KEGG ORTHOLOGY: K04374

ORTHOLOGY: K04374

Entry

K04374 KO

Name

ATF4, CREB2

Definition

cyclic AMP-dependent transcription factor ATF-4

Pathway

ko04010	MAPK signaling pathway
ko04141	Protein processing in endoplasmic reticulum
ko04151	PI3K-Akt signaling pathway
ko04720	Long-term potentiation
ko04722	Neurotrophin signaling pathway
ko04725	Cholinergic synapse
ko04728	Dopaminergic synapse
ko04911	Insulin secretion
ko04912	GnRH signaling pathway
ko04915	Estrogen signaling pathway
ko05030	Cocaine addiction
ko05031	Amphetamine addiction
ko05034	Alcoholism
ko05161	Hepatitis B
ko05166	HTLV-I infection
ko05203	Viral carcinogenesis
ko05215	Prostate cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04151 PI3K-Akt signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
Organismal Systems
  Endocrine system
   04911 Insulin secretion
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04912 GnRH signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04915 Estrogen signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  Nervous system
   04725 Cholinergic synapse
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04728 Dopaminergic synapse
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04720 Long-term potentiation
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04722 Neurotrophin signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
Human Diseases
  Cancers
   05203 Viral carcinogenesis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05215 Prostate cancer
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  Substance dependence
   05030 Cocaine addiction
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05031 Amphetamine addiction
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05034 Alcoholism
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  Infectious diseases
   05166 HTLV-I infection
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05161 Hepatitis B
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
Transcription factors [BR:ko03000]
Eukaryotic Type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, CRE-BP/ATF
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4

Other DBs

GO:

0035497

Genes

HSA:	468(ATF4)
PTR:	744513(ATF4)
PPS:	100988487(ATF4)
GGO:	101139584(ATF4)
PON:	100462459(ATF4)
MCC:	703965(ATF4)
MMU:	11911(Atf4)
RNO:	79255(Atf4)
CFA:	474503(ATF4)
AML:	100476284
FCA:	101084297(ATF4)
BTA:	509107(ATF4)
SSC:	100144302(ATF4)
ECB:	100070334
MDO:	100012224
SHR:	100913697(ATF4)
OAA:	100089902
GGA:	395693(ATF4)
MGP:	100550984
TGU:	100190733
ACS:	100565177
XLA:	398804(atf4-a) 734165(atf4-b)
XTR:	448005(atf4)
DRE:	406514(atf4b1)
TRU:	101070714
OLA:	101172388
CIN:	778545(atf4/5)
AAG:	AaeL_AAEL012671
AME:	410226(crc)
NVI:	100122826(NV12312)
TCA:	658480
API:	100161513
ISC:	IscW_ISCW019219
TAD:	TRIADDRAFT_63596
AQU:	100634724

» show all

Reference

PMID:17466566

Authors

Ameri K, Harris AL

Title

Activating transcription factor 4.

Journal

Int J Biochem Cell Biol 40:14-21 (2008)

Reference

PMID:11483993

Authors

Mayr B, Montminy M

Title

Transcriptional regulation by the phosphorylation-dependent factor CREB.

Journal

Nat Rev Mol Cell Biol 2:599-609 (2001)

All links

Ontology (3)   
   KEGG BRITE (2)   
   GO (1)   
Pathway (34)   
   KEGG PATHWAY (34)   
Gene (65)   
   KEGG GENES (36)   
   KEGG DGENES (3)   
   KEGG EGENES (26)   
Protein sequence (38)   
   UniProt (38)   
Literature (2)   
   PubMed (2)   
All databases (142)   

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