KEGG   ORTHOLOGY: K04662Help
Entry
K04662                      KO                                     

Name
BMP2_4
Definition
bone morphogenetic protein 2/4
Pathway
Cytokine-cytokine receptor interaction
Hedgehog signaling pathway
TGF-beta signaling pathway
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
Pathways in cancer
Basal cell carcinoma
Disease
H00516  
Isolated orofacial clefts
H01027  
Anophthalmia and microphthalmia (A/M)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04340 Hedgehog signaling pathway
    K04662  BMP2_4; bone morphogenetic protein 2/4
   04350 TGF-beta signaling pathway
    K04662  BMP2_4; bone morphogenetic protein 2/4
   04390 Hippo signaling pathway
    K04662  BMP2_4; bone morphogenetic protein 2/4
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04662  BMP2_4; bone morphogenetic protein 2/4
 Cellular Processes
  Cellular commiunity
   04550 Signaling pathways regulating pluripotency of stem cells
    K04662  BMP2_4; bone morphogenetic protein 2/4
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04662  BMP2_4; bone morphogenetic protein 2/4
   05217 Basal cell carcinoma
    K04662  BMP2_4; bone morphogenetic protein 2/4
Cytokines [BR:ko04052]
 TGF-beta family
  BMP2 subfamily
   K04662  BMP2_4; bone morphogenetic protein 2/4
Heparan sulfate/heparin binding proteins [BR:ko00536]
 Morphogens
  K04662  BMP2_4; bone morphogenetic protein 2/4
BRITE hierarchy
Genes
HSA: 
650(BMP2) 652(BMP4)
PTR: 
452912(BMP4) 458090(BMP2)
PPS: 
100967346(BMP2) 100987443(BMP4)
GGO: 
PON: 
100449444(BMP4) 100460853(BMP2)
MCC: 
694618(BMP4) 718330(BMP2)
MCF: 
102132568(BMP4) 102145501(BMP2)
MMU: 
12156(Bmp2) 12159(Bmp4)
RNO: 
25296(Bmp4) 29373(Bmp2)
CGE: 
100752564(Bmp2) 100754303(Bmp4)
HGL: 
101711207(Bmp4) 101723419(Bmp2)
TUP: 
CFA: 
477162(BMP2) 490695(BMP4)
AML: 
FCA: 
100301987(BMP2) 101100311(BMP4)
PTG: 
102950088(BMP4) 102961685(BMP2)
BTA: 
407216(BMP4) 615037(BMP2)
BOM: 
102266106(BMP4) 102268860(BMP2)
PHD: 
CHX: 
100860789(BMP4) 100860831(BMP2)
OAS: 
101117688(BMP2) 443502(BMP4)
SSC: 
CFR: 
102509507(BMP4) 102514653(BMP2)
BACU: 
103004284(BMP2) 103010740(BMP4)
LVE: 
103070700(BMP2) 103072786(BMP4)
ECB: 
100034048(BMP4) 100051701(BMP2)
MYB: 
102241256(BMP2) 102262406(BMP4)
MYD: 
PALE: 
102881920(BMP4) 102886941(BMP2)
MDO: 
100010652(BMP4) 100031674(BMP2)
SHR: 
100916609(BMP4) 100935094(BMP2)
OAA: 
100084030(BMP2)
GGA: 
378779(BMP2) 396165(BMP4)
MGP: 
TGU: 
100218108(BMP2) 100221891(BMP4)
FAB: 
101816355(BMP2) 101816834(BMP4)
PHI: 
102101225(BMP2) 102110411(BMP4)
APLA: 
101803077(BMP4) 101805386(BMP2)
FPG: 
101922026(BMP2) 101923141(BMP4)
FCH: 
102047171(BMP4) 102048793(BMP2)
CLV: 
102083678(BMP2) 102098788(BMP4)
ASN: 
AMJ: 
102564323(BMP2) 102573848(BMP4)
PSS: 
102455280(BMP2) 102459846(BMP4)
CMY: 
ACS: 
100560955(bmp2) 100567033(bmp4)
PBI: 
XLA: 
397873(bmp2-b) 397874(bmp4-a) 399322(bmp4-b)
XTR: 
548717(bmp2) 549788(bmp4)
DRE: 
30612(bmp4) 30632(bmp2b)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
778554(bmp2/4)
SPU: 
373196(BMP2/4)
DME: 
DPO: 
Dpse_GA22099(Dpse_dpp)
DAN: 
DER: 
Dere_GG24858(Dere_dpp)
DPE: 
DSE: 
DSI: 
Dsim_GD23157(Dsim_dpp)
DWI: 
DYA: 
Dyak_GE18157(Dyak_dpp)
DGR: 
DMO: 
DVI: 
Dvir_GJ17292(Dvir_dpp)
AGA: 
AAG: 
CQU: 
AME: 
727101(dpp)
NVI: 
TCA: 
654513(Dpp)
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG19011(Cbr-dbl-1)
BMY: 
LOA: 
NVE: 
TAD: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Schmierer B, Hill CS
  Title
TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility.
  Journal
Nat Rev Mol Cell Biol 8:970-82 (2007)
Reference
PMID:9759503
  Authors
Massague J.
  Title
TGF-beta signal transduction.
  Journal
Annu Rev Biochem 67:753-91 (1998)

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