KEGG   ORTHOLOGY: K04447Help
Entry
K04447                      KO                                     

Name
JAK2
Definition
Janus kinase 2 [EC:2.7.10.2]
Pathway
EGFR tyrosine kinase inhibitor resistance
Chemokine signaling pathway
PI3K-Akt signaling pathway
Signaling pathways regulating pluripotency of stem cells
Jak-STAT signaling pathway
Cholinergic synapse
Prolactin signaling pathway
Adipocytokine signaling pathway
AGE-RAGE signaling pathway in diabetic complications
Leishmaniasis
Toxoplasmosis
Tuberculosis
Measles
Influenza A
Herpes simplex infection
Module
M00684  
JAK-STAT signaling
Disease
H00012  
Polycythemia vera
H01433  
Budd-Chiari syndrome
H01481  
Myelodysplastic syndrome
H01605  
Myelofibrosis
H01612  
Essential thrombocytosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K04447  JAK2; Janus kinase 2
   04151 PI3K-Akt signaling pathway
    K04447  JAK2; Janus kinase 2
 Cellular Processes
  Cellular commiunity
   04550 Signaling pathways regulating pluripotency of stem cells
    K04447  JAK2; Janus kinase 2
 Organismal Systems
  Immune system
   04062 Chemokine signaling pathway
    K04447  JAK2; Janus kinase 2
  Endocrine system
   04920 Adipocytokine signaling pathway
    K04447  JAK2; Janus kinase 2
   04917 Prolactin signaling pathway
    K04447  JAK2; Janus kinase 2
  Nervous system
   04725 Cholinergic synapse
    K04447  JAK2; Janus kinase 2
 Human Diseases
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04447  JAK2; Janus kinase 2
  Infectious diseases
   05152 Tuberculosis
    K04447  JAK2; Janus kinase 2
   05162 Measles
    K04447  JAK2; Janus kinase 2
   05164 Influenza A
    K04447  JAK2; Janus kinase 2
   05168 Herpes simplex infection
    K04447  JAK2; Janus kinase 2
   05145 Toxoplasmosis
    K04447  JAK2; Janus kinase 2
   05140 Leishmaniasis
    K04447  JAK2; Janus kinase 2
  Antineoplastic resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04447  JAK2; Janus kinase 2
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00684  JAK-STAT signaling
     K04447  JAK2; Janus kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K04447  JAK2; Janus kinase 2
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  JAK family [OT]
   K04447  JAK2; Janus kinase 2
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
3717(JAK2)
PTR: 
464979(JAK2)
PPS: 
100979742(JAK2)
GGO: 
101149427(JAK2)
PON: 
100172517(JAK2)
NLE: 
100588880(JAK2)
MCC: 
694184(JAK2)
MCF: 
102119008(JAK2)
RRO: 
104665700(JAK2)
CJC: 
100413251(JAK2)
MMU: 
16452(Jak2)
RNO: 
24514(Jak2)
CGE: 
100769337(Jak2)
NGI: 
103740979(Jak2)
HGL: 
101717708(Jak2)
OCU: 
100358134(JAK2)
TUP: 
102502106(JAK2)
CFA: 
484185(JAK2)
AML: 
100481360(JAK2)
UMR: 
103663212(JAK2)
FCA: 
101088959(JAK2)
PTG: 
102950330(JAK2)
BTA: 
525246(JAK2)
BOM: 
102278692(JAK2)
PHD: 
102339850(JAK2)
CHX: 
102180670(JAK2)
OAS: 
101113909(JAK2)
SSC: 
397201(JAK2)
CFR: 
102520220(JAK2)
BACU: 
103016904(JAK2)
LVE: 
103076804(JAK2)
ECB: 
100051487(JAK2)
MYB: 
102253056(JAK2)
MYD: 
102768196(JAK2)
PALE: 
102882079(JAK2)
MDO: 
100017930(JAK2)
SHR: 
100927237(JAK2)
OAA: 
100074305(JAK2)
GGA: 
374199(JAK2)
MGP: 
100548880(JAK2)
CJO: 
APLA: 
101799651(JAK2)
TGU: 
100225452(JAK2)
GFR: 
102037786(JAK2)
FAB: 
101808382(JAK2)
PHI: 
102110768(JAK2)
CCW: 
104685173(JAK2)
FPG: 
101916887(JAK2)
FCH: 
102051463(JAK2)
CLV: 
102095126(JAK2)
AAM: 
106496764(JAK2)
ASN: 
102370961(JAK2)
AMJ: 
102569112(JAK2)
PSS: 
102455115(JAK2)
CMY: 
102932830(JAK2)
ACS: 
100552375(jak2)
PBI: 
103049657(JAK2)
GJA: 
107107201(JAK2)
XLA: 
443637(jak2)
XTR: 
100036599(jak2)
DRE: 
30298(jak2b) 30307(jak2a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
CIN: 
778659(jak)
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
Dyak_GE17301(dyak_GLEANR_18643)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
AME: 
726002(hop)
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
BMOR: 
PXY: 
API: 
PHU: 
ISC: 
CRG: 
TAD: 
VRA: 
MTR: 
ADU: 
AIP: 
PIF: 
PSOJ: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wallace TA, Sayeski PP
  Title
Jak2 tyrosine kinase: a mediator of both housekeeping and ligand-dependent gene expression?
  Journal
Cell Biochem Biophys 44:213-22 (2006)
Reference
PMID:9618263
  Authors
Saltzman A, Stone M, Franks C, Searfoss G, Munro R, Jaye M, Ivashchenko Y
  Title
Cloning and characterization of human Jak-2 kinase: high mRNA expression in immune cells and muscle tissue.
  Journal
Biochem Biophys Res Commun 246:627-33 (1998)
  Sequence
[hsa:3717]

DBGET integrated database retrieval system