KEGG   ORTHOLOGY: K04416Help
Entry
K04416                      KO                                     

Name
MAP3K1, MEKK1
Definition
mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
Pathway
MAPK signaling pathway
Ubiquitin mediated proteolysis
RIG-I-like receptor signaling pathway
Neurotrophin signaling pathway
GnRH signaling pathway
Hepatitis B
HTLV-I infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
 Organismal Systems
  Immune system
   04622 RIG-I-like receptor signaling pathway
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
  Endocrine system
   04912 GnRH signaling pathway
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
  Nervous system
   04722 Neurotrophin signaling pathway
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
 Human Diseases
  Infectious diseases
   05166 HTLV-I infection
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
   05161 Hepatitis B
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: STE group
  STE11 family
   K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  single Ring-finger type E3
   Other single Ring-finger type E3
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
4214(MAP3K1)
PTR: 
471543(MAP3K1)
PPS: 
100994796(MAP3K1)
GGO: 
101136722(MAP3K1)
PON: 
100453309(MAP3K1)
MCC: 
710979(MAP3K1)
MCF: 
102123041(MAP3K1)
MMU: 
26401(Map3k1)
RNO: 
116667(Map3k1)
CGE: 
100770540(Map3k1)
HGL: 
101720769(Map3k1)
TUP: 
102483890(MAP3K1)
CFA: 
478061(MAP3K1)
AML: 
100466442(MAP3K1)
FCA: 
101090328(MAP3K1)
PTG: 
102971191(MAP3K1)
BTA: 
523962(MAP3K1)
BOM: 
102267592(MAP3K1)
PHD: 
102329106(MAP3K1)
CHX: 
102187530(MAP3K1)
OAS: 
101112260(MAP3K1)
SSC: 
396617(MAP3K1)
CFR: 
102505358(MAP3K1)
BACU: 
103002185(MAP3K1)
LVE: 
103083385(MAP3K1)
ECB: 
100061688(MAP3K1)
MYB: 
102258632(MAP3K1)
MYD: 
102763786(MAP3K1)
PALE: 
102886741(MAP3K1)
MDO: 
100032065(MAP3K1)
SHR: 
100913571(MAP3K1)
OAA: 
100076612(MAP3K1)
GGA: 
427144(MAP3K1)
MGP: 
100550623(MAP3K1)
TGU: 
100225825(MAP3K1)
FAB: 
101807669(MAP3K1)
PHI: 
102103765(MAP3K1)
APLA: 
FPG: 
101911178(MAP3K1)
FCH: 
102045898(MAP3K1)
CLV: 
102097744(MAP3K1)
ASN: 
102376941(MAP3K1)
AMJ: 
102562794(MAP3K1)
PSS: 
102463619(MAP3K1)
CMY: 
102938448(MAP3K1)
ACS: 
100561745(map3k1)
PBI: 
103048285(MAP3K1)
XTR: 
100490504(map3k1)
DRE: 
100334486(map3k1)
LCM: 
102355070(MAP3K1)
CMK: 
103177870(map3k1)
BFO: 
SPU: 
ISC: 
SMM: 
NVE: 
HMG: 
TAD: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Craig EA, Stevens MV, Vaillancourt RR, Camenisch TD
  Title
MAP3Ks as central regulators of cell fate during development.
  Journal
Dev Dyn 237:3102-14 (2008)
Reference
  Authors
Lu Z, Xu S, Joazeiro C, Cobb MH, Hunter T
  Title
The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2.
  Journal
Mol Cell 9:945-56 (2002)
Reference
  Authors
Morrison DK, Davis RJ
  Title
Regulation of MAP kinase signaling modules by scaffold proteins in mammals.
  Journal
Annu Rev Cell Dev Biol 19:91-118 (2003)

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