KEGG   ORTHOLOGY: K04382Help
Entry
K04382                      KO                                     

Name
PPP2C
Definition
serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
Pathway
ko03015  mRNA surveillance pathway
ko04013  MAPK signaling pathway - fly
ko04071  Sphingolipid signaling pathway
ko04111  Cell cycle - yeast
ko04113  Meiosis - yeast
ko04114  Oocyte meiosis
ko04136  Autophagy - other
ko04138  Autophagy - yeast
ko04140  Autophagy - animal
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04350  TGF-beta signaling pathway
ko04390  Hippo signaling pathway
ko04391  Hippo signaling pathway - fly
ko04530  Tight junction
ko04728  Dopaminergic synapse
ko04730  Long-term depression
ko05142  Chagas disease (American trypanosomiasis)
ko05160  Hepatitis C
ko05165  Human papillomavirus infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Translation
   03015 mRNA surveillance pathway
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
 Environmental Information Processing
  Signal transduction
   04013 MAPK signaling pathway - fly
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04350 TGF-beta signaling pathway
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04390 Hippo signaling pathway
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04391 Hippo signaling pathway -fly
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04071 Sphingolipid signaling pathway
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04151 PI3K-Akt signaling pathway
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04152 AMPK signaling pathway
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04138 Autophagy - yeast
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04136 Autophagy - other eukaryotes
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
  Cell growth and death
   04111 Cell cycle - yeast
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04113 Meiosis - yeast
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04114 Oocyte meiosis
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
  Cellular community - eukaryotes
   04530 Tight junction
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
 Organismal Systems
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
  Nervous system
   04728 Dopaminergic synapse
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04730 Long-term depression
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
 Human Diseases
  Infectious diseases
   05160 Hepatitis C
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   05165 Human papillomavirus infection
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   05142 Chagas disease (American trypanosomiasis)
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-2 (PP2A)
    Catalytic subunits
     K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Centromeric chromatin formation proteins
   Other centromeric chromatin formation proteins
    PP2A (protein phosphatase 2A)
     K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
BRITE hierarchy
Other DBs
COG: COG0639
GO: 0004722
Genes
HSA: 5515(PPP2CA) 5516(PPP2CB)
PTR: 100614247(PPP2CA) 464100(PPP2CB) 471633
PPS: 100976101(PPP2CB) 100981626(PPP2CA) 100987323
GGO: 101125226(PPP2CB) 101152519(PPP2CA)
PON: 100437405(PPP2CB) 100461606(PPP2CA)
NLE: 100585393(PPP2CB) 100596525(PPP2CA)
MCC: 695118(PPP2CB) 710326(PPP2CA)
MCF: 101864925(PPP2CA) 102137928(PPP2CB)
CSAB: 103215586(PPP2CB) 103244545(PPP2CA)
RRO: 104659809(PPP2CA) 104668221(PPP2CB)
RBB: 108518653(PPP2CB) 108529557(PPP2CA)
CJC: 100395261(PPP2CB) 100398536(PPP2CA)
SBQ: 101028752(PPP2CA) 101037428(PPP2CB)
MMU: 19052(Ppp2ca) 19053(Ppp2cb)
RNO: 103694903 24672(Ppp2ca) 24673(Ppp2cb)
CGE: 100757400(Ppp2cb) 100766084(Ppp2ca)
NGI: 103729809(Ppp2ca) 103743584(Ppp2cb)
HGL: 101707511(Ppp2ca) 101726191(Ppp2cb)
CCAN: 109689490(Ppp2ca) 109692163(Ppp2cb)
OCU: 100009252(PPP2CA) 100009300(PPP2CB)
TUP: 102479161(PPP2CA) 102487950 102500173(PPP2CB)
CFA: 403608(PPP2CA) 482873(PPP2CB)
AML: 100464293(PPP2CA) 100473021(PPP2CB)
UMR: 103659105(PPP2CB)
ORO: 101367482(PPP2CB) 101376533(PPP2CA)
FCA: 101094667(PPP2CB) 101099271(PPP2CA)
PTG: 102954008(PPP2CA) 102956715(PPP2CB)
AJU: 106966583(PPP2CB) 106984892(PPP2CA)
BTA: 282320(PPP2CA) 524361(PPP2CB)
BOM: 102266065(PPP2CA) 102279886 102282540(PPP2CB)
BIU: 109553505(PPP2CB) 109562017(PPP2CA)
PHD: 102326922(PPP2CB) 102337284(PPP2CA)
CHX: 102175016(PPP2CA) 102182013(PPP2CB) 108637886
OAS: 101114930(PPP2CB) 443009(PPP2CA)
SSC: 397136(PPP2CB) 397656(PPP2CA)
CFR: 102509650(PPP2CB) 106728419(PPP2CA)
CDK: 105090279(PPP2CA) 105095814(PPP2CB)
BACU: 103000342(PPP2CB) 103018989(PPP2CA) 103019215
LVE: 103074714(PPP2CA) 103086967(PPP2CB)
OOR: 101282700 101286814(PPP2CB) 101289109(PPP2CA)
ECB: 100062224(PPP2CB)
EPZ: 103543523(PPP2CA) 103565579(PPP2CB)
EAI: 106824437(PPP2CB) 106834655(PPP2CA)
MYB: 102246010(PPP2CA) 102255371(PPP2CB)
MYD: 102762679(PPP2CA) 102771922(PPP2CB)
HAI: 109382627(PPP2CA) 109382969(PPP2CB)
PALE: 102885289(PPP2CA) 102887013(PPP2CB)
LAV: 100664132(PPP2CA) 100676230(PPP2CB)
MDO: 100012652(PPP2CB) 100017519(PPP2CA)
SHR: 100921980(PPP2CB) 100927043(PPP2CA) 100932648
OAA: 100082155 100082697(PPP2CB)
GGA: 396021(PPP2CB) 416318(PPP2CA)
MGP: 100546612(PPP2CA) 100549769(PPP2CB)
CJO: 107313198(PPP2CB) 107320210(PPP2CA)
APLA: 101799879(PPP2CB) 101803206(PPP2CA)
ACYG: 106032768(PPP2CA) 106035222(PPP2CB)
TGU: 100190531(PPP2CB) 100218838 100228749(PPP2CA)
GFR: 102036925(PPP2CA) 102042538(PPP2CB)
FAB: 101814178(PPP2CA)
PHI: 102100299(PPP2CA) 102109205(PPP2CB)
PMAJ: 107203383(PPP2CB) 107210640(PPP2CA)
CCW: 104683725(PPP2CA) 104696831(PPP2CB)
FPG: 101919502(PPP2CA) 101920842(PPP2CB)
FCH: 102052989(PPP2CB) 102058381(PPP2CA)
CLV: 102085353 102093920(PPP2CA)
EGZ: 104133477(PPP2CA) 104135437(PPP2CB)
AAM: 106487221(PPP2CA) 106494814
ASN: 102386870(PPP2CB) 102387234(PPP2CA)
AMJ: 102576713(PPP2CB) 102576911(PPP2CA)
PSS: 102446185(PPP2CA) 102457538(PPP2CB)
CMY: 102942368 102945505(PPP2CB)
CPIC: 101939877(PPP2CA) 101952365(PPP2CB)
ACS: 100558622(ppp2cb) 100568233(ppp2ca)
PVT: 110079404(PPP2CA) 110087364(PPP2CB)
PBI: 103051395(PPP2CA) 103064597
GJA: 107110575 107125982(PPP2CA)
XLA: 108706827 108712618 380045(ppp2ca.L) 399343(ppp2cb.L)
XTR: 394888(ppp2ca) 448031(ppp2cb)
NPR: 108792131 108798842(PPP2CB)
DRE: 393885(zgc:56064) 406582(ppp2cb) 550585(ppp2ca)
IPU: 100528132(ppp2cb) 108274658(ppp2ca)
AMEX: 103033752(ppp2cb) 103045214(ppp2ca)
TRU: 101065017(ppp2cb) 101068850(ppp2ca)
LCO: 104924365(ppp2ca) 104935225(ppp2cb) 104938463
MZE: 101470047(ppp2ca) 101479611(ppp2cb) 101487597
OLA: 101157601(ppp2cb) 101173325(ppp2ca)
XMA: 102221749(ppp2ca) 102223777 102237558(ppp2cb)
PRET: 103459981(ppp2ca) 103470779(ppp2cb) 103471193
NFU: 107373442 107386136(ppp2cb) 107386839(ppp2ca)
CSEM: 103391208 103394862(ppp2ca) 103398006(ppp2cb) 103399619
LCM: 102349792(PPP2CA) 102350821
CMK: 103183681(ppp2ca) 103186729
CIN: 100186064
SPU: 580852
APLC: 110977570
SKO: 100374420
DME: Dmel_CG7109(mts)
DSI: Dsimw501_GD23492(Dsim_GD23492)
MDE: 101900976
AAG: 5580325
AME: 550710(mts)
BIM: 100741688
BTER: 100646859
SOC: 105201502
AEC: 105143155
ACEP: 105627845
PBAR: 105425620
HST: 105189916
CFO: 105257262
LHU: 105668142
PGC: 109863721
NVI: 100118571
TCA: 662352
DPA: 109536915
NVL: 108568419
BMOR: 101737820
PMAC: 106710258
PRAP: 110995428
API: 100144917
DNX: 107167247
ZNE: 110831023
FCD: 110842354
TUT: 107362015
CEL: CELE_F38H4.9(let-92)
CBR: CBG06179(Cbr-let-92)
TSP: Tsp_04401
CRG: 105341231
MYI: 110457665
LAK: 106170761
SHX: MS3_05437
ADF: 107352888
HMG: 100201603
AQU: 100641577
ATH: AT1G10430(PP2A-2) AT1G59830(PP2A-1) AT1G69960(PP2A) AT2G42500(PP2A-3) AT3G58500(PP2A-4)
LJA: Lj0g3v0138929.1(Lj0g3v0138929.1) Lj1g3v4763900.1(Lj1g3v4763900.1) Lj2g3v1364780.1(Lj2g3v1364780.1) Lj4g3v2603900.1(Lj4g3v2603900.1)
SLY: 101245881 101252803 101257003 544183(PP2Ac1) 544262(PP2Ac2)
DOSA: Os02t0217600-01(Os02g0217600) Os03t0167700-01(Os03g0167700) Os03t0805300-01(Os03g0805300) Os06t0574500-01(Os06g0574500)
ATS: 109733394(LOC109733394) 109770537(LOC109770537) 109771013(LOC109771013) 109771400(LOC109771400) 109775911(LOC109775911)
APRO: F751_0347
SCE: YDL134C(PPH21) YDL188C(PPH22)
ERC: Ecym_8052
KMX: KLMA_60499(PPH21)
NCS: NCAS_0A13850(NCAS0A13850) NCAS_0E03680(NCAS0E03680)
NDI: NDAI_0A02190(NDAI0A02190) NDAI_0A02950(NDAI0A02950)
TPF: TPHA_0A03180(TPHA0A03180) TPHA_0P00880(TPHA0P00880)
TBL: TBLA_0A05910(TBLA0A05910) TBLA_0F02060(TBLA0F02060)
TDL: TDEL_0C02450(TDEL0C02450)
KAF: KAFR_0B01120(KAFR0B01120)
CAL: CAALFM_C301600WA(PPH21)
SLB: AWJ20_1003(PPH21) AWJ20_4729(PPH21)
NCR: NCU06630(pph-1)
NTE: NEUTE1DRAFT59886(NEUTE1DRAFT_59886)
MGR: MGG_06099
MAW: MAC_06412
MAJ: MAA_05062
CMT: CCM_04272
MBE: MBM_01984
ANI: AN6391.2
ANG: ANI_1_1608104(An12g02970) ANI_1_58094(An11g00420)
ABE: ARB_02777
TVE: TRV_03388
PTE: PTT_16076
ZTR: MYCGRDRAFT_101229(MgPP2Ac)
SPO: SPAC823.15(ppa1) SPBC16H5.07c(ppa2)
CNE: CNE03610
CNB: CNBE3610
PPL: POSPLDRAFT_122071(PP2A-2) POSPLDRAFT_90738(PP2A-3)
ABP: AGABI1DRAFT114427(AGABI1DRAFT_114427)
ABV: AGABI2DRAFT191462(AGABI2DRAFT_191462)
MGL: MGL_0499
DDI: DDB_G0290263(pho2A)
DFA: DFA_06423
EHI: EHI_011950(16.t00005)
PYO: PY17X_0829500(PY00926)
PCB: PCHAS_082650(PC000855.01.0)
TAN: TA15515
TPV: TP02_0853
BBO: BBOV_I000740(16.m00696)
SMIN: v1.2.018382.t1(symbB.v1.2.018382.t1) v1.2.019959.t1(symbB.v1.2.019959.t1) v1.2.019959.t2(symbB.v1.2.019959.t2) v1.2.033440.t1(symbB.v1.2.033440.t1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2849764
  Authors
Stone SR, Mayer R, Wernet W, Maurer F, Hofsteenge J, Hemmings BA
  Title
The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A alpha catalytic subunit.
  Journal
Nucleic Acids Res 16:11365 (1988)
DOI:10.1093/nar/16.23.11365
  Sequence
[hsa:5515]
Reference
PMID:2849765
  Authors
Hemmings BA, Wernet W, Mayer R, Maurer F, Hofsteenge J, Stone SR
  Title
The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A beta catalytic subunit.
  Journal
Nucleic Acids Res 16:11366 (1988)
DOI:10.1093/nar/16.23.11366
  Sequence
[hsa:5516]

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