cianflone K
  Title
Acylation-stimulating protein (ASP): structure-function determinants of cell surface binding and triacylglycerol synthetic activity.
  Journal
Biochem J 342 ( Pt 1):41-8 (1999)
DOI:10.1042/bj3420041
  Sequence
[hsa:718]

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