KEGG   ORTHOLOGY: K04365Help
Entry
K04365                      KO                                     

Name
BRAF
Definition
B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
MAPK signaling pathway - fly
Rap1 signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
mTOR signaling pathway
Apoptosis - fly
Vascular smooth muscle contraction
Dorso-ventral axis formation
Focal adhesion
Natural killer cell mediated cytotoxicity
Long-term potentiation
Neurotrophin signaling pathway
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Alcoholism
Hepatitis C
Pathways in cancer
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Module
M00687  
MAPK (ERK1/2) signaling
Disease
H00032  
Thyroid cancer
H00038  
Malignant melanoma
H00523  
Noonan syndrome and related disorders
H01512  
Langerhans cell histiocytosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04010 MAPK signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04013 MAPK signaling pathway - fly
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04012 ErbB signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04068 FoxO signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04024 cAMP signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04150 mTOR signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Cell growth and death
   04214 Apoptosis - fly
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04062 Chemokine signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Endocrine system
   04910 Insulin signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04914 Progesterone-mediated oocyte maturation
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Nervous system
   04726 Serotonergic synapse
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04720 Long-term potentiation
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04730 Long-term depression
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04722 Neurotrophin signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Development
   04320 Dorso-ventral axis formation
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05205 Proteoglycans in cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05210 Colorectal cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05212 Pancreatic cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05214 Glioma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05216 Thyroid cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05221 Acute myeloid leukemia
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05220 Chronic myeloid leukemia
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05218 Melanoma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05211 Renal cell carcinoma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05219 Bladder cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05215 Prostate cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05213 Endometrial cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05224 Breast cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05223 Non-small cell lung cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Substance dependence
   05034 Alcoholism
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Infectious diseases
   05160 Hepatitis C
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   01522 Endocrine resistance
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00687  MAPK (ERK1/2) signaling
     K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: TKL group
  RAF family [OT]
   K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
BRITE hierarchy
Genes
HSA: 
673(BRAF)
PTR: 
107971671(BRAF) 463781(BRAF)
PPS: 
100971666(BRAF)
GGO: 
101145098(BRAF)
PON: 
100442288(BRAF)
NLE: 
100582848(BRAF)
MCC: 
693554(BRAF)
MCF: 
101866436(BRAF)
CSAB: 
103227022(BRAF)
RRO: 
104659700(BRAF)
CJC: 
100403091(BRAF)
SBQ: 
101052142(BRAF)
MMU: 
109880(Braf)
RNO: 
114486(Braf)
CGE: 
100771486(Braf)
NGI: 
103726107(Braf)
HGL: 
101702762(Braf)
OCU: 
100351964(BRAF)
TUP: 
102477389(BRAF)
CFA: 
475526(BRAF)
AML: 
100469346(BRAF)
UMR: 
103669103(BRAF)
FCA: 
101092346(BRAF)
PTG: 
102951082(BRAF)
BTA: 
536051(BRAF)
BOM: 
102278631(BRAF)
PHD: 
102329974(BRAF)
CHX: 
102174360(BRAF)
OAS: 
101107438(BRAF)
SSC: 
100514612(BRAF)
CFR: 
102524100(BRAF)
BACU: 
103002372(BRAF)
LVE: 
103079256(BRAF)
ECB: 
100065760(BRAF)
MYB: 
102260644(BRAF)
MYD: 
102760422(BRAF)
PALE: 
102878393(BRAF)
LAV: 
100664119(BRAF)
MDO: 
100024057(BRAF)
SHR: 
100934801(BRAF)
OAA: 
100086380(BRAF)
GGA: 
396239(BRAF)
MGP: 
CJO: 
107315883(BRAF)
APLA: 
101794380(BRAF)
TGU: 
100219601(BRAF)
GFR: 
102032961(BRAF)
FAB: 
101806469(BRAF)
PHI: 
102104959(BRAF)
CCW: 
104696191(BRAF)
FPG: 
101919653(BRAF)
FCH: 
102056938(BRAF)
CLV: 
102088487(BRAF)
AAM: 
106488842(BRAF)
ASN: 
102380007(BRAF)
AMJ: 
106737102(BRAF)
PSS: 
102448997(BRAF)
CMY: 
102938595(BRAF)
ACS: 
100556317(braf)
PBI: 
103054585(BRAF)
GJA: 
107108795(BRAF)
XLA: 
398973(braf.S) 447268(B-Raf)
XTR: 
779570(braf)
DRE: 
403065(braf)
TRU: 
653021(braf)
TNG: 
MZE: 
101476445(braf)
OLA: 
101155814(braf)
XMA: 
102231368(braf)
SASA: 
LCM: 
CMK: 
103181856(braf)
CIN: 
778741(raf1)
SPU: 
575613(braf)
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
Dyak_GE16257(dyak_GLEANR_17697)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
413448(Raf1)
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
655334(raf)
BMOR: 
DPL: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
CEL: 
CBR: 
CBG05382(Cbr-lin-45)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
MDM: 
CPUT: 
SLA: 
SMIN: 
v1.2.019335.t1(symbB.v1.2.019335.t1)
SPAR: 
GTT: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2284096
  Authors
Sithanandam G, Kolch W, Duh FM, Rapp UR
  Title
Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies.
  Journal
Oncogene 5:1775-80 (1990)
  Sequence
[hsa:673]
Reference
  Authors
Brennan DF, Dar AC, Hertz NT, Chao WC, Burlingame AL, Shokat KM, Barford D
  Title
A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.
  Journal
Nature 472:366-9 (2011)
  Sequence
[hsa:673]

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