KEGG   ORTHOLOGY: K04662Help
Entry
K04662                      KO                                     

Name
BMP2_4
Definition
bone morphogenetic protein 2/4
Pathway
Cytokine-cytokine receptor interaction
Hedgehog signaling pathway
TGF-beta signaling pathway
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
Pathways in cancer
Basal cell carcinoma
Module
M00679  
BMP signaling
Disease
H00516  
Isolated orofacial clefts
H01027  
Anophthalmia and microphthalmia (A/M)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04340 Hedgehog signaling pathway
    K04662  BMP2_4; bone morphogenetic protein 2/4
   04350 TGF-beta signaling pathway
    K04662  BMP2_4; bone morphogenetic protein 2/4
   04390 Hippo signaling pathway
    K04662  BMP2_4; bone morphogenetic protein 2/4
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04662  BMP2_4; bone morphogenetic protein 2/4
 Cellular Processes
  Cellular commiunity
   04550 Signaling pathways regulating pluripotency of stem cells
    K04662  BMP2_4; bone morphogenetic protein 2/4
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04662  BMP2_4; bone morphogenetic protein 2/4
   05217 Basal cell carcinoma
    K04662  BMP2_4; bone morphogenetic protein 2/4
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00679  BMP signaling
     K04662  BMP2_4; bone morphogenetic protein 2/4
Cytokines [BR:ko04052]
 TGF-beta family
  BMP2 subfamily
   K04662  BMP2_4; bone morphogenetic protein 2/4
Heparan sulfate/heparin binding proteins [BR:ko00536]
 Morphogens
  K04662  BMP2_4; bone morphogenetic protein 2/4
BRITE hierarchy
Genes
HSA: 
650(BMP2) 652(BMP4)
PTR: 
452912(BMP4) 458090(BMP2)
PPS: 
100967346(BMP2) 100987443(BMP4)
GGO: 
PON: 
100449444(BMP4) 100460853(BMP2)
NLE: 
100586277(BMP4) 100586297(BMP2)
MCC: 
694618(BMP4) 718330(BMP2)
MCF: 
102132568(BMP4) 102145501(BMP2)
CJC: 
100398270(BMP4) 100408260(BMP2)
MMU: 
12156(Bmp2) 12159(Bmp4)
RNO: 
25296(Bmp4) 29373(Bmp2)
CGE: 
100752564(Bmp2) 100754303(Bmp4)
NGI: 
103725543(Bmp2) 103739231(Bmp4)
HGL: 
101711207(Bmp4) 101723419(Bmp2)
OCU: 
100009349(BMP2) 100009569(BMP4)
TUP: 
CFA: 
477162(BMP2) 490695(BMP4)
AML: 
UMR: 
103672975(BMP4) 103674423(BMP2)
FCA: 
100301987(BMP2) 101100311(BMP4)
PTG: 
102950088(BMP4) 102961685(BMP2)
BTA: 
407216(BMP4) 615037(BMP2)
BOM: 
102266106(BMP4) 102268860(BMP2)
PHD: 
CHX: 
100860789(BMP4) 100860831(BMP2)
OAS: 
101117688(BMP2) 443502(BMP4)
SSC: 
CFR: 
102509507(BMP4) 102514653(BMP2)
BACU: 
103004284(BMP2) 103010740(BMP4)
LVE: 
103070700(BMP2) 103072786(BMP4)
ECB: 
100034048(BMP4) 100051701(BMP2)
MYB: 
102241256(BMP2) 102262406(BMP4)
MYD: 
PALE: 
102881920(BMP4) 102886941(BMP2)
MDO: 
100010652(BMP4) 100031674(BMP2)
SHR: 
100916609(BMP4) 100935094(BMP2)
OAA: 
100084030(BMP2)
GGA: 
378779(BMP2) 396165(BMP4)
MGP: 
APLA: 
101803077(BMP4) 101805386(BMP2)
TGU: 
100218108(BMP2) 100221891(BMP4)
FAB: 
101816355(BMP2) 101816834(BMP4)
PHI: 
102101225(BMP2) 102110411(BMP4)
FPG: 
101922026(BMP2) 101923141(BMP4)
FCH: 
102047171(BMP4) 102048793(BMP2)
CLV: 
102083678(BMP2) 102098788(BMP4)
ASN: 
AMJ: 
102564323(BMP2) 102573848(BMP4)
PSS: 
102455280(BMP2) 102459846(BMP4)
CMY: 
ACS: 
PBI: 
XLA: 
397873(bmp2-b) 397874(bmp4-a) 399322(bmp4-b)
XTR: 
548717(bmp2) 549788(bmp4)
DRE: 
30612(bmp4) 30632(bmp2b)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
778554(bmp2/4)
SPU: 
373196(BMP2/4)
DME: 
DPO: 
Dpse_GA22099(Dpse_dpp)
DAN: 
DER: 
Dere_GG24858(Dere_dpp)
DPE: 
DSE: 
DSI: 
Dsim_GD23157(Dsim_dpp)
DWI: 
DYA: 
Dyak_GE18157(Dyak_dpp)
DGR: 
DMO: 
DVI: 
Dvir_GJ17292(Dvir_dpp)
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
727101(dpp)
NVI: 
TCA: 
654513(Dpp)
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG19011(Cbr-dbl-1)
BMY: 
LOA: 
HRO: 
LGI: 
NVE: 
TAD: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Schmierer B, Hill CS
  Title
TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility.
  Journal
Nat Rev Mol Cell Biol 8:970-82 (2007)
Reference
PMID:9759503
  Authors
Massague J.
  Title
TGF-beta signal transduction.
  Journal
Annu Rev Biochem 67:753-91 (1998)

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