KEGG   ORTHOLOGY: K04662Help
Entry
K04662                      KO                                     

Name
BMP2_4
Definition
bone morphogenetic protein 2/4
Pathway
MAPK signaling pathway - fly
Cytokine-cytokine receptor interaction
Hedgehog signaling pathway - fly
TGF-beta signaling pathway
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
Pathways in cancer
Basal cell carcinoma
Module
M00679  
BMP signaling
Disease
H00516  
Isolated orofacial clefts
H01027  
Anophthalmia and microphthalmia (A/M)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04013 MAPK signaling pathway - fly
    K04662  BMP2_4; bone morphogenetic protein 2/4
   04341 Hedgehog signaling pathway - Fly
    K04662  BMP2_4; bone morphogenetic protein 2/4
   04350 TGF-beta signaling pathway
    K04662  BMP2_4; bone morphogenetic protein 2/4
   04390 Hippo signaling pathway
    K04662  BMP2_4; bone morphogenetic protein 2/4
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04662  BMP2_4; bone morphogenetic protein 2/4
 Cellular Processes
  Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04662  BMP2_4; bone morphogenetic protein 2/4
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04662  BMP2_4; bone morphogenetic protein 2/4
   05217 Basal cell carcinoma
    K04662  BMP2_4; bone morphogenetic protein 2/4
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00679  BMP signaling
     K04662  BMP2_4; bone morphogenetic protein 2/4
Cytokines [BR:ko04052]
 TGF-beta family
  BMP2 subfamily
   K04662  BMP2_4; bone morphogenetic protein 2/4
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Morphogens
   K04662  BMP2_4; bone morphogenetic protein 2/4
BRITE hierarchy
Genes
HSA: 
650(BMP2) 652(BMP4)
PTR: 
107968170(BMP4) 452912(BMP4) 458090(BMP2)
PPS: 
100967346(BMP2) 100987443(BMP4)
GGO: 
PON: 
100449444(BMP4) 100460853(BMP2)
NLE: 
100586277(BMP4) 100586297(BMP2)
MCC: 
694618(BMP4) 718330(BMP2)
MCF: 
102132568(BMP4) 102145501(BMP2)
CSAB: 
103229007(BMP4) 103246725(BMP2)
RRO: 
104669157(BMP4) 104681477(BMP2)
CJC: 
100398270(BMP4) 100408260(BMP2)
SBQ: 
101038031(BMP4) 101050026(BMP2)
MMU: 
12156(Bmp2) 12159(Bmp4)
RNO: 
25296(Bmp4) 29373(Bmp2)
CGE: 
100752564(Bmp2) 100754303(Bmp4)
NGI: 
103725543(Bmp2) 103739231(Bmp4)
HGL: 
101711207(Bmp4) 101723419(Bmp2)
OCU: 
TUP: 
102469552(BMP2) 102497487(BMP4)
CFA: 
477162(BMP2) 490695(BMP4)
AML: 
100465860(BMP2) 100477715(BMP4)
UMR: 
103672975(BMP4) 103674423(BMP2)
FCA: 
100301987(BMP2) 101100311(BMP4)
PTG: 
102950088(BMP4) 102961685(BMP2)
BTA: 
407216(BMP4) 615037(BMP2)
BOM: 
102266106(BMP4) 102268860(BMP2)
PHD: 
CHX: 
100860789(BMP4) 100860831(BMP2)
OAS: 
101117688(BMP2) 443502(BMP4)
SSC: 
100113425(BMP4) 100152318(BMP2) 100157103(BMP2)
CFR: 
102509507(BMP4) 102514653(BMP2)
BACU: 
103004284(BMP2) 103010740(BMP4)
LVE: 
103070700(BMP2) 103072786(BMP4)
ECB: 
100034048(BMP4) 100051701(BMP2)
MYB: 
102241256(BMP2) 102262406(BMP4)
MYD: 
PALE: 
102881920(BMP4) 102886941(BMP2)
LAV: 
100654115(BMP4) 100654878(BMP2)
MDO: 
100010652(BMP4) 100031674(BMP2)
SHR: 
100916609(BMP4) 100935094(BMP2)
OAA: 
100084030(BMP2)
GGA: 
378779(BMP2) 396165(BMP4)
MGP: 
100544182(BMP4) 100549917(BMP2)
CJO: 
107310979(BMP2) 107315532(BMP4)
APLA: 
101803077(BMP4) 101805386(BMP2)
TGU: 
100218108(BMP2) 100221891(BMP4)
GFR: 
102037777(BMP2) 102044724(BMP4)
FAB: 
101816355(BMP2) 101816834(BMP4)
PHI: 
102101225(BMP2) 102110411(BMP4)
CCW: 
104687658(BMP4) 104691561(BMP2)
FPG: 
101922026(BMP2) 101923141(BMP4)
FCH: 
102047171(BMP4) 102048793(BMP2)
CLV: 
102083678(BMP2) 102098788(BMP4)
AAM: 
106490352(BMP2) 106494596(BMP4)
ASN: 
AMJ: 
102564323(BMP2) 102573848(BMP4)
PSS: 
102455280(BMP2) 102459846(BMP4)
CMY: 
102932745(BMP4) 102939464(BMP2)
ACS: 
PBI: 
103054912(BMP4) 103059412(BMP2)
GJA: 
XLA: 
397873(bmp2.L) 397874(bmp4.L) 399322(bmp4.S)
XTR: 
548717(bmp2) 549788(bmp4)
DRE: 
30612(bmp4) 30632(bmp2b)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
CMK: 
103175246(bmp4) 103186457(bmp2)
BFO: 
SPU: 
373196(BMP2/4)
SKO: 
DME: 
DPO: 
Dpse_GA22099(Dpse_dpp)
DAN: 
DER: 
Dere_GG24858(Dere_dpp)
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
Dyak_GE18157(Dyak_dpp)
DGR: 
DMO: 
DVI: 
Dvir_GJ17292(Dvir_dpp)
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
727101(dpp)
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
654513(Dpp)
BMOR: 
DPL: 
API: 
PHU: 
DPX: 
ISC: 
CEL: 
CBR: 
CBG19011(Cbr-dbl-1)
BMY: 
LOA: 
HRO: 
LGI: 
CRG: 
105333366(mgdf)
OBI: 
NVE: 
ADF: 
107334071(AdiBmp2/4) 107334704 107348831(AdiTgf2)
TAD: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Tanaka K, Kaji H, Yamaguchi T, Kanazawa I, Canaff L, Hendy GN, Sugimoto T
  Title
Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2alpha-ATF4 pathway in the commitment of myoblastic into osteoblastic cells.
  Journal
Calcif Tissue Int 94:454-64 (2014)
  Sequence
[mmu:12156]
Reference
  Authors
Hens JR, Dann P, Zhang JP, Harris S, Robinson GW, Wysolmerski J
  Title
BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.
  Journal
Development 134:1221-30 (2007)
  Sequence
[mmu:12159]

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