KEGG   ORTHOLOGY: K04426Help
Entry
K04426                      KO                                     

Name
MAP3K5, ASK1
Definition
mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
Pathway
Platinum drug resistance
MAPK signaling pathway
MAPK signaling pathway - fly
Sphingolipid signaling pathway
Protein processing in endoplasmic reticulum
Apoptosis
Apoptosis - fly
Tight junction
TNF signaling pathway
Neurotrophin signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Amyotrophic lateral sclerosis (ALS)
Fluid shear stress and atherosclerosis
Module
M00688  
MAPK (JNK) signaling
M00689  
MAPK (p38) signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04013 MAPK signaling pathway - fly
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04668 TNF signaling pathway
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04071 Sphingolipid signaling pathway
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04214 Apoptosis - fly
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  Cellular community - eukaryotes
   04530 Tight junction
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
 Organismal Systems
  Nervous system
   04722 Neurotrophin signaling pathway
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
 Human Diseases
  Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  Drug resistance
   01524 Platinum drug resistance
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00688  MAPK (JNK) signaling
     K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
    M00689  MAPK (p38) signaling
     K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: STE group
  STE11 family
   K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
4217(MAP3K5)
PTR: 
463023(MAP3K5)
PPS: 
100991014(MAP3K5)
GGO: 
101147354(MAP3K5)
PON: 
100458776(MAP3K5)
NLE: 
100587332(MAP3K5)
MCC: 
711382(MAP3K5)
MCF: 
101925657(MAP3K5)
CSAB: 
103240310(MAP3K5)
RRO: 
104675014(MAP3K5)
RBB: 
108522968(MAP3K5)
CJC: 
100406322(MAP3K5)
SBQ: 
101034123(MAP3K5)
MMU: 
26408(Map3k5)
RNO: 
365057(Map3k5)
CGE: 
100752376(Map3k5)
NGI: 
103724902(Map3k5)
HGL: 
101712051(Map3k5)
CCAN: 
109697041(Map3k5)
OCU: 
100340498(MAP3K5)
TUP: 
102495244(MAP3K5)
CFA: 
476215(MAP3K5)
AML: 
100475304(MAP3K5)
UMR: 
103663496(MAP3K5)
FCA: 
101082912(MAP3K5)
PTG: 
102960317(MAP3K5)
AJU: 
106983673(MAP3K5)
BTA: 
537380(MAP3K5)
BOM: 
102276849(MAP3K5)
BIU: 
109563980(MAP3K5)
PHD: 
102319571(MAP3K5)
CHX: 
102172156(MAP3K5)
OAS: 
101121018(MAP3K5)
SSC: 
100622769(MAP3K5)
CFR: 
102522243(MAP3K5)
CDK: 
105092037(MAP3K5)
BACU: 
102999328(MAP3K5)
ECB: 
100073186(MAP3K5)
EPZ: 
103556363(MAP3K5)
EAI: 
106837192(MAP3K5)
MYB: 
102256847(MAP3K5)
MYD: 
102771311(MAP3K5)
HAI: 
109385622(MAP3K5)
RSS: 
109447951(MAP3K5)
PALE: 
102888994(MAP3K5)
LAV: 
100658813(MAP3K5)
MDO: 
100031527(MAP3K5)
SHR: 
100917439(MAP3K5)
OAA: 
100081079(MAP3K5)
GGA: 
421688(MAP3K5)
MGP: 
100551250(MAP3K5)
CJO: 
107311662(MAP3K5)
APLA: 
101799109(MAP3K5)
ACYG: 
106032515(MAP3K5)
TGU: 
100224192(MAP3K5)
GFR: 
102034507(MAP3K5)
FAB: 
101813811(MAP3K5)
PHI: 
102104081(MAP3K5)
PMAJ: 
107201551(MAP3K5)
CCW: 
104689448(MAP3K5)
FPG: 
101911552(MAP3K5)
FCH: 
102057038(MAP3K5)
CLV: 
102085051(MAP3K5)
AAM: 
106497979(MAP3K5)
ASN: 
102375722(MAP3K5)
AMJ: 
102573024(MAP3K5)
PSS: 
102451227(MAP3K5)
CMY: 
102936034(MAP3K5)
CPIC: 
101943963(MAP3K5)
ACS: 
100551616(map3k5)
PVT: 
110071741(MAP3K5)
PBI: 
103052010(MAP3K5)
GJA: 
XLA: 
XTR: 
100497692(map3k5)
NPR: 
108787404(MAP3K5)
DRE: 
100005496(si:ch211-1i11.3) 555703(map3k5)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102346861(MAP3K5) 102352283(MAP3K6)
CMK: 
SPU: 
592507(MAP3K5)
APLC: 
SKO: 
DME: 
DPO: 
Dpse_GA18383(Dpse_Pk92B)
DAN: 
DER: 
Dere_GG23570(Dere_Pk92B)
DPE: 
DSE: 
DSI: 
Dsimw501_GD19320(Dsim_GD19320)
DWI: 
Dwil_GK22362(Dwil_Pk92B)
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
CQU: 
AME: 
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
100529210(ask1)
DPL: 
PXY: 
API: 
DNX: 
PHU: 
FCD: 
ISC: 
TUT: 
CEL: 
CBR: 
CBG02299(Cbr-nsy-1)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
MYI: 
OBI: 
LAK: 
SMM: 
SHX: 
OVI: 
HMG: 
TAD: 
AQU: 
MBR: 
SRE: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Matsuzawa A, Nishitoh H, Tobiume K, Takeda K, Ichijo H
  Title
Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.
  Journal
Antioxid Redox Signal 4:415-25 (2002)
DOI:10.1089/15230860260196218
Reference
PMID:8940179
  Authors
Wang XS, Diener K, Jannuzzi D, Trollinger D, Tan TH, Lichenstein H, Zukowski M, Yao Z
  Title
Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase.
  Journal
J Biol Chem 271:31607-11 (1996)
DOI:10.1074/jbc.271.49.31607
  Sequence
[hsa:4217]

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