KEGG   ORTHOLOGY: K04374Help
Entry
K04374                      KO                                     

Name
ATF4, CREB2
Definition
cyclic AMP-dependent transcription factor ATF-4
Pathway
MAPK signaling pathway
cGMP-PKG signaling pathway
Protein processing in endoplasmic reticulum
PI3K-Akt signaling pathway
Apoptosis
Longevity regulating pathway
Longevity regulating pathway - worm
Apoptosis - fly
Adrenergic signaling in cardiomyocytes
TNF signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Cholinergic synapse
Dopaminergic synapse
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Thyroid hormone synthesis
Glucagon signaling pathway
Aldosterone synthesis and secretion
Non-alcoholic fatty liver disease (NAFLD)
Cocaine addiction
Amphetamine addiction
Alcoholism
Hepatitis B
HTLV-I infection
Viral carcinogenesis
Prostate cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04668 TNF signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04022 cGMP - PKG signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04151 PI3K-Akt signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04214 Apoptosis - fly
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04922 Glucagon signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04912 GnRH signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04915 Estrogen signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04918 Thyroid hormone synthesis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04925 Aldosterone synthesis and secretion
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  Nervous system
   04725 Cholinergic synapse
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04728 Dopaminergic synapse
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04720 Long-term potentiation
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04722 Neurotrophin signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  Aging
   04211 Longevity regulating pathway - mammal
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04212 Longevity regulating pathway - worm
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 Human Diseases
  Cancers
   05203 Viral carcinogenesis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05215 Prostate cancer
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  Substance dependence
   05030 Cocaine addiction
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05031 Amphetamine addiction
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05034 Alcoholism
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  Infectious diseases
   05166 HTLV-I infection
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05161 Hepatitis B
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
Transcription factors [BR:ko03000]
 Eukaryotic Type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, CRE-BP/ATF
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
468(ATF4)
PTR: 
744513(ATF4)
PPS: 
100988487(ATF4)
GGO: 
101139584(ATF4)
PON: 
100462459(ATF4)
NLE: 
MCC: 
703965(ATF4)
MCF: 
102117938(ATF4)
RRO: 
104682563(ATF4)
CJC: 
100392193(ATF4)
MMU: 
11911(Atf4)
RNO: 
79255(Atf4)
CGE: 
100689386(Atf4)
NGI: 
103748563(Atf4)
HGL: 
101724287(Atf4)
OCU: 
100339383(ATF4)
TUP: 
102478154(ATF4)
CFA: 
474503(ATF4)
AML: 
100476284(ATF4)
UMR: 
103676372(ATF4)
FCA: 
101084297(ATF4)
PTG: 
102950077(ATF4)
BTA: 
509107(ATF4)
BOM: 
102267423(ATF4)
PHD: 
102316221(ATF4)
CHX: 
102185072(ATF4)
OAS: 
100216465(ATF4)
SSC: 
100144302(ATF4)
CFR: 
102508076(ATF4)
BACU: 
103017770(ATF4)
LVE: 
103083306(ATF4)
ECB: 
100070334(ATF4)
MYB: 
102238786(ATF4)
MYD: 
102763654(ATF4)
PALE: 
102896553(ATF4)
MDO: 
100012224(ATF4)
SHR: 
100913697(ATF4)
OAA: 
100089902(ATF4)
GGA: 
395693(ATF4)
MGP: 
100550984(ATF4)
CJO: 
107312723(ATF4)
APLA: 
101800475(ATF4)
TGU: 
100190733(ATF4)
GFR: 
102036875(ATF4)
FAB: 
101814204(ATF4)
PHI: 
102100681(ATF4)
CCW: 
104696333(ATF4)
FPG: 
101921834(ATF4)
FCH: 
102049324(ATF4)
CLV: 
102093872(ATF4)
AAM: 
106488703(ATF4)
ASN: 
102369745(ATF4)
AMJ: 
102564186(ATF4)
PSS: 
102449551(ATF4)
CMY: 
102941988(ATF4)
ACS: 
100565177(atf4)
PBI: 
103055721(ATF4)
GJA: 
107117129(ATF4)
XLA: 
398804(atf4-a) 734165(atf4-b)
XTR: 
448005(atf4)
DRE: 
406514(atf4a) 556410(atf4b)
TRU: 
MZE: 
OLA: 
101168714(atf4-2) 101172388(atf4)
XMA: 
LCM: 
102365086(ATF4)
CMK: 
BFO: 
CIN: 
778545(atf4/5)
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD24316(Dsim_GD24316)
DWI: 
DYA: 
Dyak_GE12912(dyak_GLEANR_13126)
DGR: 
DMO: 
DVI: 
MDE: 
AAG: 
CQU: 
AME: 
410226(crc)
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
658480(ATF4)
BMOR: 
692594(Atf)
API: 
ISC: 
CEL: 
CBR: 
CBG07594(Cbr-atf-5)
BMY: 
LOA: 
HRO: 
LGI: 
CRG: 
OBI: 
HMG: 
TAD: 
AQU: 
DOSA: 
Os01t0211800-01(Os01g0211800)
MUS: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Ameri K, Harris AL
  Title
Activating transcription factor 4.
  Journal
Int J Biochem Cell Biol 40:14-21 (2008)
Reference
  Authors
Mayr B, Montminy M
  Title
Transcriptional regulation by the phosphorylation-dependent factor CREB.
  Journal
Nat Rev Mol Cell Biol 2:599-609 (2001)
Reference
  Authors
Sayer JA, Otto EA, O'Toole JF, Nurnberg G, Kennedy MA, Becker C, Hennies HC, Helou J, Attanasio M, Fausett BV, Utsch B, Khanna H, Liu Y, Drummond I, Kawakami I, Kusakabe T, Tsuda M, Ma L, Lee H, Larson RG, Allen SJ, Wilkinson CJ, Nigg EA, Shou C, Lillo C, Williams DS, Hoppe B, Kemper MJ, Neuhaus T, Parisi MA, Glass IA, Petry M, Kispert A, Gloy J, Ganner A, Walz G, Zhu X, Goldman D, Nurnberg P, Swaroop A, Leroux MR, Hildebrandt F
  Title
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4.
  Journal
Nat Genet 38:674-81 (2006)
  Sequence
[hsa:468]

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