KEGG   ORTHOLOGY: K04359Help
Entry
K04359                      KO                                     

Name
PDGFA
Definition
platelet-derived growth factor subunit A
Pathway
EGFR tyrosine kinase inhibitor resistance
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Phospholipase D signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
Regulation of actin cytoskeleton
HTLV-I infection
Pathways in cancer
Transcriptional misregulation in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Melanoma
Choline metabolism in cancer
Disease
H00015  
Malignant pleural mesothelioma
H00042  
Glioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04015 Rap1 signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04010 MAPK signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04072 Phospholipase D signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04151 PI3K-Akt signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04359  PDGFA; platelet-derived growth factor subunit A
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04359  PDGFA; platelet-derived growth factor subunit A
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04359  PDGFA; platelet-derived growth factor subunit A
   04540 Gap junction
    K04359  PDGFA; platelet-derived growth factor subunit A
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05231 Choline metabolism in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05202 Transcriptional misregulation in cancers
    K04359  PDGFA; platelet-derived growth factor subunit A
   05206 MicroRNAs in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05214 Glioma
    K04359  PDGFA; platelet-derived growth factor subunit A
   05218 Melanoma
    K04359  PDGFA; platelet-derived growth factor subunit A
   05215 Prostate cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
  Infectious diseases
   05166 HTLV-I infection
    K04359  PDGFA; platelet-derived growth factor subunit A
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04359  PDGFA; platelet-derived growth factor subunit A
Cytokines [BR:ko04052]
 PDGF family
  Cysteine-knot growth factors
   Subclass I
    K04359  PDGFA; platelet-derived growth factor subunit A
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Neural system
   Enzymatic CD
    PDGFRA; platelet-derived growth factor receptor, alpha polypeptide
     K04359 PDGFA; platelet-derived growth factor subunit A
    PDGFRB; platelet-derived growth factor receptor, beta polypeptide
     K04359 PDGFA; platelet-derived growth factor subunit A
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Growth factors/receptors
   K04359  PDGFA; platelet-derived growth factor subunit A
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
5154(PDGFA)
PTR: 
740202(PDGFA)
PPS: 
100991389(PDGFA)
GGO: 
PON: 
100440212(PDGFA)
NLE: 
100583683(PDGFA)
MCC: 
707725(PDGFA)
MCF: 
102126620(PDGFA)
CSAB: 
103246906(PDGFA)
RRO: 
104664975(PDGFA)
CJC: 
100412906(PDGFA)
SBQ: 
101034511(PDGFA)
MMU: 
18590(Pdgfa)
RNO: 
25266(Pdgfa)
CGE: 
100771503(Pdgfa)
NGI: 
103748699(Pdgfa)
HGL: 
101725739(Pdgfa)
OCU: 
100352388(PDGFA)
TUP: 
102499235(PDGFA)
CFA: 
491597(PDGFA)
AML: 
100473486(PDGFA)
UMR: 
103670054(PDGFA)
FCA: 
101087287(PDGFA)
BTA: 
505908(PDGFA)
BOM: 
102271219(PDGFA)
PHD: 
102338084(PDGFA)
CHX: 
102174268(PDGFA)
SSC: 
100519764(PDGFA)
CFR: 
102520052(PDGFA)
BACU: 
103005337(PDGFA)
LVE: 
103089216(PDGFA)
ECB: 
100055086(PDGFA)
MYB: 
102253551(PDGFA)
MYD: 
102762551(PDGFA)
PALE: 
102893670(PDGFA)
LAV: 
100675120(PDGFA)
MDO: 
100020951(PDGFA)
SHR: 
100924985(PDGFA)
OAA: 
100081033(PDGFA)
GGA: 
374196(PDGFA)
MGP: 
100545955(PDGFA)
CJO: 
107320713(PDGFA)
APLA: 
101803502(PDGFA)
TGU: 
100222155(PDGFA)
GFR: 
102032936(PDGFA)
FAB: 
101810376(PDGFA)
PHI: 
102099148(PDGFA)
CCW: 
FPG: 
101922505(PDGFA)
FCH: 
102059520(PDGFA)
CLV: 
102085857(PDGFA)
ASN: 
102386051(PDGFA)
AMJ: 
102568490(PDGFA)
PSS: 
102453111(PDGFA)
CMY: 
102936738(PDGFA)
ACS: 
100560004(pdgfa)
PBI: 
103066198(PDGFA)
GJA: 
107115509(PDGFA)
XLA: 
397765(pdgfa.S)
XTR: 
100038202(pdgfa)
DRE: 
103909601 378480(pdgfaa) 767790(pdgfab) 796490(pdgfbb)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
102352946(PDGFA)
CMK: 
SOC: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3422746
  Authors
Bonthron DT, Morton CC, Orkin SH, Collins T
  Title
Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing.
  Journal
Proc Natl Acad Sci U S A 85:1492-6 (1988)
  Sequence
[hsa:5154]
Reference
  Authors
Wu E, Palmer N, Tian Z, Moseman AP, Galdzicki M, Wang X, Berger B, Zhang H, Kohane IS
  Title
Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells.
  Journal
PLoS One 3:e3794 (2008)
  Sequence
[dre:386856]

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