KEGG   ORTHOLOGY: K04359Help
Entry
K04359                      KO                                     

Name
PDGFA
Definition
platelet-derived growth factor subunit A
Pathway
EGFR tyrosine kinase inhibitor resistance
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Phospholipase D signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
Jak-STAT signaling pathway
Regulation of actin cytoskeleton
HTLV-I infection
Pathways in cancer
Transcriptional misregulation in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Melanoma
Choline metabolism in cancer
Fluid shear stress and atherosclerosis
Disease
H00015  
Malignant pleural mesothelioma
H00042  
Glioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04015 Rap1 signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04010 MAPK signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04630 Jak-STAT signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04072 Phospholipase D signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04151 PI3K-Akt signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04359  PDGFA; platelet-derived growth factor subunit A
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04359  PDGFA; platelet-derived growth factor subunit A
   04540 Gap junction
    K04359  PDGFA; platelet-derived growth factor subunit A
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04359  PDGFA; platelet-derived growth factor subunit A
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05231 Choline metabolism in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05202 Transcriptional misregulation in cancers
    K04359  PDGFA; platelet-derived growth factor subunit A
   05206 MicroRNAs in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05214 Glioma
    K04359  PDGFA; platelet-derived growth factor subunit A
   05218 Melanoma
    K04359  PDGFA; platelet-derived growth factor subunit A
   05215 Prostate cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04359  PDGFA; platelet-derived growth factor subunit A
  Infectious diseases
   05166 HTLV-I infection
    K04359  PDGFA; platelet-derived growth factor subunit A
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04359  PDGFA; platelet-derived growth factor subunit A
Cytokines [BR:ko04052]
 PDGF family
  Cysteine-knot growth factors
   Subclass I
    K04359  PDGFA; platelet-derived growth factor subunit A
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Neural system
   Enzymatic CD
    PDGFRA; platelet-derived growth factor receptor, alpha polypeptide
     K04359 PDGFA; platelet-derived growth factor subunit A
    PDGFRB; platelet-derived growth factor receptor, beta polypeptide
     K04359 PDGFA; platelet-derived growth factor subunit A
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Growth factors/receptors
   K04359  PDGFA; platelet-derived growth factor subunit A
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
5154(PDGFA)
PTR: 
740202(PDGFA)
PPS: 
100991389(PDGFA)
GGO: 
101132059(PDGFA)
PON: 
100440212(PDGFA)
NLE: 
100583683(PDGFA)
MCC: 
707725(PDGFA)
MCF: 
102126620(PDGFA)
CSAB: 
103246906(PDGFA)
RRO: 
104664975(PDGFA)
RBB: 
108542315(PDGFA)
CJC: 
100412906(PDGFA)
SBQ: 
101034511(PDGFA)
MMU: 
18590(Pdgfa)
RNO: 
25266(Pdgfa)
CGE: 
100771503(Pdgfa)
NGI: 
103748699(Pdgfa)
HGL: 
101725739(Pdgfa)
CCAN: 
109684500(Pdgfa)
OCU: 
100352388(PDGFA)
TUP: 
102499235(PDGFA)
CFA: 
491597(PDGFA)
AML: 
100473486(PDGFA)
UMR: 
103670054(PDGFA)
FCA: 
101087287(PDGFA)
BTA: 
505908(PDGFA)
BOM: 
102271219(PDGFA)
BIU: 
109578611(PDGFA)
PHD: 
102338084(PDGFA)
CHX: 
102174268(PDGFA)
SSC: 
100519764(PDGFA)
CFR: 
102520052(PDGFA)
CDK: 
105102061(PDGFA)
BACU: 
103005337(PDGFA)
LVE: 
103089216(PDGFA)
ECB: 
100055086(PDGFA)
EPZ: 
103555992(PDGFA)
EAI: 
106834748(PDGFA)
MYB: 
102253551(PDGFA)
MYD: 
102762551(PDGFA)
HAI: 
109380137(PDGFA)
RSS: 
109455731(PDGFA)
PALE: 
102893670(PDGFA)
LAV: 
100675120(PDGFA)
MDO: 
100020951(PDGFA)
SHR: 
100924985(PDGFA)
OAA: 
100081033(PDGFA)
GGA: 
374196(PDGFA)
MGP: 
100545955(PDGFA)
CJO: 
107320713(PDGFA)
APLA: 
101803502(PDGFA)
ACYG: 
106033384(PDGFA)
TGU: 
100222155(PDGFA)
GFR: 
102032936(PDGFA)
FAB: 
101810376(PDGFA)
PHI: 
102099148(PDGFA)
PMAJ: 
107211209(PDGFA)
CCW: 
104685042(PDGFA)
FPG: 
101922505(PDGFA)
FCH: 
102059520(PDGFA)
CLV: 
102085857(PDGFA)
ASN: 
102386051(PDGFA)
AMJ: 
102568490(PDGFA)
PSS: 
102453111(PDGFA)
CMY: 
102936738(PDGFA)
CPIC: 
101940087(PDGFA)
ACS: 
100560004(pdgfa)
PVT: 
110090337(PDGFA)
PBI: 
103066198(PDGFA)
GJA: 
107115509(PDGFA)
XLA: 
108701573(pdgfa.L) 397765(pdgfa.S)
XTR: 
100038202(pdgfa)
NPR: 
108800714(PDGFA)
DRE: 
103909601 378480(pdgfaa) 767790(pdgfab) 796490(pdgfbb)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
104945697(pdgfa)
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
110169079(pdgfa)
SASA: 
ELS: 
SFM: 
LCM: 
102352946(PDGFA)
CMK: 
SOC: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3422746
  Authors
Bonthron DT, Morton CC, Orkin SH, Collins T
  Title
Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing.
  Journal
Proc Natl Acad Sci U S A 85:1492-6 (1988)
DOI:10.1073/pnas.85.5.1492
  Sequence
[hsa:5154]
Reference
  Authors
Wu E, Palmer N, Tian Z, Moseman AP, Galdzicki M, Wang X, Berger B, Zhang H, Kohane IS
  Title
Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells.
  Journal
PLoS One 3:e3794 (2008)
DOI:10.1371/journal.pone.0003794
  Sequence
[dre:386856]

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