KEGG   ORTHOLOGY: K04398Help
Entry
K04398                      KO                                     
Name
CASP8
Definition
caspase 8 [EC:3.4.22.61]
Pathway
p53 signaling pathway
Apoptosis
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Alzheimer's disease
Huntington's disease
Legionellosis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis B
Herpes simplex infection
Pathways in cancer
Viral carcinogenesis
Viral myocarditis
Disease
H00108  
Autoimmune lymphoproliferative syndromes (ALPS)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K04398  CASP8; caspase 8
   04115 p53 signaling pathway
    K04398  CASP8; caspase 8
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04398  CASP8; caspase 8
   04621 NOD-like receptor signaling pathway
    K04398  CASP8; caspase 8
   04622 RIG-I-like receptor signaling pathway
    K04398  CASP8; caspase 8
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04398  CASP8; caspase 8
   05203 Viral carcinogenesis
    K04398  CASP8; caspase 8
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K04398  CASP8; caspase 8
   05016 Huntington's disease
    K04398  CASP8; caspase 8
  Cardiovascular diseases
   05416 Viral myocarditis
    K04398  CASP8; caspase 8
  Infectious diseases
   05134 Legionellosis
    K04398  CASP8; caspase 8
   05152 Tuberculosis
    K04398  CASP8; caspase 8
   05161 Hepatitis B
    K04398  CASP8; caspase 8
   05168 Herpes simplex infection
    K04398  CASP8; caspase 8
   05145 Toxoplasmosis
    K04398  CASP8; caspase 8
   05142 Chagas disease (American trypanosomiasis)
    K04398  CASP8; caspase 8
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.61  caspase-8
     K04398  CASP8; caspase 8
Peptidases [BR:ko01002]
 Cysteine Peptidases
  Family C14: caspase family
   K04398  CASP8; caspase 8
BRITE hierarchy
Genes
HSA: 
841(CASP8)
PTR: 
746477(CASP8)
PPS: 
100978497(CASP8)
GGO: 
101138898(CASP8)
PON: 
100172115(CASP8)
MCC: 
702781(CASP8)
MMU: 
12370(Casp8)
RNO: 
64044(Casp8)
CFA: 
488473(CASP8)
AML: 
100472842(CASP8)
FCA: 
100142684(CASP8)
BTA: 
507481(CASP8)
SSC: 
595105(CASP8)
ECB: 
100066502(CASP8)
MDO: 
100017025(CASP18) 100617599
SHR: 
100931580
OAA: 
100082949 100087835
GGA: 
395284(CASP8)
MGP: 
100541513 100541666
TGU: 
100222284
XLA: 
373559(casp8)
XTR: 
100495471
DRE: 
557302(casp8l2) 58022(casp8)
TRU: 
101075631
OLA: 
100049400(casp8)
BFO: 
BRAFLDRAFT_194931
SPU: 
585496
HMG: 
100207763
AQU: 
100638885
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9931493
  Authors
Grenet J, Teitz T, Wei T, Valentine V, Kidd VJ
  Title
Structure and chromosome localization of the human CASP8 gene.
  Journal
Gene 226:225-32 (1999)
Reference
  Authors
Sakamaki K, Satou Y
  Title
Caspases: evolutionary aspects of their functions in vertebrates.
  Journal
J Fish Biol 74:727-53 (2009)
Reference
  Authors
Chowdhury I, Tharakan B, Bhat GK
  Title
Caspases - an update.
  Journal
Comp Biochem Physiol B Biochem Mol Biol 151:10-27 (2008)
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