KEGG   ORTHOLOGY: K04467Help
Entry
K04467                      KO                                     

Name
IKBKA, IKKA, CHUK
Definition
inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
Pathway
MAPK signaling pathway
Ras signaling pathway
Chemokine signaling pathway
NF-kappa B signaling pathway
FoxO signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Osteoclast differentiation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Cytosolic DNA-sensing pathway
T cell receptor signaling pathway
B cell receptor signaling pathway
TNF signaling pathway
Adipocytokine signaling pathway
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Hepatitis C
Hepatitis B
Measles
HTLV-I infection
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Pancreatic cancer
Prostate cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Module
M00686  
Toll-like receptor signaling
Disease
H00882  
Cocoon syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04010 MAPK signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04064 NF-kappa B signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04668 TNF signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04068 FoxO signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04151 PI3K-Akt signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04150 mTOR signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04621 NOD-like receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04622 RIG-I-like receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04623 Cytosolic DNA-sensing pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04660 T cell receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04662 B cell receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04062 Chemokine signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  Endocrine system
   04920 Adipocytokine signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  Development
   04380 Osteoclast differentiation
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05212 Pancreatic cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05221 Acute myeloid leukemia
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05220 Chronic myeloid leukemia
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05215 Prostate cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05222 Small cell lung cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05131 Shigellosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05166 HTLV-I infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05162 Measles
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05161 Hepatitis B
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05160 Hepatitis C
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05168 Herpes simplex infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05169 Epstein-Barr virus infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05145 Toxoplasmosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05142 Chagas disease (American trypanosomiasis)
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00686  Toll-like receptor signaling
     K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: Other group
  IKK family [OT]
   K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
1147(CHUK)
PTR: 
450673(CHUK)
PPS: 
100995228(CHUK)
GGO: 
101137405(CHUK)
PON: 
100174735(CHUK)
NLE: 
100596225(CHUK)
MCC: 
709511(CHUK)
MCF: 
102115964(CHUK)
RRO: 
104656469(CHUK)
CJC: 
100410737(CHUK)
MMU: 
12675(Chuk)
RNO: 
309361(Chuk)
CGE: 
100754432(Chuk)
NGI: 
103743976(Chuk)
HGL: 
101719306(Chuk)
OCU: 
100355888(CHUK)
TUP: 
102501308(CHUK)
CFA: 
477796(CHUK)
AML: 
100464675(CHUK)
UMR: 
103658916(CHUK)
FCA: 
101095617(CHUK)
PTG: 
102949289(CHUK)
BTA: 
281073(CHUK)
BOM: 
102281886(CHUK)
PHD: 
102332461(CHUK)
CHX: 
102181262(CHUK)
OAS: 
101111143(CHUK)
SSC: 
100135662(CHUK)
CFR: 
102503497(CHUK)
BACU: 
103015414(CHUK)
LVE: 
103085220(CHUK)
ECB: 
100070393(CHUK)
MYB: 
102261467(CHUK)
MYD: 
102760888(CHUK)
PALE: 
102879469(CHUK)
MDO: 
100027952(CHUK)
SHR: 
100913624(CHUK)
OAA: 
100082351(CHUK)
GGA: 
423669(CHUK)
MGP: 
100542478(CHUK)
CJO: 
107315625(CHUK)
APLA: 
101801064(CHUK)
TGU: 
GFR: 
102042264(CHUK)
FAB: 
101812706(CHUK)
PHI: 
102107801(CHUK)
CCW: 
104695067(CHUK)
FPG: 
101914413(CHUK)
FCH: 
102053491(CHUK)
CLV: 
102084658(CHUK)
AAM: 
106495295(CHUK)
ASN: 
102374729(CHUK)
AMJ: 
106736873(CHUK)
PSS: 
102454064(CHUK)
CMY: 
102932800(CHUK)
ACS: 
100565922(chuk)
PBI: 
103061898(CHUK)
GJA: 
107117758(CHUK)
XLA: 
444556(chuk)
XTR: 
DRE: 
393287(chuk)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102361819(CHUK)
CMK: 
103181859(chuk)
SKO: 
HRO: 
CRG: 
HMG: 
TAD: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9244310
  Authors
Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M
  Title
Identification and characterization of an IkappaB kinase.
  Journal
Cell 90:373-83 (1997)
  Sequence
[hsa:1147]
Reference
  Authors
Razani B, Zarnegar B, Ytterberg AJ, Shiba T, Dempsey PW, Ware CF, Loo JA, Cheng G
  Title
Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation.
  Journal
Sci Signal 3:ra41 (2010)
  Sequence
[hsa:1147]

DBGET integrated database retrieval system