KEGG   ORTHOLOGY: K04501Help
Entry
K04501                      KO                                     

Name
SMAD4
Definition
mothers against decapentaplegic homolog 4
Pathway
FoxO signaling pathway
Cell cycle
Wnt signaling pathway
TGF-beta signaling pathway
Hippo signaling pathway
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Hepatitis B
HTLV-I infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Chronic myeloid leukemia
Module
M00679  
BMP signaling
M00680  
TGF-beta signaling
M00681  
Activin signaling
Disease
H00019  
Pancreatic cancer
H00020  
Colorectal cancer
H00533  
Hereditary hemorrhagic telangiectasia (HHT)
H01023  
Juvenile polyposis syndrome
H01300  
Primary pulmonary hypertension (PPH)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04350 TGF-beta signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04390 Hippo signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04068 FoxO signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  Cellular commiunity
   04520 Adherens junction
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04550 Signaling pathways regulating pluripotency of stem cells
    K04501  SMAD4; mothers against decapentaplegic homolog 4
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05210 Colorectal cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05212 Pancreatic cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05220 Chronic myeloid leukemia
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  Infectious diseases
   05166 HTLV-I infection
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05161 Hepatitis B
    K04501  SMAD4; mothers against decapentaplegic homolog 4
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00679  BMP signaling
     K04501  SMAD4; mothers against decapentaplegic homolog 4
    M00680  TGF-beta signaling
     K04501  SMAD4; mothers against decapentaplegic homolog 4
    M00681  Activin signaling
     K04501  SMAD4; mothers against decapentaplegic homolog 4
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
4089(SMAD4)
PTR: 
468537(SMAD4)
PPS: 
100991127(SMAD4)
GGO: 
PON: 
100439171(SMAD4)
NLE: 
100599586(SMAD4)
MCC: 
701803(SMAD4)
MCF: 
102142438(SMAD4)
CJC: 
100409302(SMAD4)
MMU: 
17128(Smad4)
RNO: 
50554(Smad4)
CGE: 
100770737(Smad4)
NGI: 
103726635(Smad4)
HGL: 
101703764(Smad4)
OCU: 
100342294(SMAD4)
TUP: 
102494008(SMAD4)
CFA: 
476196(SMAD4)
AML: 
UMR: 
103664305(SMAD4)
FCA: 
101093650(SMAD4)
PTG: 
102961093(SMAD4)
BTA: 
540248(SMAD4)
BOM: 
102265995(SMAD4)
PHD: 
102316189(SMAD4)
CHX: 
100861019(SMAD4)
OAS: 
443171(SMAD4)
SSC: 
397142(SMAD4)
CFR: 
102507868(SMAD4)
BACU: 
103014916(SMAD4)
LVE: 
103084261(SMAD4)
ECB: 
100033846(SMAD4)
MYB: 
MYD: 
102752949(SMAD4)
PALE: 
102886521(SMAD4)
MDO: 
100010143(SMAD4)
SHR: 
OAA: 
100077136(SMAD4)
APLA: 
101805274(SMAD4)
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
102095020(SMAD4)
ASN: 
AMJ: 
PSS: 
102451711(SMAD4)
CMY: 
ACS: 
100552093(smad4)
PBI: 
103061201(SMAD4)
XLA: 
403356(smad4.2-a) 779167 780764(smad4.1)
XTR: 
100038088(smad4.1)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103187334(smad4)
BFO: 
CIN: 
778905(smad4)
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
409321(Smad4)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG08108(Cbr-daf-3) CBG09090(Cbr-sma-4)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9389648
  Authors
Liu F, Pouponnot C, Massague J
  Title
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes.
  Journal
Genes Dev 11:3157-67 (1997)
  Sequence
[hsa:4089]

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