KEGG   ORTHOLOGY: K04501Help
Entry
K04501                      KO                                     

Name
SMAD4
Definition
mothers against decapentaplegic homolog 4
Pathway
FoxO signaling pathway
Cell cycle
Wnt signaling pathway
TGF-beta signaling pathway
Hippo signaling pathway
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Hepatitis B
HTLV-I infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Chronic myeloid leukemia
Disease
H00019  
Pancreatic cancer
H00020  
Colorectal cancer
H00533  
Hereditary hemorrhagic telangiectasia (HHT)
H01023  
Juvenile polyposis syndrome
H01300  
Primary pulmonary hypertension (PPH)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04350 TGF-beta signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04390 Hippo signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04068 FoxO signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  Cellular commiunity
   04520 Adherens junction
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04550 Signaling pathways regulating pluripotency of stem cells
    K04501  SMAD4; mothers against decapentaplegic homolog 4
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05210 Colorectal cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05212 Pancreatic cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05220 Chronic myeloid leukemia
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  Infectious diseases
   05166 HTLV-I infection
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05161 Hepatitis B
    K04501  SMAD4; mothers against decapentaplegic homolog 4
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
4089(SMAD4)
PTR: 
468537(SMAD4)
PPS: 
100991127(SMAD4)
GGO: 
PON: 
100439171(SMAD4)
MCC: 
701803(SMAD4)
MCF: 
102142438(SMAD4)
MMU: 
17128(Smad4)
RNO: 
50554(Smad4)
CGE: 
100770737(Smad4)
HGL: 
101703764(Smad4)
TUP: 
102494008(SMAD4)
CFA: 
476196(SMAD4)
AML: 
FCA: 
101093650(SMAD4)
PTG: 
102961093(SMAD4)
BTA: 
540248(SMAD4)
BOM: 
102265995(SMAD4)
PHD: 
102316189(SMAD4)
CHX: 
100861019(SMAD4)
OAS: 
443171(SMAD4)
SSC: 
397142(SMAD4)
CFR: 
102507868(SMAD4)
BACU: 
103014916(SMAD4)
LVE: 
103084261(SMAD4)
ECB: 
100033846(SMAD4)
MYB: 
MYD: 
102752949(SMAD4)
PALE: 
102886521(SMAD4)
MDO: 
100010143(SMAD4)
SHR: 
OAA: 
100077136(SMAD4)
FAB: 
PHI: 
APLA: 
101805274(SMAD4)
FPG: 
FCH: 
CLV: 
102095020(SMAD4)
ASN: 
AMJ: 
PSS: 
102451711(SMAD4)
CMY: 
ACS: 
PBI: 
103061201(SMAD4)
XLA: 
403356(smad4.2-a) 779167 780764(smad4.1)
XTR: 
100038088(smad4.1)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103187334(smad4)
BFO: 
CIN: 
778905(smad4)
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
409321(Smad4)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG08108(Cbr-daf-3) CBG09090(Cbr-sma-4)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9389648
  Authors
Liu F, Pouponnot C, Massague J
  Title
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes.
  Journal
Genes Dev 11:3157-67 (1997)
  Sequence
[hsa:4089]

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