KEGG   ORTHOLOGY: K04659Help
Entry
K04659                      KO                                     

Name
THBS2S
Definition
thrombospondin 2/3/4/5
Pathway
Phagosome
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Malaria
Disease
H00476  
Multiple epiphyseal dysplasia (MED)
H00477  
Pseudoachondroplasia (PSACH)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K04659  THBS2S; thrombospondin 2/3/4/5
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K04659  THBS2S; thrombospondin 2/3/4/5
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    K04659  THBS2S; thrombospondin 2/3/4/5
  Cellular commiunity
   04510 Focal adhesion
    K04659  THBS2S; thrombospondin 2/3/4/5
 Human Diseases
  Infectious diseases
   05144 Malaria
    K04659  THBS2S; thrombospondin 2/3/4/5
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K04659  THBS2S; thrombospondin 2/3/4/5
  Exosomal proteins of colorectal cancer cells
   K04659  THBS2S; thrombospondin 2/3/4/5
  Exosomal proteins of bladder cancer cells
   K04659  THBS2S; thrombospondin 2/3/4/5
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-3
    ITGB1; integrin beta 1
     K04659 THBS2S; thrombospondin 2/3/4/5
  Beta3 integrins
   alpha IIb  beta 3
    ITGB3; integrin beta 3
     K04659 THBS2S; thrombospondin 2/3/4/5
   VNR
    ITGB3; integrin beta 3
     K04659 THBS2S; thrombospondin 2/3/4/5
 7. Others
  SDC4; syndecan 4
   K04659 THBS2S; thrombospondin 2/3/4/5
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Extracellular matrix molecules
   K04659  THBS2S; thrombospondin 2/3/4/5
BRITE hierarchy
Genes
HSA: 
1311(COMP) 7058(THBS2) 7059(THBS3) 7060(THBS4)
PTR: 
450172(THBS4) 457359(THBS3) 463138(THBS2) 469068(COMP)
PPS: 
100967906(COMP) 100978289(THBS4) 100985431(THBS3) 100991072(THBS2)
GGO: 
101128581(THBS4) 101149083(THBS3) 101150111(THBS2) 101152032(COMP)
PON: 
100443331(THBS3) 100447159(COMP) 100461836(THBS4)
NLE: 
100580032(THBS2) 100582320(COMP) 100588927(THBS4) 100593174(THBS3)
MCC: 
574276(THBS4) 708165(THBS2) 717572(THBS3) 720286(COMP)
MCF: 
101867220(COMP) 102120028(THBS3) 102125342(THBS2) 102129227(THBS4)
RRO: 
104659600(THBS3) 104680172(THBS4) 104680632(COMP) 104681915(THBS2)
CJC: 
100391538(THBS4) 100391690 100397101(THBS3) 100401976(THBS2)
MMU: 
12845(Comp) 21826(Thbs2) 21827(Thbs3) 21828(Thbs4)
RNO: 
25304(Comp) 29220(Thbs4) 292406(Thbs2) 681309(Thbs3)
CGE: 
100752022(Thbs2) 100756924(Thbs3) 100762358(Thbs4) 100766091(Comp)
NGI: 
103726858(Comp) 103742336(Thbs2) 103750279(Thbs4) 103750946(Thbs3)
HGL: 
101696497(Thbs2) 101703996(Comp) 101704466(Thbs3) 101726773(Thbs4)
OCU: 
TUP: 
102476294(COMP) 102485527(THBS4) 102489246(Mucin-1) 102502758(THBS2)
CFA: 
476665(COMP) 484087(THBS2) 488930(THBS4) 610359(THBS3)
AML: 
100471588(THBS4) 100475917(THBS3) 100479895(COMP) 100481026(THBS2)
UMR: 
103660792(THBS2) 103668378(THBS3) 103674931(COMP) 103681497(THBS4)
FCA: 
101087199(THBS4) 101088820(COMP) 101093580(THBS3) 101100567(THBS2) 105260187
PTG: 
102961939(THBS4) 102970054(THBS2) 102970726(THBS3) 102971808(COMP)
BTA: 
281088(COMP) 338092(THBS2) 504323(THBS3) 541281(THBS4)
BOM: 
102267028(COMP) 102271065(THBS3) 102277745 102284714(THBS4) 106701188(THBS2)
PHD: 
102321875(THBS3) 102325197(THBS4) 102331784(THBS2) 102337395(COMP)
CHX: 
102179674(THBS2) 102179675(THBS4) 102190117(COMP) 102190652(THBS3)
OAS: 
101107864(COMP) 101115211(THBS4) 101116784(THBS3) 101116840(THBS2) 105606081
SSC: 
100153940(THBS2) 100155108(THBS3) 100513005(THBS4) 396554(COMP)
CFR: 
102511726(COMP) 102513826(THBS2) 102520625(THBS3) 102524625(THBS4)
BACU: 
102998613(THBS4) 102999752(THBS2) 103007252(COMP) 103007962(THBS3)
LVE: 
103068905(THBS3) 103083668(THBS4) 103086398(THBS2) 103090939(COMP)
ECB: 
100033911(COMP) 100050044(THBS2) 100063449(THBS3) 100073261(THBS4)
MYB: 
102242389(THBS2) 102248184(THBS4) 102249845(COMP) 102250634(THBS3)
MYD: 
102752804(THBS4) 102759156(THBS3) 102759906(THBS2) 102770367(COMP)
PALE: 
102880862(THBS2) 102885384(COMP) 102890277(THBS3) 102898345(THBS4)
MDO: 
100016186(COMP) 100022025(THBS3) 100032579(THBS4) 100032659(THBS2)
SHR: 
100913793(THBS2) 100926884(THBS4) 100928896(THBS3) 100934583(COMP)
OAA: 
100082089(THBS2)
GGA: 
396306(THBS4) 414837(THBS2) 420120(COMP)
MGP: 
100545155(THBS2) 100548314(COMP)
APLA: 
101797309(THBS3) 101797964(THBS2) 101801619(THBS4) 101803344(COMP)
TGU: 
100217632(THBS3) 100221289(THBS2) 100223523(THBS4)
GFR: 
102035426(COMP) 102041416(THBS3) 102042662(THBS2) 102043756(THBS4)
FAB: 
101807800(COMP) 101812668(THBS4) 101813407(THBS2) 101822081(THBS3)
PHI: 
102105229(THBS2) 102107320(COMP) 102111962(THBS3) 102113828(THBS4)
CCW: 
104683533(THBS3) 104684330(THBS2) 104695692(THBS4) 104697387(COMP)
FPG: 
101920098(THBS4) 101921164(THBS3) 101923157(THBS2) 101923991(COMP)
FCH: 
102046521(THBS3) 102049450(THBS4) 102058509(COMP) 102059472(THBS2)
CLV: 
102088266(THBS2) 102095550(THBS3) 102097761(THBS4) 102098894(COMP)
ASN: 
102368490(THBS2) 102376216(COMP) 102384190(THBS4) 102388282(THBS3)
AMJ: 
102565816(THBS3) 102573791(THBS4) 102576627(THBS2) 106737012(COMP) 106737441
PSS: 
CMY: 
102939257(COMP) 102941449(THBS2) 102942106(THBS3) 102946626(THBS4)
ACS: 
100559567(thbs3) 100563584(thbs2) 100563715(thbs4) 100564230(comp)
PBI: 
XLA: 
380339(thbs3) 397943(thbs4) 446985(thbs4)
XTR: 
100494714(comp) 100494997(thbs2) 496875(thbs3) 780130(thbs4)
DRE: 
100318854 100535241(thbs2) 252849(thbs3a) 252850(thbs4b) 563429(thbs4a)
TRU: 
101070052 101071532(comp) 101075106(thbs4) 101077022(thbs2) 101079662(thbs3)
MZE: 
OLA: 
XMA: 
LCM: 
102345222(THBS4) 102349677(THBS3) 102360244(COMP) 102363612(THBS2)
CMK: 
BFO: 
CIN: 
100169670(thbsb)
SPU: 
576669(thbs3) 585488
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
Dyak_GE18413(dyak_GLEANR_2203) Dyak_GE28573
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
413782(Tsp)
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
PXY: 
API: 
PHU: 
ISC: 
HRO: 
LGI: 
CRG: 
OBI: 
NVE: 
HMG: 
TAD: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Christopherson KS, Ullian EM, Stokes CC, Mullowney CE, Hell JW, Agah A, Lawler J, Mosher DF, Bornstein P, Barres BA
  Title
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis.
  Journal
Cell 120:421-33 (2005)

DBGET integrated database retrieval system