KEGG   ORTHOLOGY: K04662Help
Entry
K04662                      KO                                     

Name
BMP4
Definition
bone morphogenetic protein 4
Pathway
ko04013  MAPK signaling pathway - fly
ko04341  Hedgehog signaling pathway - fly
ko04350  TGF-beta signaling pathway
ko04390  Hippo signaling pathway
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04919  Thyroid hormone signaling pathway
ko05200  Pathways in cancer
ko05217  Basal cell carcinoma
ko05418  Fluid shear stress and atherosclerosis
Module
M00679  BMP signaling
Disease
H00516  Cleft lip and/or cleft palate
H01027  Anophthalmia and microphthalmia (A/M)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04013 MAPK signaling pathway - fly
    K04662  BMP4; bone morphogenetic protein 4
   04341 Hedgehog signaling pathway - fly
    K04662  BMP4; bone morphogenetic protein 4
   04350 TGF-beta signaling pathway
    K04662  BMP4; bone morphogenetic protein 4
   04390 Hippo signaling pathway
    K04662  BMP4; bone morphogenetic protein 4
 Cellular Processes
  Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04662  BMP4; bone morphogenetic protein 4
 Organismal Systems
  Endocrine system
   04919 Thyroid hormone signaling pathway
    K04662  BMP4; bone morphogenetic protein 4
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04662  BMP4; bone morphogenetic protein 4
   05217 Basal cell carcinoma
    K04662  BMP4; bone morphogenetic protein 4
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04662  BMP4; bone morphogenetic protein 4
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00679  BMP signaling
     K04662  BMP4; bone morphogenetic protein 4
Cytokines and growth factors [BR:ko04052]
 Cytokines
  Transforming growth factors (RSTK binding)
   K04662  BMP4; bone morphogenetic protein 4
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Morphogens
   K04662  BMP4; bone morphogenetic protein 4
BRITE hierarchy
Other DBs
GO: 0070700
Genes
HSA: 652(BMP4)
PTR: 107968170(BMP4)
PPS: 100987443(BMP4)
GGO: 101126138(BMP4) 101126961
PON: 100449444(BMP4)
NLE: 100586277(BMP4)
MCC: 694618(BMP4)
MCF: 102132568(BMP4)
CSAB: 103229007(BMP4)
RRO: 104669157(BMP4)
CJC: 100398270(BMP4)
SBQ: 101038031(BMP4)
MMU: 12159(Bmp4)
RNO: 25296(Bmp4)
CGE: 100754303(Bmp4)
NGI: 103739231(Bmp4)
HGL: 101711207(Bmp4)
CCAN: 109701382(Bmp4)
OCU: 100009569(BMP4)
TUP: 102497487(BMP4)
CFA: 490695(BMP4)
AML: 100477715(BMP4)
UMR: 103672975(BMP4)
ORO: 101380696(BMP4)
FCA: 101100311(BMP4)
PTG: 102950088(BMP4)
AJU: 106983046(BMP4)
BTA: 407216(BMP4)
BOM: 102266106(BMP4)
BIU: 109565174(BMP4)
PHD: 102336830(BMP4)
CHX: 100860789(BMP4)
OAS: 443502(BMP4)
SSC: 100113425(BMP4)
CFR: 102509507(BMP4)
CDK: 105091431(BMP4)
BACU: 103010740(BMP4)
LVE: 103072786(BMP4)
OOR: 101278431(BMP4)
ECB: 100034048(BMP4)
EPZ: 103558707(BMP4)
EAI: 106846123(BMP4)
MYB: 102262406(BMP4)
MYD: 102769625(BMP4) 102770741
HAI: 109384420(BMP4)
RSS: 109444373(BMP4)
PALE: 102881920(BMP4)
LAV: 100654115(BMP4)
TMU: 101356019
MDO: 100010652(BMP4)
SHR: 100916609(BMP4)
GGA: 396165(BMP4)
MGP: 100544182(BMP4)
CJO: 107315532(BMP4)
APLA: 101803077(BMP4)
ACYG: 106044053(BMP4)
TGU: 100221891(BMP4)
GFR: 102044724(BMP4)
FAB: 101816834(BMP4)
PHI: 102110411(BMP4)
PMAJ: 107205267(BMP4)
CCW: 104687658(BMP4)
FPG: 101923141(BMP4)
FCH: 102047171(BMP4)
CLV: 102098788(BMP4)
EGZ: 104122989(BMP4)
AAM: 106494596(BMP4)
ASN: 102371622(BMP4)
AMJ: 102573848(BMP4)
PSS: 102459846(BMP4)
CMY: 102932745(BMP4)
CPIC: 101949490(BMP4)
ACS: 100567033(bmp4)
PVT: 110089746(BMP4)
PBI: 103054912(BMP4)
GJA: 107118494(BMP4)
XLA: 397874(bmp4.L) 399322(bmp4.S)
XTR: 549788(bmp4)
NPR: 108788625(BMP4)
DRE: 30612(bmp4)
IPU: 108270422(bmp4)
AMEX: 103024384(bmp4)
TRU: 101061931(bmp4)
LCO: 104922404(bmp4)
NCC: 104964390(bmp4)
MZE: 101478902(bmp4)
OLA: 100049354(bmp4)
XMA: 102236800(bmp4)
PRET: 103458754(bmp4)
NFU: 107392164(bmp4)
CSEM: 103378831(bmp4)
LCF: 108875064(bmp4)
HCQ: 109509080 109517481(bmp4)
BPEC: 110153633(bmp4)
SASA: 100194815(bmp4) 106611121
ELS: 105015523(bmp4)
SFM: 108919383(bmp4) 108924036
LCM: 102365184(BMP4)
CMK: 103175246(bmp4)
SKO: 100329085
DME: Dmel_CG9885(dpp)
DPO: Dpse_GA22099(Dpse_dpp)
DER: Dere_GG24858(Dere_dpp)
DSI: Dsimw501_GD23157(Dsim_dpp)
DYA: Dyak_GE18157(Dyak_dpp)
DVI: Dvir_GJ17292(Dvir_dpp)
MDE: 101892832
AAG: 5572653
AME: 727101(dpp)
BIM: 100748741
BTER: 100646366
SOC: 105202003
AEC: 105148754
ACEP: 105627064
PBAR: 105427703
HST: 105180468
CFO: 105252168
LHU: 105672334
PGC: 109861453
NVI: 100123906(dpp)
TCA: 654513(Dpp)
BMOR: 100270781(Dpp)
PMAC: 106715051
PRAP: 111000988
ZNE: 110828339
CEL: CELE_T25F10.2(dbl-1)
CBR: CBG19011(Cbr-dbl-1)
BMY: Bm1_52060
LAK: 106163298
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Tanaka K, Kaji H, Yamaguchi T, Kanazawa I, Canaff L, Hendy GN, Sugimoto T
  Title
Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2alpha-ATF4 pathway in the commitment of myoblastic into osteoblastic cells.
  Journal
Calcif Tissue Int 94:454-64 (2014)
DOI:10.1007/s00223-013-9828-1
Reference
  Authors
Hens JR, Dann P, Zhang JP, Harris S, Robinson GW, Wysolmerski J
  Title
BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.
  Journal
Development 134:1221-30 (2007)
DOI:10.1242/dev.000182
  Sequence
[mmu:12159]

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