KEGG   ORTHOLOGY: K04392Help
Entry
K04392                      KO                                     

Name
RAC1
Definition
Ras-related C3 botulinum toxin substrate 1
Pathway
ko04010  MAPK signaling pathway
ko04013  MAPK signaling pathway - fly
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04071  Sphingolipid signaling pathway
ko04145  Phagosome
ko04151  PI3K-Akt signaling pathway
ko04310  Wnt signaling pathway
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04380  Osteoclast differentiation
ko04510  Focal adhesion
ko04520  Adherens junction
ko04530  Tight junction
ko04620  Toll-like receptor signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04670  Leukocyte transendothelial migration
ko04722  Neurotrophin signaling pathway
ko04810  Regulation of actin cytoskeleton
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04972  Pancreatic secretion
ko05014  Amyotrophic lateral sclerosis (ALS)
ko05100  Bacterial invasion of epithelial cells
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05131  Shigellosis
ko05132  Salmonella infection
ko05167  Kaposi's sarcoma-associated herpesvirus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05205  Proteoglycans in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05231  Choline metabolism in cancer
ko05416  Viral myocarditis
ko05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04015 Rap1 signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04010 MAPK signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04013 MAPK signaling pathway - fly
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04310 Wnt signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04370 VEGF signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04071 Sphingolipid signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04024 cAMP signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04151 PI3K-Akt signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04520 Adherens junction
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04530 Tight junction
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04650 Natural killer cell mediated cytotoxicity
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04662 B cell receptor signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04664 Fc epsilon RI signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04666 Fc gamma R-mediated phagocytosis
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04670 Leukocyte transendothelial migration
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04062 Chemokine signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Digestive system
   04972 Pancreatic secretion
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Nervous system
   04722 Neurotrophin signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Development
   04360 Axon guidance
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04380 Osteoclast differentiation
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05231 Choline metabolism in cancer
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05205 Proteoglycans in cancer
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05203 Viral carcinogenesis
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05210 Colorectal cancer
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05212 Pancreatic cancer
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05211 Renal cell carcinoma
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05416 Viral myocarditis
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05132 Salmonella infection
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05131 Shigellosis
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05100 Bacterial invasion of epithelial cells
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
Membrane trafficking [BR:ko04131]
 Exocytosis
  Small GTPases and associated proteins
   Rho GTPases
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
 Endocytosis
  Lipid raft mediated endocytosis
   Arf6-dependent endocytosis
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Phagocytosis
   NADPH oxidase complex
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Macropinocytosis
   Ras GTPases
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
 Others
  NADPH oxidases (Nox) and associated proteins
   Nox associated proteins
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Exosomal proteins of other body fluids (saliva and urine)
   K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Exosomal proteins of colorectal cancer cells
   K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Exosomal proteins of bladder cancer cells
   K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
GTP-binding proteins [BR:ko04031]
 Small (Monomeric) G-proteins
  Rho Family
   Rac/Cdc42 [OT]
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
BRITE hierarchy
Genes
HSA: 5879(RAC1)
PTR: 741907(RAC1)
PPS: 100976112(RAC1) 100985182 100989777
GGO: 101126671 101135430(RAC1)
PON: 100443271(RAC1)
NLE: 100604516(RAC1) 105738104
MCC: 717755(RAC1)
MCF: 101866593(RAC1)
CSAB: 103246815(RAC1)
RRO: 104665823(RAC1)
RBB: 108515883 108523982(RAC1)
CJC: 100404109(RAC1)
SBQ: 101042808(RAC1)
MMU: 19353(Rac1)
RNO: 363875(Rac1)
CGE: 100756792(Rac1)
NGI: 103726484(Rac1)
HGL: 101706434(Rac1)
CCAN: 109692922(Rac1)
OCU: 100339873(RAC1)
TUP: 102479102(RAC1)
CFA: 403955(RAC1)
AML: 100465648(RAC1)
UMR: 103670095(RAC1)
ORO: 101366544 101378519(RAC1)
FCA: 101101277(RAC1)
PTG: 102968561(RAC1)
AJU: 106982604(RAC1)
BTA: 281440(RAC1)
BOM: 102273253(RAC1)
BIU: 109578192(RAC1)
PHD: 102315377(RAC1)
CHX: 102173438(RAC1)
OAS: 100101233(RAC1)
SSC: 100627149(RAC1)
CFR: 102516893(RAC1)
CDK: 105099381(RAC1)
BACU: 103007995(RAC1)
LVE: 103074749(RAC1)
OOR: 101274018(RAC1)
ECB: 100061732(RAC1)
EPZ: 103552260 103555780(RAC1)
EAI: 106840518(RAC1)
MYB: 102259160(RAC1)
MYD: 102759477(RAC1)
HAI: 109380150(RAC1)
PALE: 102897644(RAC1)
LAV: 100664204(RAC1)
TMU: 101356054
MDO: 100026992(RAC1)
SHR: 100919657(RAC1)
OAA: 100076220(RAC1)
GGA: 395871(RAC1)
MGP: 100548156(RAC1)
CJO: 107320829(RAC1)
APLA: 101801980(RAC1)
ACYG: 106033506(RAC1)
TGU: 100221287(RAC1)
GFR: 102035279(RAC1)
FAB: 101821415(RAC1)
PHI: 102111634(RAC1)
PMAJ: 107211176(RAC1)
CCW: 104684856(RAC1)
FPG: 101921306(RAC1)
FCH: 102049998(RAC1)
CLV: 102091892(RAC1)
EGZ: 104135819(RAC1)
AAM: 106491345(RAC1)
ASN: 102384525(RAC1)
AMJ: 102576455(RAC1)
PSS: 102455188(RAC1)
CMY: 102945867(RAC1)
CPIC: 101942767(RAC1)
ACS: 100561917(rac1)
PVT: 110082204(RAC1)
PBI: 103055010(RAC1)
GJA: 107123053(RAC1)
XLA: 399379(rac3.S) 734382(rac1.L)
XTR: 448118(rac1)
NPR: 108794473(RAC1)
DRE: 327204(rac1a) 562838(rac1b) 792699(rac1l)
IPU: 108257150(Rac1) 108273830
TRU: 101063410(rac1) 101067160
LCO: 104918062(rac1) 104918805
LCF: 108880774(rac1)
HCQ: 109516523(rac1)
BPEC: 110159668(rac1)
ELS: 105026138 105031492(rac1)
SFM: 108933523 108940105(rac1)
LCM: 102352006 102367135(RAC1)
CIN: 108949744 445702 448954(rac2) 448955(rac3a) 448957 448958 619233(rcl2) 619234(rcl1)
DME: Dmel_CG2248(Rac1) Dmel_CG5588(Mtl) Dmel_CG8556(Rac2) Dmel_CG9366(RhoL)
DSI: Dsimw501_GD13056(Dsim_GD13056) Dsimw501_GD13487(Dsim_GD13487) Dsimw501_GD20793(Dsim_GD20793) Dsimw501_GD21343(Dsim_GD21343)
AME: 551554(Rac) 552138(GB17936) 552419
TCA: 656493 656798(Rac1) 660912(RhoL)
CEL: CELE_C09G12.8(ced-10) CELE_C35C5.4(mig-2) CELE_K03D3.10(rac-2)
CBR: CBG15031 CBG17302(Cbr-mig-2)
BMY: Bm1_00680
HMG: 100206675
ATH: AT1G20090(ROP2) AT1G75840(ARAC5) AT2G17800(ARAC1) AT2G44690(ARAC9) AT3G48040(ROP10) AT3G51300(ROP1) AT4G28950(ROP9) AT4G35020(RAC3) AT4G35950(RAC6) AT5G45970(RAC2) AT5G62880(RAC10)
LJA: Lj0g3v0167719.1(Lj0g3v0167719.1) Lj1g3v0415230.1(Lj1g3v0415230.1) Lj1g3v2185260.1(Lj1g3v2185260.1) Lj1g3v2185270.1(Lj1g3v2185270.1) Lj1g3v2185270.2(Lj1g3v2185270.2) Lj1g3v2185270.3(Lj1g3v2185270.3) Lj1g3v2185280.1(Lj1g3v2185280.1) Lj1g3v3331690.3(Lj1g3v3331690.3) Lj2g3v0813080.1(Lj2g3v0813080.1) Lj2g3v1670990.1(Lj2g3v1670990.1) Lj2g3v1670990.2(Lj2g3v1670990.2) Lj3g3v2838500.1(Lj3g3v2838500.1) Lj3g3v3453430.1(Lj3g3v3453430.1)
POP: 7485604
DOSA: Os01t0229400-01(Os01g0229400) Os01t0540300-00(Os01g0540300) Os02t0120800-01(Os02g0120800) Os02t0312600-01(Os02g0312600) Os02t0742200-01(Os02g0742200) Os02t0834000-01(Os02g0834000) Os05t0513800-01(Os05g0513800) Os06t0234200-01(Os06g0234200)
ATS: 109746266(LOC109746266) 109748476(LOC109748476) 109754831(LOC109754831) 109761271(LOC109761271) 109770849(LOC109770849) 109777807(LOC109777807)
ZMA: 541773(rop1) 541774(rop3) 541930(GTPase) 542017(rop6) 542094(rop9) 542503(rop7) 542618(rop2) 542739(rop4) 542758(rop5)
CAL: CAALFM_C106730WA(RAC1)
CAUR: QG37_04785
SLB: AWJ20_2632(CDC42)
NCR: NCU02160(rac-1)
NTE: NEUTE1DRAFT118459(NEUTE1DRAFT_118459)
SMP: SMAC_09071(rac)
MGR: MGG_02731
TRE: TRIREDRAFT_47055(rac1)
MAW: MAC_07582
MAJ: MAA_03762
MBE: MBM_06296
ANI: AN4743.2
ANG: ANI_1_1302094(An11g10030)
ABE: ARB_07304
TVE: TRV_02036
PTE: PTT_09931
MRR: Moror_46
MGL: MGL_1797
DFA: DFA_01172(racL) DFA_01265(racH) DFA_03542 DFA_05667(racD) DFA_07280(racE) DFA_09904(racP) DFA_10342 DFA_10379(racB) DFA_10726(rac1A) DFA_10836(racC)
EHI: EHI_140190(8.t00018) EHI_181250(97.t00016) EHI_197840(197.t00011)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Shibata S, Nagase M, Yoshida S, Kawarazaki W, Kurihara H, Tanaka H, Miyoshi J, Takai Y, Fujita T
  Title
Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease.
  Journal
Nat Med 14:1370-6 (2008)
DOI:10.1038/nm.1879
Reference
  Authors
Jordan P, Brazao R, Boavida MG, Gespach C, Chastre E
  Title
Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors.
  Journal
Oncogene 18:6835-9 (1999)
DOI:10.1038/sj.onc.1203233
  Sequence
[hsa:5879]

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