KEGG   ORTHOLOGY: K04392Help
Entry
K04392                      KO                                     

Name
RAC1
Definition
Ras-related C3 botulinum toxin substrate 1
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Chemokine signaling pathway
Phagosome
PI3K-Akt signaling pathway
Wnt signaling pathway
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Adherens junction
Toll-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Regulation of actin cytoskeleton
Non-alcoholic fatty liver disease (NAFLD)
Pancreatic secretion
Amyotrophic lateral sclerosis (ALS)
Bacterial invasion of epithelial cells
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Salmonella infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Viral myocarditis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04015 Rap1 signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04010 MAPK signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04310 Wnt signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04370 VEGF signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04151 PI3K-Akt signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Cell communication
   04510 Focal adhesion
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04520 Adherens junction
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04650 Natural killer cell mediated cytotoxicity
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04662 B cell receptor signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04664 Fc epsilon RI signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04666 Fc gamma R-mediated phagocytosis
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04670 Leukocyte transendothelial migration
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04062 Chemokine signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Digestive system
   04972 Pancreatic secretion
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Nervous system
   04722 Neurotrophin signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Development
   04360 Axon guidance
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04380 Osteoclast differentiation
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05205 Proteoglycans in cancer
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05203 Viral carcinogenesis
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05210 Colorectal cancer
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05212 Pancreatic cancer
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05211 Renal cell carcinoma
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Cardiovascular diseases
   05416 Viral myocarditis
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05132 Salmonella infection
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05131 Shigellosis
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05100 Bacterial invasion of epithelial cells
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Exosomal proteins of other body fluids (saliva and urine)
   K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Exosomal proteins of colorectal cancer cells
   K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Exosomal proteins of bladder cancer cells
   K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
GTP-binding proteins [BR:ko04031]
 Small (Monomeric) G-proteins
  Rho Family
   Rac/Cdc42 [Table]
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
BRITE hierarchy
Genes
HSA: 
5879(RAC1)
PTR: 
741907(RAC1)
PPS: 
GGO: 
101135430(RAC1)
PON: 
MCC: 
MCF: 
MMU: 
19353(Rac1)
RNO: 
363875(Rac1)
CGE: 
TUP: 
102479102(RAC1)
CFA: 
403955(RAC1)
FCA: 
101101277(RAC1)
BTA: 
281440(RAC1)
BOM: 
102273253(RAC1)
PHD: 
102315377(RAC1)
CHX: 
102173438(RAC1)
SSC: 
100627149(RAC1)
CFR: 
102516893(RAC1)
ECB: 
MYB: 
102259160(RAC1)
MDO: 
SHR: 
100919657(RAC1)
OAA: 
GGA: 
395871(RAC1)
MGP: 
TGU: 
100221287(RAC1)
FAB: 
101821415(RAC1)
PHI: 
102111634(RAC1)
APLA: 
101801980(RAC1)
FCH: 
102049998(RAC1)
CLV: 
102091892(RAC1)
ASN: 
102384525(RAC1)
PSS: 
102455188(RAC1)
ACS: 
XLA: 
399379(rac3) 734382(rac1)
XTR: 
448118(rac1)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102367135(RAC1)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
551554(Rac) 552138(GB17936)
NVI: 
100115463(RAC1)
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG15031 CBG17302(Cbr-mig-2)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT1G20090(ROP2) AT1G75840(ARAC5) AT2G17800(ARAC1) AT2G44690(ARAC9) AT3G48040(ROP10) AT3G51300(ROP1) AT4G28950(ROP9) AT4G35020(RAC3) AT4G35950(RAC6) AT5G45970(RAC2) AT5G62880(RAC10)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os02t0120800-01(Os02g0120800) Os02t0312600-01(Os02g0312600) Os02t0742200-01(Os02g0742200) Os02t0834000-01(Os02g0834000) Os05t0513800-01(Os05g0513800)
BDI: 
SBI: 
SORBI_04g001690(SORBIDRAFT_04g001690) SORBI_04g028280(SORBIDRAFT_04g028280) SORBI_09g007420(SORBIDRAFT_09g007420) SORBI_09g025400(SORBIDRAFT_09g025400) SORBI_10g008380(SORBIDRAFT_10g008380)
ZMA: 
100381374 541773(rop1) 541774(rop3) 542017(rop6) 542094(rop9) 542739(rop4) 542758(rop5)
SITA: 
SMO: 
PPP: 
OLU: 
OTA: 
MIS: 
MPP: 
CME: 
GSL: 
YLI: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
VAL: 
SSL: 
ANI: 
NFI: 
AFM: 
AOR: 
AOR_1_224084(AO090020000127)
ANG: 
ANI_1_1302094(An11g10030)
AFV: 
ACT: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
AJE: 
PNO: 
PTE: 
ZTR: 
TML: 
CNE: 
CNB: 
CGI: 
PPL: 
LBC: 
CCI: 
SCM: 
UMA: 
MGL: 
PGR: 
MBR: 
DDI: 
DPP: 
DFA: 
DFA_05667(racD) DFA_10726(rac1A)
EHI: 
EHI_140190(8.t00018) EHI_181250(97.t00016) EHI_197840(197.t00011)
EDI: 
TET: 
PTM: 
PIF: 
EHX: 
GTT: 
NGR: 
TVA: 
GLA: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
Reference
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
Reference
  Authors
Wennerberg K, Der CJ.
  Title
Rho-family GTPases: it's not only Rac and Rho (and I like it).
  Journal
J Cell Sci 117:1301-12 (2004)

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