KEGG   ORTHOLOGY: K04526Help
Entry
K04526                      KO                                     

Name
INS
Definition
insulin
Pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
Oocyte meiosis
Regulation of autophagy
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Regulation of actin cytoskeleton
Insulin signaling pathway
Insulin secretion
Ovarian steroidogenesis
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Type I diabetes mellitus
Maturity onset diabetes of the young
Aldosterone-regulated sodium reabsorption
Prostate cancer
Disease
H00408  
Type I diabetes mellitus
H00410  
Maturity onset diabetes of the young (MODY)
H00512  
Permanent neonatal diabetes mellitus (PNDM)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04526  INS; insulin
   04015 Rap1 signaling pathway
    K04526  INS; insulin
   04066 HIF-1 signaling pathway
    K04526  INS; insulin
   04068 FoxO signaling pathway
    K04526  INS; insulin
   04072 Phospholipase D signaling pathway
    K04526  INS; insulin
   04022 cGMP - PKG signaling pathway
    K04526  INS; insulin
   04151 PI3K-Akt signaling pathway
    K04526  INS; insulin
   04152 AMPK signaling pathway
    K04526  INS; insulin
   04150 mTOR signaling pathway
    K04526  INS; insulin
 Cellular Processes
  Transport and catabolism
   04140 Regulation of autophagy
    K04526  INS; insulin
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04526  INS; insulin
  Cell growth and death
   04114 Oocyte meiosis
    K04526  INS; insulin
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    K04526  INS; insulin
   04910 Insulin signaling pathway
    K04526  INS; insulin
   04923 Regulation of lipolysis in adipocyte
    K04526  INS; insulin
   04913 Ovarian Steroidogenesis
    K04526  INS; insulin
   04914 Progesterone-mediated oocyte maturation
    K04526  INS; insulin
   04917 Prolactin signaling pathway
    K04526  INS; insulin
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K04526  INS; insulin
  Aging
   04211 Longevity regulating pathway - mammal
    K04526  INS; insulin
   04213 Longevity regulating pathway - multiple species
    K04526  INS; insulin
 Human Diseases
  Cancers
   05215 Prostate cancer
    K04526  INS; insulin
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K04526  INS; insulin
   04940 Type I diabetes mellitus
    K04526  INS; insulin
   04950 Maturity onset diabetes of the young
    K04526  INS; insulin
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04526  INS; insulin
   04931 Insulin resistance
    K04526  INS; insulin
BRITE hierarchy
Genes
HSA: 
3630(INS)
PTR: 
449570(INS)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
704534(INS)
MCF: 
RRO: 
CJC: 
MMU: 
16333(Ins1) 16334(Ins2)
RNO: 
24505(Ins1) 24506(Ins2)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
483665(INS)
AML: 
UMR: 
FCA: 
493804(INS)
BTA: 
280829(INS)
BOM: 
SSC: 
397415(INS)
BACU: 
LVE: 
MYB: 
MYD: 
PALE: 
GGA: 
396145(INS)
MGP: 
CJO: 
APLA: 
TGU: 
GFR: 
FAB: 
PHI: 
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
GJA: 
XLA: 
378695(ins-b) 378696(ins-a)
XTR: 
DRE: 
30262(ins) 566735(insb)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD12890(Dsim_GD12890) Dsimw501_GD12891(Dsim_GD12891) Dsimw501_GD12892(Dsim_GD12892) Dsimw501_GD14217(Dsim_GD14217) Dsimw501_GD14218(Dsim_GD14218)
DWI: 
DYA: 
Dyak_GE20299(dyak_GLEANR_4141) Dyak_GE20300(Dyak_Ilp4) Dyak_GE20301(dyak_GLEANR_4143) Dyak_GE21719(dyak_GLEANR_5458) Dyak_GE21720(dyak_GLEANR_5459)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
100146109(Bbx-e1) 100146110(Bbx-f1) 100169708(Bbx-a7) 100169712(Bbx-a3) 100169726(Bbx-g1) 100653512(BmILP) 101741759
PXY: 
API: 
ISC: 
TSP: 
LGI: 
CRG: 
OBI: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Lizcano JM, Alessi DR
  Title
The insulin signalling pathway.
  Journal
Curr Biol 12:R236-8 (2002)
Reference
PMID:2397023
  Authors
Sawa T, Ohgaku S, Morioka H, Yano S
  Title
Molecular cloning and DNA sequence analysis of preproinsulin genes in the NON mouse, an animal model of human non-obese, non-insulin-dependent diabetes mellitus.
  Journal
J Mol Endocrinol 5:61-7 (1990)
  Sequence
[mmu:16333 16334]

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