KEGG   ORTHOLOGY: K04362Help
Entry
K04362                      KO                                     

Name
FGFR1, CD331
Definition
fibroblast growth factor receptor 1 [EC:2.7.10.1]
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Regulation of actin cytoskeleton
Pathways in cancer
Proteoglycans in cancer
Prostate cancer
Melanoma
Breast cancer
Central carbon metabolism in cancer
Disease
H00255  
Hypogonadotropic hypogonadism
H00443  
Osteoglophonic dysplasia (OD)
H00458  
Craniosynostosis
H00516  
Isolated orofacial clefts
H01207  
Trigonocephaly
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04015 Rap1 signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04010 MAPK signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04151 PI3K-Akt signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
  Cellular community
   04520 Adherens junction
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04550 Signaling pathways regulating pluripotency of stem cells
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05230 Central carbon metabolism in cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05205 Proteoglycans in cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05218 Melanoma
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05215 Prostate cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05224 Breast cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04362  FGFR1, CD331; fibroblast growth factor receptor 1
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  FGFR family [OT]
   K04362  FGFR1, CD331; fibroblast growth factor receptor 1
Enzyme-linked receptors [BR:ko01020]
 Receptor tyrosine kinases
  RTK class IV (FGF receptor family)
   K04362  FGFR1, CD331; fibroblast growth factor receptor 1
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class IV (FGF receptor family)
   K04362  FGFR1, CD331; fibroblast growth factor receptor 1
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Neural system
   5/2 subfamily
    NCAM; neural cell adhesion molecule
     K04362 FGFR1, CD331; fibroblast growth factor receptor 1
   6/5 subfamily
    L1CAM; L1 cell adhesion molecule
     K04362 FGFR1, CD331; fibroblast growth factor receptor 1
 5. Cadherin Family
  Classic Cadherins
   Vertebrate Type I classic cadherins
    CDH2; cadherin 2, type 1, N-cadherin
     K04362 FGFR1, CD331; fibroblast growth factor receptor 1
Cellular antigens [BR:ko04090]
 Proteins
  K04362  CD331, FGFR1; fibroblast growth factor receptor 1
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Growth factors/receptors
   K04362  FGFR1, CD331; fibroblast growth factor receptor 1
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
2260(FGFR1)
PTR: 
464122(FGFR1)
PPS: 
100988115(FGFR1)
GGO: 
101152179(FGFR1)
PON: 
100174545(FGFR1)
NLE: 
100602423(FGFR1)
MCC: 
700126(FGFR1)
MCF: 
102144714(FGFR1)
CSAB: 
103215648(FGFR1)
RRO: 
104679640(FGFR1)
CJC: 
100390192(FGFR1)
SBQ: 
101033213(FGFR1)
MMU: 
14182(Fgfr1)
RNO: 
79114(Fgfr1)
CGE: 
100773586(Fgfr1)
NGI: 
103745770(Fgfr1)
HGL: 
101700324(Fgfr1)
OCU: 
100351861(FGFR1)
TUP: 
102484087(FGFR1)
CFA: 
100856477(FGFR1)
AML: 
100472630(FGFR1)
UMR: 
103659146(FGFR1)
FCA: 
101086055(FGFR1)
PTG: 
102972346(FGFR1)
BTA: 
281768(FGFR1)
BOM: 
102267776(FGFR1)
PHD: 
102315245(FGFR1)
CHX: 
102180282(FGFR1)
OAS: 
780507(FGFR1)
SSC: 
100153248(FGFR1)
CFR: 
102515264(FGFR1)
BACU: 
103017733(FGFR1)
LVE: 
103069902(FGFR1)
ECB: 
100057614(FGFR1)
MYB: 
102253832(FGFR1)
MYD: 
102759202(FGFR1)
PALE: 
102898943(FGFR1)
LAV: 
100662289(FGFR1)
MDO: 
100029852(FGFR1)
SHR: 
100914347(FGFR1)
OAA: 
100074240(FGFR1)
GGA: 
396516(FGFR1)
MGP: 
100547498(FGFR1)
CJO: 
107323773(FGFR1)
APLA: 
101799290(FGFR1)
TGU: 
100221243(FGFR1)
GFR: 
FAB: 
101822220(FGFR1)
PHI: 
102103637(FGFR1)
CCW: 
104694904(FGFR1)
FPG: 
101914093(FGFR1)
FCH: 
102055369(FGFR1)
CLV: 
102085235(FGFR1)
AAM: 
106492992(FGFR1)
ASN: 
102386174(FGFR1)
AMJ: 
102574117(FGFR1)
PSS: 
102461506(FGFR1)
CMY: 
ACS: 
100559018(fgfr1)
PBI: 
103066603(FGFR1)
GJA: 
107113006(FGFR1)
XLA: 
397782(xfgfra2) 399444(fgfr1-b)
XTR: 
548648(fgfr1)
DRE: 
30705(fgfr1a)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
102361014(FGFR1)
CMK: 
BFO: 
CIN: 
445706(fgfr)
SPU: 
373310(FGFR)
SKO: 
AAG: 
NVI: 
API: 
DPX: 
TSP: 
HRO: 
LGI: 
OBI: 
ADF: 
AQU: 
SRE: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1697263
  Authors
Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J
  Title
Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.
  Journal
EMBO J 9:2685-92 (1990)
  Sequence
[hsa:2260]

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