KEGG   ORTHOLOGY: K04365Help
Entry
K04365                      KO                                     

Name
BRAF
Definition
B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Pathway
MAPK signaling pathway
ErbB signaling pathway
Rap1 signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
mTOR signaling pathway
Vascular smooth muscle contraction
Focal adhesion
Natural killer cell mediated cytotoxicity
Long-term potentiation
Neurotrophin signaling pathway
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Alcoholism
Hepatitis C
Pathways in cancer
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Disease
H00032  
Thyroid cancer
H00038  
Malignant melanoma
H00523  
Noonan syndrome and related disorders
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04010 MAPK signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04012 ErbB signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04068 FoxO signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04150 mTOR signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Cell communication
   04510 Focal adhesion
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04062 Chemokine signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Endocrine system
   04910 Insulin signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04914 Progesterone-mediated oocyte maturation
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Nervous system
   04726 Serotonergic synapse
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04720 Long-term potentiation
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04730 Long-term depression
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04722 Neurotrophin signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05205 Proteoglycans in cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05210 Colorectal cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05212 Pancreatic cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05214 Glioma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05216 Thyroid cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05221 Acute myeloid leukemia
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05220 Chronic myeloid leukemia
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05218 Melanoma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05211 Renal cell carcinoma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05219 Bladder cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05215 Prostate cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05213 Endometrial cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05223 Non-small cell lung cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Substance dependence
   05034 Alcoholism
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Infectious diseases
   05160 Hepatitis C
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: TKL group
  RAF family [OT]
   K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
BRITE hierarchy
Genes
HSA: 
673(BRAF)
PTR: 
463781(BRAF)
PPS: 
100971666(BRAF)
GGO: 
101145098(BRAF)
PON: 
100442288(BRAF)
MCC: 
MCF: 
MMU: 
109880(Braf)
RNO: 
114486(Braf)
CGE: 
100771486(Braf)
HGL: 
101702762(Braf)
TUP: 
102477389(BRAF)
CFA: 
475526(BRAF)
AML: 
100469346(BRAF)
FCA: 
101092346(BRAF)
PTG: 
102951082(BRAF)
BTA: 
536051(BRAF)
BOM: 
102278631(BRAF)
PHD: 
102329974(BRAF)
CHX: 
102174360(BRAF)
SSC: 
100514612(BRAF)
CFR: 
102524100(BRAF)
BACU: 
103002372(BRAF)
LVE: 
103079256(BRAF)
ECB: 
100065760(BRAF)
MYB: 
102260644(BRAF)
MYD: 
102760422(BRAF)
PALE: 
102878393(BRAF)
MDO: 
100024057(BRAF)
SHR: 
100934801(BRAF)
OAA: 
100086380(BRAF)
GGA: 
396239(BRAF)
MGP: 
TGU: 
100219601(BRAF)
FAB: 
101806469(BRAF)
PHI: 
102104959(BRAF)
APLA: 
101794380(BRAF)
FPG: 
101919653(BRAF)
FCH: 
102056938(BRAF)
CLV: 
102088487(BRAF)
ASN: 
102380007(BRAF)
AMJ: 
102576986(BRAF)
PSS: 
102448997(BRAF)
CMY: 
102938595(BRAF)
ACS: 
PBI: 
103054585(BRAF)
XLA: 
398973(braf) 447268(B-Raf)
XTR: 
779570(braf)
DRE: 
403065(braf)
TRU: 
653021(braf)
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103181856(braf)
CIN: 
778741(raf1)
SPU: 
575613(braf)
CEL: 
CBR: 
CBG05382(Cbr-lin-45)
BMY: 
LOA: 
NVE: 
HMG: 
TAD: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Roskoski R Jr
  Title
RAF protein-serine/threonine kinases: structure and regulation.
  Journal
Biochem Biophys Res Commun 399:313-7 (2010)

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