KEGG   ORTHOLOGY: K04346Help
Entry
K04346                      KO                                     

Name
GNA12
Definition
guanine nucleotide-binding protein subunit alpha-12
Pathway
MAPK signaling pathway
cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Vascular smooth muscle contraction
Long-term depression
Regulation of actin cytoskeleton
Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04072 Phospholipase D signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04071 Sphingolipid signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04022 cGMP - PKG signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 Organismal Systems
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  Nervous system
   04730 Long-term depression
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of hepatic cells
   K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 4 (G12/13)
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
BRITE hierarchy
Genes
HSA: 
2768(GNA12)
PTR: 
463234(GNA12)
PPS: 
100979605(GNA12)
GGO: 
101147243(GNA12)
PON: 
100173387(GNA12)
NLE: 
100591916(GNA12)
MCC: 
100429106(GNA12)
MCF: 
101867258(GNA12)
CSAB: 
103246857(GNA12)
RRO: 
104664964(GNA12)
CJC: 
100387912(GNA12)
SBQ: 
101042405(GNA12)
MMU: 
14673(Gna12)
RNO: 
81663(Gna12)
CGE: 
100760944(Gna12)
NGI: 
103748670(Gna12)
HGL: 
101697421(Gna12)
OCU: 
100347293(GNA12)
TUP: 
102501406(GNA12)
CFA: 
102154318(GNA12)
AML: 
100465369(GNA12)
UMR: 
103669942(GNA12)
FCA: 
101093316(GNA12)
PTG: 
102961052(GNA12)
BTA: 
515159(GNA12)
BOM: 
102265273(GNA12)
PHD: 
102322053(GNA12)
CHX: 
102185175(GNA12)
OAS: 
101111070(GNA12)
SSC: 
100525156(GNA12)
CFR: 
102524525(GNA12)
BACU: 
103009974(GNA12)
LVE: 
103069136(GNA12)
ECB: 
100060005(GNA12)
MYB: 
102260289(GNA12)
MYD: 
102763801(GNA12)
PALE: 
102891706(GNA12)
LAV: 
100676444(GNA12)
MDO: 
100010453(GNA12)
SHR: 
100916443(GNA12)
OAA: 
100082592(GNA12)
GGA: 
769924(GNA12)
MGP: 
100550659(GNA12)
CJO: 
107320696(GNA12)
APLA: 
101798445(GNA12)
TGU: 
100225137(GNA12)
GFR: 
102044790(GNA12)
FAB: 
101818259(GNA12)
PHI: 
102104762(GNA12)
CCW: 
104684810(GNA12)
FPG: 
101917262(GNA12)
FCH: 
102059010(GNA12)
CLV: 
102088372(GNA12)
AAM: 
106483939(GNA12)
ASN: 
102377286(GNA12)
AMJ: 
102559993(GNA12)
PSS: 
102445616(GNA12)
CMY: 
102931254(GNA12)
ACS: 
100564021(gna12)
PBI: 
103050241(GNA12)
GJA: 
DRE: 
503589(gna12a)
TRU: 
101078184(gna12)
TNG: 
MZE: 
101473086(gna12)
OLA: 
101166935(gna12)
XMA: 
SASA: 
LCM: 
102367557(GNA12)
CMK: 
103185131(gna12)
BFO: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD17672(Dsim_GD17672)
DWI: 
DYA: 
Dyak_GE22695(Dyak_cta)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
410906(GB12482) 727645
BIM: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
100862775(Galpha12)
PXY: 
API: 
PHU: 
DPX: 
ISC: 
CEL: 
CELE_F18G5.3(gpa-12)
CBR: 
CBG16182(Cbr-gpa-12)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
NVE: 
ADF: 
HMG: 
100192290(gna12)
TAD: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Milligan G, Kostenis E
  Title
Heterotrimeric G-proteins: a short history.
  Journal
Br J Pharmacol 147 Suppl 1:S46-55 (2006)
Reference
  Authors
Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, Alessi D, Offermanns S, Simon MI, Wu D
  Title
PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12.
  Journal
Nat Cell Biol 14:686-96 (2012)
  Sequence
[hsa:2768]

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