KEGG   ORTHOLOGY: K04354Help
Entry
K04354                      KO                                     

Name
PPP2R2
Definition
serine/threonine-protein phosphatase 2A regulatory subunit B
Pathway
mRNA surveillance pathway
Sphingolipid signaling pathway
Cell cycle - yeast
PI3K-Akt signaling pathway
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Hippo signaling pathway
Hippo signaling pathway - fly
Tight junction
Dopaminergic synapse
Chagas disease (American trypanosomiasis)
Hepatitis C
Human papillomavirus infection
Disease
H00063  
Spinocerebellar ataxia (SCA)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Translation
   03015 mRNA surveillance pathway
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
 Environmental Information Processing
  Signal transduction
   04390 Hippo signaling pathway
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
   04391 Hippo signaling pathway -fly
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
   04071 Sphingolipid signaling pathway
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
   04151 PI3K-Akt signaling pathway
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
   04152 AMPK signaling pathway
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
 Cellular Processes
  Cell growth and death
   04111 Cell cycle - yeast
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
  Cellular community - eukaryotes
   04530 Tight junction
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
 Organismal Systems
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
  Nervous system
   04728 Dopaminergic synapse
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
 Human Diseases
  Infectious diseases
   05160 Hepatitis C
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
   05165 Human papillomavirus infection
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
   05142 Chagas disease (American trypanosomiasis)
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-2 (PP2A)
    Regulatory subunits
     K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
Chromosome [BR:ko03036]
 Eukaryotic Type
  Centromeric chromatin formation proteins
   Other centromeric chromatin formation proteins
    PP2A (protein phosphatase 2A)
     K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
5520(PPP2R2A) 5521(PPP2R2B) 5522(PPP2R2C) 55844(PPP2R2D)
PTR: 
461101(PPP2R2C) 462170(PPP2R2B) 464068(PPP2R2A) 466265(PPP2R2D)
PPS: 
100968814(PPP2R2D) 100983884(PPP2R2C) 100990236(PPP2R2B) 100991998(PPP2R2A)
GGO: 
101129571(PPP2R2A) 101132841(PPP2R2D) 101135043(PPP2R2B) 101140471(PPP2R2C)
PON: 
100174027(PPP2R2B) 100436819(PPP2R2D) 100443527(PPP2R2A)
NLE: 
100583131(PPP2R2C) 100583311(PPP2R2A) 100584267(PPP2R2B) 100585667(PPP2R2D)
MCC: 
699520(PPP2R2D) 706988(PPP2R2B) 711023(PPP2R2C) 711920(PPP2R2A)
MCF: 
101926197(PPP2R2A) 101926525(PPP2R2C) 102125257(PPP2R2B) 102142696(PPP2R2D)
CSAB: 
103215510(PPP2R2A) 103216725(PPP2R2D) 103244749(PPP2R2B) 103246406(PPP2R2C)
RRO: 
104659744(PPP2R2D) 104667559(PPP2R2C) 104673955(PPP2R2A) 104678160(PPP2R2B)
CJC: 
100385385(PPP2R2D) 100386371(PPP2R2C) 100407485(PPP2R2A) 100407627(PPP2R2B)
SBQ: 
101031700(PPP2R2C) 101038903(PPP2R2D) 101052911(PPP2R2B) 101054317(PPP2R2A)
MMU: 
269643(Ppp2r2c) 52432(Ppp2r2d) 71978(Ppp2r2a) 72930(Ppp2r2b)
RNO: 
117104(Ppp2r2a) 117256(Ppp2r2c) 246255(Ppp2r2d) 60660(Ppp2r2b)
CGE: 
100750924(Ppp2r2c) 100758873(Ppp2r2a) 100763205(Ppp2r2b) 100774343(Ppp2r2d)
NGI: 
103724526(Ppp2r2b) 103725821(Ppp2r2d) 103732390(Ppp2r2a) 103750638(Ppp2r2c)
HGL: 
101700573(Ppp2r2b) 101708645(Ppp2r2a) 101709789(Ppp2r2d) 101711517(Ppp2r2c)
CCAN: 
109684624(Ppp2r2b) 109687460(Ppp2r2c) 109694061(Ppp2r2a) 109698633(Ppp2r2d)
OCU: 
100009139(PPP2R2B) 100328616(PPP2R2A) 100328617(PPP2R2C) 100348286
TUP: 
102470174(PPP2R2C) 102480799(PPP2R2D) 102485560(PPP2R2B) 102488546(PPP2R2A)
CFA: 
477374(PPP2R2A) 478053(PPP2R2B) 491587(PPP2R2D) 610262(PPP2R2C)
AML: 
100469264(PPP2R2C) 100478681(PPP2R2B) 100480910(PPP2R2A) 100481821(PPP2R2D)
UMR: 
103658340(PPP2R2C) 103658377(PPP2R2D) 103663691(PPP2R2B) 103673291(PPP2R2A)
FCA: 
101084083(PPP2R2B) 101086093(PPP2R2D) 101091784(PPP2R2C) 101099546(PPP2R2A)
PTG: 
102949872(PPP2R2D) 102951261(PPP2R2B) 102952971(PPP2R2A) 102970289(PPP2R2C)
AJU: 
106966536(PPP2R2A) 106982732(PPP2R2C) 106984955(PPP2R2B) 106985785(PPP2R2D)
BTA: 
508045(PPP2R2A) 509290(PPP2R2B) 782110(PPP2R2C)
BOM: 
102272209(PPP2R2C) 102287363(PPP2R2B) 102287455(PPP2R2A) 102287482(PPP2R2D)
BIU: 
109560078(PPP2R2C) 109562172(PPP2R2B) 109563149(PPP2R2A) 109579044(PPP2R2D)
PHD: 
102323130(PPP2R2A) 102338279(PPP2R2B) 102338662(PPP2R2C)
CHX: 
102170971(PPP2R2B) 102181952(PPP2R2A) 102188298(PPP2R2C)
OAS: 
101102148(PPP2R2C) 101110299(PPP2R2A) 101113409(PPP2R2B)
SSC: 
100737053(PPP2R2C) 397089(PPP2R2B) 397090(PPP2R2A)
CFR: 
102509034(PPP2R2C) 102514622(PPP2R2A) 102517457(PPP2R2B)
BACU: 
103001451(PPP2R2C) 103003377(PPP2R2B) 103015446(PPP2R2D) 103020854(PPP2R2A)
LVE: 
103070944(PPP2R2C) 103075527(PPP2R2B) 103085298(PPP2R2A) 103090378(PPP2R2D)
ECB: 
100051737(PPP2R2D) 100059955(PPP2R2A) 100060957(PPP2R2B) 100070133(PPP2R2C)
MYB: 
102238990(PPP2R2A) 102240425(PPP2R2B) 102243537(PPP2R2C) 102254637(PPP2R2D)
MYD: 
102756870(PPP2R2A) 102772844(PPP2R2B) 102773953(PPP2R2D) 102774976(PPP2R2C)
HAI: 
109374120(PPP2R2C) 109383556(PPP2R2D) 109391741(PPP2R2A) 109392769
RSS: 
109436369(PPP2R2A) 109440279 109440630 109445698(PPP2R2D) 109451141(PPP2R2B) 109456136(PPP2R2C)
PALE: 
102882824(PPP2R2A) 102888692(PPP2R2B) 102892945(PPP2R2C)
LAV: 
100666413(PPP2R2B) 100666680(PPP2R2D) 100668825(PPP2R2A) 100668890
MDO: 
100014202(PPP2R2C) 100018121(PPP2R2A) 100023749(PPP2R2B) 100023958
SHR: 
100922930(PPP2R2C) 100931978(PPP2R2A) 100933266(PPP2R2B) 100935274(PPP2R2D)
OAA: 
GGA: 
416350(PPP2R2B) 419523(PPP2R2A) 422858(PPP2R2C) 423970(PPP2R2D)
MGP: 
100539113(PPP2R2A) 100547840(PPP2R2D) 100549668(PPP2R2C)
CJO: 
107314026(PPP2R2C) 107316269(PPP2R2D) 107320040(PPP2R2B) 107323661(PPP2R2A)
APLA: 
101792196(PPP2R2A) 101797307(PPP2R2B) 101798527(PPP2R2D) 101801149(PPP2R2C)
TGU: 
100225233(PPP2R2B) 100225699(PPP2R2C) 100232829(PPP2R2A)
GFR: 
102032631(PPP2R2C) 102036955(PPP2R2D) 102037872(PPP2R2B) 102043663(PPP2R2A)
FAB: 
101810844(PPP2R2B) 101812324(PPP2R2A) 101814165(PPP2R2D) 101819160(PPP2R2C)
PHI: 
102105305(PPP2R2B) 102105717(PPP2R2C) 102107324(PPP2R2A) 102114376(PPP2R2D)
CCW: 
104689468(PPP2R2B) 104690747(PPP2R2C) 104694825(PPP2R2A) 104694957(PPP2R2D)
FPG: 
101921274(PPP2R2B) 101921738(PPP2R2D) 101921932(PPP2R2C) 101924330(PPP2R2A)
FCH: 
102047212(PPP2R2C) 102050344(PPP2R2A) 102050692(PPP2R2B) 102053115(PPP2R2D)
CLV: 
102090341(PPP2R2C) 102091831(PPP2R2B) 102094079(PPP2R2A) 102098008(PPP2R2D)
AAM: 
106487247(PPP2R2B) 106489262(PPP2R2D) 106494284(PPP2R2A) 106498740(PPP2R2C)
ASN: 
102374906(PPP2R2B) 102380229 102380791(PPP2R2C) 102385445(PPP2R2A)
AMJ: 
102559987(PPP2R2C) 102572311(PPP2R2A) 102574203(PPP2R2D) 102574435(PPP2R2B)
PSS: 
102449014(PPP2R2A) 102449572 102450062 102457546(PPP2R2B) 102461089(PPP2R2C)
CMY: 
102930979(PPP2R2D) 102931164(PPP2R2C) 102931325(PPP2R2A) 102938384(PPP2R2B)
CPIC: 
101935306(PPP2R2D) 101939506(PPP2R2B) 101951345(PPP2R2C) 101953574(PPP2R2A)
ACS: 
100555366(ppp2r2a) 100558872(ppp2r2c) 100563742(ppp2r2b) 100567969(ppp2r2d)
PBI: 
103049560(PPP2R2A) 103050725(PPP2R2C) 103055041(PPP2R2B) 103063571(PPP2R2D)
GJA: 
107108836(PPP2R2D) 107112470(PPP2R2B) 107118342 107121378(PPP2R2C) 107126265(PPP2R2A)
XLA: 
XTR: 
100490097(ppp2r2c) 101732844 448324(ppp2r2d) 496486(ppp2r2a) 549212(ppp2r2b)
DRE: 
100002802(ppp2r2ca) 327263(ppp2r2ab) 405816(ppp2r2d) 558752(ppp2r2aa) 558810(ppp2r2bb) 559392(ppp2r2cb)
IPU: 
TRU: 
TNG: 
LCO: 
MZE: 
OLA: 
XMA: 
CSEM: 
SASA: 
LCM: 
102350099(PPP2R2B) 102355760(PPP2R2C) 102362122(PPP2R2A) 102364042(PPP2R2D)
CMK: 
103177292(ppp2r2b) 103180386(ppp2r2d) 103181323(ppp2r2c) 103191459
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD20732(Dsim_GD20732)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
410604(twins)
BIM: 
BTER: 
SOC: 
AEC: 
PBAR: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
CEL: 
CBR: 
CBG03807(Cbr-sur-6)
NAI: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
OVI: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
ATH: 
AT1G17720(ATB_BETA) AT1G51690(B_ALPHA)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
GHI: 
EGR: 
GMX: 
PVU: 
VRA: 
VAR: 
CCAJ: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0101969.1(Lj0g3v0101969.1) Lj0g3v0101969.2(Lj0g3v0101969.2) Lj3g3v0300670.1(Lj3g3v0300670.1) Lj3g3v0301720.1(Lj3g3v0301720.1) Lj3g3v0301720.2(Lj3g3v0301720.2) Lj3g3v3464480.1(Lj3g3v3464480.1)
LANG: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
ZJU: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0001s20400g POPTR_0003s02900g POPTR_0006s24710g(POPTRDRAFT_1081434) POPTR_0015s09060g(POPTRDRAFT_575190) POPTR_0018s05050g(POPTRDRAFT_1105642)
VVI: 
SLY: 
SPEN: 
SOT: 
INI: 
SIND: 
BVG: 
NNU: 
OSA: 
4328769(OsJ_005772) 4341313 9270873(P0518F01.9)
DOSA: 
Os01t0600200-01(Os01g0600200) Os02t0224200-01(Os02g0224200) Os02t0617600-01(Os02g0617600) Os06t0563300-01(Os06g0563300)
OBR: 
BDI: 
ATS: 
ZMA: 
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
APRO: 
CME: 
GSL: 
SCE: 
YGL190C(CDC55)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0B04470(NCAS0B04470) NCAS_0B05510(NCAS0B05510)
NDI: 
NDAI_0B01910(NDAI0B01910) NDAI_0B02680(NDAI0B02680)
TPF: 
TPHA_0H00350(TPHA0H00350)
TBL: 
TBLA_0D02160(TBLA0D02160)
TDL: 
TDEL_0B04610(TDEL0B04610)
KAF: 
KAFR_0C02950(KAFR0C02950)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
CLU: 
CAUR: 
NCR: 
NCU09377(rgb-1)
NTE: 
NEUTE1DRAFT142725(NEUTE1DRAFT_142725)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
FVR: 
FOX: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
CFJ: 
ELA: 
SSL: 
BFU: 
MBE: 
PSCO: 
GLZ: 
ANI: 
AFM: 
AOR: 
AOR_1_1032174(AO090005000590)
ANG: 
ANI_1_942144(An16g07130)
AFV: 
ACT: 
NFI: 
PCS: 
PDP: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
MYCGRDRAFT_67389(MgPP2Aregb1)
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
TVS: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT83170(AGABI1DRAFT_83170)
ABV: 
AGABI2DRAFT136742(AGABI2DRAFT_136742)
CPUT: 
SLA: 
WSE: 
WIC: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
ECU: 
EIN: 
EHE: 
ERO: 
NCE: 
MBR: 
SRE: 
DDI: 
DPP: 
DFA: 
EHI: 
EHI_148170(1.t00140)
EDI: 
EIV: 
ACAN: 
TET: 
PTM: 
AAF: 
PIF: 
PSOJ: 
SPAR: 
EHX: 
GTT: 
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
TVA: 
GLA: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1849734
  Authors
Mayer RE, Hendrix P, Cron P, Matthies R, Stone SR, Goris J, Merlevede W, Hofsteenge J, Hemmings BA
  Title
Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform.
  Journal
Biochemistry 30:3589-97 (1991)
DOI:10.1021/bi00229a001
  Sequence
[hsa:5520 5521]
Reference
  Authors
Hu P, Yu L, Zhang M, Zheng L, Zhao Y, Fu Q, Zhao S
  Title
Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16.
  Journal
Genomics 67:83-6 (2000)
DOI:10.1006/geno.2000.6219
  Sequence
[hsa:5522]
Reference
  Authors
Chen HF, Lin LN, Chen YX, Wan JX, Luo J, Zhang CZ, Li XJ, Hu YM, Mai JR, Chen W, Lin ZN, Lin YC
  Title
Identification and functional analysis of variant haplotypes in the 5'-flanking region of protein phosphatase 2A-Bdelta gene.
  Journal
PLoS One 7:e35524 (2012)
DOI:10.1371/journal.pone.0035524
  Sequence
[hsa:55844]

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