KEGG   ORTHOLOGY: K04451Help
Entry
K04451                      KO                                     

Name
TP53, P53
Definition
tumor protein p53
Pathway
MAPK signaling pathway
Cell cycle
p53 signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Wnt signaling pathway
Neurotrophin signaling pathway
Thyroid hormone signaling pathway
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Hepatitis C
Hepatitis B
Measles
HTLV-I infection
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Transcriptional misregulation in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Basal cell carcinoma
Melanoma
Bladder cancer
Chronic myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Disease
H00004  
Chronic myeloid leukemia (CML)
H00005  
Chronic lymphocytic leukemia (CLL)
H00006  
Hairy-cell leukemia
H00008  
Burkitt lymphoma
H00009  
Adult T-cell leukemia
H00010  
Multiple myeloma
H00013  
Small cell lung cancer
H00014  
Non-small cell lung cancer
H00015  
Malignant pleural mesothelioma
H00016  
Oral cancer
H00017  
Esophageal cancer
H00018  
Gastric cancer
H00019  
Pancreatic cancer
H00020  
Colorectal cancer
H00022  
Bladder cancer
H00025  
Penile cancer
H00026  
Endometrial Cancer
H00027  
Ovarian cancer
H00028  
Choriocarcinoma
H00029  
Vulvar cancer
H00031  
Breast cancer
H00032  
Thyroid cancer
H00033  
Adrenal carcinoma
H00036  
Osteosarcoma
H00038  
Malignant melanoma
H00039  
Basal cell carcinoma
H00040  
Squamous cell carcinoma
H00041  
Kaposi's sarcoma
H00042  
Glioma
H00044  
Cancer of the anal canal
H00046  
Cholangiocarcinoma
H00047  
Gallbladder cancer
H00048  
Hepatocellular carcinoma
H00055  
Laryngeal cancer
H00881  
Li-Fraumeni syndrome
H01007  
Choroid plexus papilloma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04451  TP53, P53; tumor protein p53
   04310 Wnt signaling pathway
    K04451  TP53, P53; tumor protein p53
   04151 PI3K-Akt signaling pathway
    K04451  TP53, P53; tumor protein p53
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K04451  TP53, P53; tumor protein p53
   04210 Apoptosis
    K04451  TP53, P53; tumor protein p53
   04115 p53 signaling pathway
    K04451  TP53, P53; tumor protein p53
 Organismal Systems
  Endocrine system
   04919 Thyroid hormone signaling pathway
    K04451  TP53, P53; tumor protein p53
  Nervous system
   04722 Neurotrophin signaling pathway
    K04451  TP53, P53; tumor protein p53
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04451  TP53, P53; tumor protein p53
   05202 Transcriptional misregulation in cancers
    K04451  TP53, P53; tumor protein p53
   05206 MicroRNAs in cancer
    K04451  TP53, P53; tumor protein p53
   05205 Proteoglycans in cancer
    K04451  TP53, P53; tumor protein p53
   05203 Viral carcinogenesis
    K04451  TP53, P53; tumor protein p53
   05210 Colorectal cancer
    K04451  TP53, P53; tumor protein p53
   05212 Pancreatic cancer
    K04451  TP53, P53; tumor protein p53
   05214 Glioma
    K04451  TP53, P53; tumor protein p53
   05216 Thyroid cancer
    K04451  TP53, P53; tumor protein p53
   05220 Chronic myeloid leukemia
    K04451  TP53, P53; tumor protein p53
   05217 Basal cell carcinoma
    K04451  TP53, P53; tumor protein p53
   05218 Melanoma
    K04451  TP53, P53; tumor protein p53
   05219 Bladder cancer
    K04451  TP53, P53; tumor protein p53
   05215 Prostate cancer
    K04451  TP53, P53; tumor protein p53
   05213 Endometrial cancer
    K04451  TP53, P53; tumor protein p53
   05222 Small cell lung cancer
    K04451  TP53, P53; tumor protein p53
   05223 Non-small cell lung cancer
    K04451  TP53, P53; tumor protein p53
  Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    K04451  TP53, P53; tumor protein p53
   05016 Huntington's disease
    K04451  TP53, P53; tumor protein p53
  Infectious diseases
   05166 HTLV-I infection
    K04451  TP53, P53; tumor protein p53
   05162 Measles
    K04451  TP53, P53; tumor protein p53
   05161 Hepatitis B
    K04451  TP53, P53; tumor protein p53
   05160 Hepatitis C
    K04451  TP53, P53; tumor protein p53
   05168 Herpes simplex infection
    K04451  TP53, P53; tumor protein p53
   05169 Epstein-Barr virus infection
    K04451  TP53, P53; tumor protein p53
Transcription factors [BR:ko03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   p53
    K04451  TP53, P53; tumor protein p53
Chromosome [BR:ko03036]
 Eukaryotic Type
  Sister chromatid separation proteins
   Aurora kinases
    Regulators of Aurora kinases
     K04451  TP53, P53; tumor protein p53
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  Check point factors
   Other check point factors
    K04451  TP53, P53; tumor protein p53
BRITE hierarchy
Genes
HSA: 
7157(TP53)
PTR: 
455214(TP53)
PPS: 
100973941(TP53)
GGO: 
101133524(TP53)
PON: 
100435218(TP53)
MCC: 
716170(TP53)
MCF: 
102135998(TP53)
MMU: 
22059(Trp53)
RNO: 
24842(Tp53)
CGE: 
HGL: 
101701769(Tp53)
TUP: 
102503238(TP53)
CFA: 
403869(TP53)
AML: 
FCA: 
493847(TP53)
BTA: 
281542(TP53)
BOM: 
102272370(TP53)
PHD: 
102330970(TP53)
CHX: 
102169621(TP53)
SSC: 
397276(TP53)
ECB: 
100062044(TP53)
MYB: 
102244768(TP53)
MDO: 
497248(TP53)
SHR: 
100922473(TP53)
GGA: 
396200(TP53)
ASN: 
102376594(TP53)
XLA: 
397926(tp53)
XTR: 
431679(tp53)
DRE: 
30590(tp53)
TRU: 
MZE: 
OLA: 
100049321(tp53)
XMA: 
102219062(tp53)
LCM: 
BMOR: 
API: 
ISC: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Goh AM, Coffill CR, Lane DP
  Title
The role of mutant p53 in human cancer.
  Journal
J Pathol 223:116-26 (2011)
Reference
  Authors
Muller PA, Vousden KH, Norman JC
  Title
p53 and its mutants in tumor cell migration and invasion.
  Journal
J Cell Biol 192:209-18 (2011)

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