KEGG   ORTHOLOGY: K04398Help
Entry
K04398                      KO                                     

Name
CASP8
Definition
caspase 8 [EC:3.4.22.61]
Pathway
p53 signaling pathway
Apoptosis
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
TNF signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer's disease
Huntington's disease
Legionellosis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis B
Herpes simplex infection
Pathways in cancer
Viral carcinogenesis
Viral myocarditis
Disease
H00108  
Autoimmune lymphoproliferative syndromes (ALPS)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04668 TNF signaling pathway
    K04398  CASP8; caspase 8
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K04398  CASP8; caspase 8
   04115 p53 signaling pathway
    K04398  CASP8; caspase 8
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04398  CASP8; caspase 8
   04621 NOD-like receptor signaling pathway
    K04398  CASP8; caspase 8
   04622 RIG-I-like receptor signaling pathway
    K04398  CASP8; caspase 8
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04398  CASP8; caspase 8
   05203 Viral carcinogenesis
    K04398  CASP8; caspase 8
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K04398  CASP8; caspase 8
   05016 Huntington's disease
    K04398  CASP8; caspase 8
  Cardiovascular diseases
   05416 Viral myocarditis
    K04398  CASP8; caspase 8
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04398  CASP8; caspase 8
  Infectious diseases
   05134 Legionellosis
    K04398  CASP8; caspase 8
   05152 Tuberculosis
    K04398  CASP8; caspase 8
   05161 Hepatitis B
    K04398  CASP8; caspase 8
   05168 Herpes simplex infection
    K04398  CASP8; caspase 8
   05145 Toxoplasmosis
    K04398  CASP8; caspase 8
   05142 Chagas disease (American trypanosomiasis)
    K04398  CASP8; caspase 8
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.61  caspase-8
     K04398  CASP8; caspase 8
Peptidases [BR:ko01002]
 Cysteine Peptidases
  Family C14: caspase family
   K04398  CASP8; caspase 8
BRITE hierarchy
Genes
HSA: 
841(CASP8)
PTR: 
746477(CASP8)
PPS: 
100978497(CASP8)
GGO: 
PON: 
100172115(CASP8)
NLE: 
100586183(CASP8)
MCC: 
702781(CASP8)
MCF: 
CJC: 
100395220(CASP8)
MMU: 
12370(Casp8)
RNO: 
64044(Casp8)
CGE: 
100689369(Casp8)
NGI: 
HGL: 
101702773(Casp8)
OCU: 
100348477(CASP8)
TUP: 
102498355(CASP8)
CFA: 
488473(CASP8)
AML: 
100472842(CASP8)
UMR: 
103659742(CASP8)
FCA: 
100142684(CASP8)
PTG: 
102962460(CASP8)
BTA: 
507481(CASP8)
BOM: 
102272602(CASP8)
PHD: 
102326267(CASP8)
CHX: 
102169919(CASP8)
OAS: 
101107334(CASP8)
SSC: 
595105(CASP8)
CFR: 
102508224(CASP8)
BACU: 
103004642(CASP8)
LVE: 
103077054(CASP8)
ECB: 
100066502(CASP8)
MYB: 
102246377(CASP8)
MYD: 
102761550(CASP8)
PALE: 
102878181(CASP8)
MDO: 
100017025(CASP18) 100617599(CASP8)
SHR: 
OAA: 
GGA: 
395284(CASP8)
MGP: 
TGU: 
FAB: 
PHI: 
FPG: 
101916968(CASP8)
FCH: 
102056597(CASP8)
CLV: 
ASN: 
AMJ: 
PSS: 
102446244(CASP8)
CMY: 
XLA: 
373559(casp8)
XTR: 
100495471(casp8)
DRE: 
557302(casp8l2) 58022(casp8)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103171902(casp8)
BFO: 
CIN: 
SPU: 
LGI: 
NVE: 
HMG: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9931493
  Authors
Grenet J, Teitz T, Wei T, Valentine V, Kidd VJ
  Title
Structure and chromosome localization of the human CASP8 gene.
  Journal
Gene 226:225-32 (1999)
Reference
  Authors
Sakamaki K, Satou Y
  Title
Caspases: evolutionary aspects of their functions in vertebrates.
  Journal
J Fish Biol 74:727-53 (2009)
Reference
  Authors
Chowdhury I, Tharakan B, Bhat GK
  Title
Caspases - an update.
  Journal
Comp Biochem Physiol B Biochem Mol Biol 151:10-27 (2008)

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