KEGG   ORTHOLOGY: K04430Help
Entry
K04430                      KO                                     

Name
MAP2K4, MKK4
Definition
mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
Pathway
MAPK signaling pathway
ErbB signaling pathway
Toll-like receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
GnRH signaling pathway
Epithelial cell signaling in Helicobacter pylori infection
Chagas disease (American trypanosomiasis)
Hepatitis B
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Module
M00688  
MAPK (JNK) signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04012 ErbB signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04668 TNF signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04664 Fc epsilon RI signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  Endocrine system
   04912 GnRH signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
 Human Diseases
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05166 HTLV-I infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05164 Influenza A
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05161 Hepatitis B
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05169 Epstein-Barr virus infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05142 Chagas disease (American trypanosomiasis)
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00688  MAPK (JNK) signaling
     K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: STE group
  STE7 family
   K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
6416(MAP2K4)
PTR: 
455065(MAP2K4)
PPS: 
100991495(MAP2K4)
GGO: 
PON: 
NLE: 
100587718(MAP2K4)
MCC: 
718155(MAP2K4)
MCF: 
102125035(MAP2K4)
CJC: 
100386168(MAP2K4)
MMU: 
26398(Map2k4)
RNO: 
287398(Map2k4)
CGE: 
100770977(Map2k4)
NGI: 
103752052(Map2k4)
HGL: 
101705822(Map2k4)
OCU: 
100344852(MAP2K4)
TUP: 
102493856(MAP2K4)
CFA: 
489508(MAP2K4)
AML: 
UMR: 
103660510(MAP2K4)
FCA: 
101086432(MAP2K4)
PTG: 
102966812(MAP2K4)
BTA: 
526469(MAP2K4)
BOM: 
102287278(MAP2K4)
PHD: 
102333652(MAP2K4)
CHX: 
102175799(MAP2K4)
OAS: 
101115045(MAP2K4)
SSC: 
100520100(MAP2K4)
CFR: 
102513578(MAP2K4)
BACU: 
103012105(MAP2K4)
LVE: 
103091203(MAP2K4)
ECB: 
100073094(MAP2K4)
MYB: 
102244251(MAP2K4)
MYD: 
102769098(MAP2K4)
PALE: 
102894945(MAP2K4)
MDO: 
100019828(MAP2K4)
SHR: 
OAA: 
GGA: 
417312(MAP2K4)
MGP: 
APLA: 
101805315(MAP2K4)
TGU: 
FAB: 
101822010(MAP2K4)
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
102577347(MAP2K4)
PSS: 
CMY: 
ACS: 
100556629(map2k4)
PBI: 
XTR: 
100135013(map2k4)
DRE: 
403052(map2k4a) 568951(map2k4b)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102352547(MAP2K4)
CMK: 
103175698(map2k4)
BFO: 
CIN: 
778672(mapkk4)
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
410575(Mkk4)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG01940(Cbr-mkk-4)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wang X, Destrument A, Tournier C
  Title
Physiological roles of MKK4 and MKK7: insights from animal models.
  Journal
Biochim Biophys Acta 1773:1349-57 (2007)

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