KEGG   ORTHOLOGY: K04506Help
Entry
K04506                      KO                                     
Name
SIAH1
Definition
E3 ubiquitin-protein ligase SIAH1 [EC:6.3.2.19]
Pathway
p53 signaling pathway
Ubiquitin mediated proteolysis
Wnt signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04506  SIAH1; E3 ubiquitin-protein ligase SIAH1
 Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K04506  SIAH1; E3 ubiquitin-protein ligase SIAH1
 Cellular Processes
  Cell growth and death
   04115 p53 signaling pathway
    K04506  SIAH1; E3 ubiquitin-protein ligase SIAH1
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.19  ubiquitin---protein ligase
     K04506  SIAH1; E3 ubiquitin-protein ligase SIAH1
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  single Ring-finger type E3
   SINA (Seven in absentia) proteins
    K04506  SIAH1; E3 ubiquitin-protein ligase SIAH1
BRITE hierarchy
Genes
HSA: 
6477(SIAH1)
PTR: 
465153(SIAH1) 473557
PPS: 
GGO: 
PON: 
MCC: 
694921(SIAH1) 716629(SIAH1)
MMU: 
20437(Siah1a) 20438(Siah1b)
RNO: 
140941(Siah1a)
CFA: 
AML: 
FCA: 
101090311(SIAH1)
BTA: 
534655(SIAH1)
SSC: 
100520614 100737574
ECB: 
100057532
MDO: 
100016498(SIAH1)
SHR: 
100922952(SIAH1)
OAA: 
100682095
GGA: 
374076(SIAH1)
MGP: 
100549528
TGU: 
100222788(SIAH1)
ACS: 
100555807
XLA: 
443864(siah1)
XTR: 
548553(siah1)
DRE: 
80955(siah1)
TRU: 
101074163
OLA: 
101155925
BFO: 
BRAFLDRAFT_129882
CIN: 
100176189
SPU: 
592708
DME: 
Dmel_CG13030(sinah) Dmel_CG9949(sina)
DPO: 
Dpse_GA11985 Dpse_GA22147
DAN: 
Dana_GF23936 Dana_GF23937
DER: 
Dere_GG13584(Dere_sina) Dere_GG13585
DPE: 
Dper_GL20852 Dper_GL20853
DSE: 
Dsec_GM25664 Dsec_GM25665
DSI: 
Dsim_GD14671 Dsim_GD14672
DWI: 
Dwil_GK20872(Dwil_sina) Dwil_GK20883
DYA: 
Dyak_GE19881 Dyak_GE19882
DGR: 
Dgri_GH16597 Dgri_GH16598
DMO: 
Dmoj_GI12443 Dmoj_GI12444
DVI: 
Dvir_GJ12342(Dvir_sina) Dvir_GJ12343
AGA: 
AgaP_AGAP006127
AAG: 
AaeL_AAEL009614
CQU: 
CpipJ_CPIJ009247
AME: 
410808(sina)
NVI: 
100119052(NV13902)
TCA: 
100142282 660139
API: 
100164664
PHU: 
Phum_PHUM333800
ISC: 
IscW_ISCW015643
CEL: 
CELE_Y37E11AR.2(siah-1)
CBR: 
CBG08288(Cbr-siah-1)
BMY: 
Bm1_36670
TSP: 
Tsp_03055
SMM: 
Smp_000650
NVE: 
NEMVE_v1g93606
HMG: 
100204840
AQU: 
100639566
ATH: 
AT2G41980 AT3G58040(SINAT2) AT3G61790 AT4G27880
ALY: 
ARALYDRAFT_486680 ARALYDRAFT_657285 ARALYDRAFT_903543 ARALYDRAFT_907274
GMX: 
100500061 100778869 100779238 100781022 100793457 100810573
MTR: 
MTR_1g008120 MTR_3g017590 MTR_3g091510 MTR_7g093600 MTR_8g038370
CSV: 
101205198 101213438 101220834 101228366 101230083 101230820
RCU: 
RCOM_0326980 RCOM_0446280 RCOM_0718310 RCOM_1242610 RCOM_1452850
POP: 
POPTR_1072377 POPTR_555252 POPTR_711983 POPTR_716975 POPTR_750490 POPTR_823211
VVI: 
100233084 100233085 100244678 100252009 100260463 100262215 100267231
OSA: 
4327774 4328179 4329066 4340862 4344172 9266295 9269391
DOSA: 
Os01t0125500-00(Os01g0125500) Os01t0234900-01(Os01g0234900) Os02t0128800-01(Os02g0128800) Os02t0293400-01(Os02g0293400) Os03t0356414-01(Os03g0356414) Os06t0311300-01(Os06g0311300) Os07t0659800-01(Os07g0659800)
BDI: 
100823045 100826252 100832893 100833057 100837925 100838500
SBI: 
SORBI_01g035070(SORBIDRAFT_01g035070) SORBI_02g041870(SORBIDRAFT_02g041870) SORBI_04g002390(SORBIDRAFT_04g002390) SORBI_04g011560(SORBIDRAFT_04g011560) SORBI_08g006830(SORBIDRAFT_08g006830)
ZMA: 
100170243(cl5847_1) 100170244 100170245 100217140 100273809 100279741
SMO: 
SELMODRAFT_119614(SINAT5A-2) SELMODRAFT_268881(SINAT5B-2) SELMODRAFT_97849(SINAT5A-1)
PPP: 
PHYPADRAFT_206770 PHYPADRAFT_215197 PHYPADRAFT_25870
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Venables JP, Dalgliesh C, Paronetto MP, Skitt L, Thornton JK, Saunders PT, Sette C, Jones KT, Elliott DJ
  Title
SIAH1 targets the alternative splicing factor T-STAR for degradation by the proteasome.
  Journal
Hum Mol Genet 13:1525-34 (2004)
Reference
  Authors
Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, Ely KR, Reed JC, Pellecchia M, Liddington RC, Matsuzawa S
  Title
Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex.
  Journal
J Biol Chem 280:34278-87 (2005)
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