KEGG   ORTHOLOGY: K04364Help
Entry
K04364                      KO                                     

Name
GRB2
Definition
growth factor receptor-binding protein 2
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
MAPK signaling pathway - fly
Ras signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Dorso-ventral axis formation
Osteoclast differentiation
Focal adhesion
Gap junction
Signaling pathways regulating pluripotency of stem cells
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Prolactin signaling pathway
Alcoholism
Hepatitis C
Hepatitis B
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Endometrial cancer
Glioma
Prostate cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04010 MAPK signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04013 MAPK signaling pathway - fly
    K04364  GRB2; growth factor receptor-binding protein 2
   04012 ErbB signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04630 Jak-STAT signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04068 FoxO signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04072 Phospholipase D signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04151 PI3K-Akt signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04150 mTOR signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04364  GRB2; growth factor receptor-binding protein 2
   04540 Gap junction
    K04364  GRB2; growth factor receptor-binding protein 2
   04550 Signaling pathways regulating pluripotency of stem cells
    K04364  GRB2; growth factor receptor-binding protein 2
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K04364  GRB2; growth factor receptor-binding protein 2
   04660 T cell receptor signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04662 B cell receptor signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04664 Fc epsilon RI signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04062 Chemokine signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
  Endocrine system
   04910 Insulin signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04912 GnRH signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04915 Estrogen signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04917 Prolactin signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
  Nervous system
   04722 Neurotrophin signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
  Development
   04320 Dorso-ventral axis formation
    K04364  GRB2; growth factor receptor-binding protein 2
   04380 Osteoclast differentiation
    K04364  GRB2; growth factor receptor-binding protein 2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04364  GRB2; growth factor receptor-binding protein 2
   05231 Choline metabolism in cancer
    K04364  GRB2; growth factor receptor-binding protein 2
   05206 MicroRNAs in cancer
    K04364  GRB2; growth factor receptor-binding protein 2
   05205 Proteoglycans in cancer
    K04364  GRB2; growth factor receptor-binding protein 2
   05203 Viral carcinogenesis
    K04364  GRB2; growth factor receptor-binding protein 2
   05214 Glioma
    K04364  GRB2; growth factor receptor-binding protein 2
   05221 Acute myeloid leukemia
    K04364  GRB2; growth factor receptor-binding protein 2
   05220 Chronic myeloid leukemia
    K04364  GRB2; growth factor receptor-binding protein 2
   05211 Renal cell carcinoma
    K04364  GRB2; growth factor receptor-binding protein 2
   05215 Prostate cancer
    K04364  GRB2; growth factor receptor-binding protein 2
   05213 Endometrial cancer
    K04364  GRB2; growth factor receptor-binding protein 2
   05224 Breast cancer
    K04364  GRB2; growth factor receptor-binding protein 2
   05223 Non-small cell lung cancer
    K04364  GRB2; growth factor receptor-binding protein 2
  Substance dependence
   05034 Alcoholism
    K04364  GRB2; growth factor receptor-binding protein 2
  Infectious diseases
   05161 Hepatitis B
    K04364  GRB2; growth factor receptor-binding protein 2
   05160 Hepatitis C
    K04364  GRB2; growth factor receptor-binding protein 2
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04364  GRB2; growth factor receptor-binding protein 2
   01522 Endocrine resistance
    K04364  GRB2; growth factor receptor-binding protein 2
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    K04364  GRB2; growth factor receptor-binding protein 2
BRITE hierarchy
Other DBs
Genes
HSA: 
2885(GRB2)
PTR: 
737245(GRB2)
PPS: 
100993451(GRB2)
GGO: 
101133976(GRB2)
PON: 
100173972(GRB2)
NLE: 
100588468(GRB2)
MCC: 
702041(GRB2) 702473(GRAP)
MCF: 
102118276(GRB2)
CSAB: 
103243048(GRB2)
RRO: 
104681311(GRB2)
CJC: 
100395682(GRB2)
SBQ: 
101038666(GRB2)
MMU: 
14784(Grb2)
RNO: 
81504(Grb2)
CGE: 
100769627(Grb2)
NGI: 
103732729(Grb2)
HGL: 
101717035(Grb2)
OCU: 
100342500(GRB2)
TUP: 
102493080(GRB2)
CFA: 
483312(GRB2)
AML: 
100468916(GRB2)
UMR: 
103665736(GRB2)
FCA: 
101099916(GRB2)
PTG: 
102970459(GRB2)
BTA: 
535298(GRB2)
BOM: 
102286241(GRB2)
PHD: 
102318888(GRB2)
CHX: 
102170356(GRB2)
OAS: 
101109893(GRB2)
SSC: 
100192436(GRB2)
CFR: 
102515306(GRB2)
BACU: 
103010512(GRB2)
LVE: 
103079766(GRB2)
ECB: 
100051866(GRB2)
MYB: 
102241832(GRB2)
MYD: 
102754991(GRB2)
PALE: 
102878822(GRB2)
LAV: 
100655474(GRB2)
MDO: 
100022894(GRB2)
SHR: 
100928380(GRB2)
OAA: 
100075806(GRB2) 100079295(GRAP)
GGA: 
386572(GRB2)
MGP: 
100541322(GRB2)
CJO: 
107322339(GRB2)
APLA: 
101797458(GRB2)
TGU: 
100190285(GRB2)
GFR: 
102038068(GRB2)
FAB: 
101812321(GRB2)
PHI: 
102101539(GRB2)
CCW: 
104694312(GRB2)
FPG: 
101913969(GRB2)
FCH: 
102057209(GRB2)
CLV: 
102098952(GRB2)
AAM: 
106485676(GRB2)
ASN: 
102376596(GRB2)
AMJ: 
102564907(GRB2) 102577011(GRAP)
PSS: 
102463609(GRB2)
CMY: 
102945306(GRB2)
ACS: 
100564375(grb2)
PBI: 
103062398(GRB2)
GJA: 
107110018(GRB2)
XLA: 
399458(grb2.L) 444095(grb2.S)
XTR: 
493492(grb2)
DRE: 
406308(grb2b) 493609(grb2a)
TRU: 
TNG: 
MZE: 
OLA: 
101160816(grb2)
XMA: 
102231736(grb2)
SASA: 
LCM: 
102353904(GRB2)
CMK: 
103175438(grb2)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
Dyak_GE13357(dyak_GLEANR_13576)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
550857(drk)
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
DPL: 
PXY: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG16856(Cbr-sem-5) CBG23363
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
ADF: 
HMG: 
AQU: 
SRE: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7689150
  Authors
Suen KL, Bustelo XR, Pawson T, Barbacid M
  Title
Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors.
  Journal
Mol Cell Biol 13:5500-12 (1993)
  Sequence
[mmu:14784]

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