KEGG   ORTHOLOGY: K04675Help
Entry
K04675                      KO                                     

Name
ACVR1, ALK2
Definition
activin receptor type-1 [EC:2.7.11.30]
Pathway
ko04060  Cytokine-cytokine receptor interaction
ko04350  TGF-beta signaling pathway
ko04550  Signaling pathways regulating pluripotency of stem cells
ko05418  Fluid shear stress and atherosclerosis
Module
M00679  BMP signaling
Disease
H00430  Fibrodysplasia ossificans progressiva (FOP)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04350 TGF-beta signaling pathway
    K04675  ACVR1, ALK2; activin receptor type-1
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04675  ACVR1, ALK2; activin receptor type-1
 Cellular Processes
  Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04675  ACVR1, ALK2; activin receptor type-1
 Human Diseases
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04675  ACVR1, ALK2; activin receptor type-1
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00679  BMP signaling
     K04675  ACVR1, ALK2; activin receptor type-1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     K04675  ACVR1, ALK2; activin receptor type-1
Protein kinases [BR:ko01001]
 Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR1 family [OT]
   K04675  ACVR1, ALK2; activin receptor type-1
BRITE hierarchy
Other DBs
GO: 0016361
Genes
HSA: 90(ACVR1)
PTR: 470565(ACVR1)
PPS: 100967435(ACVR1)
GGO: 101124161(ACVR1)
PON: 100455728(ACVR1)
NLE: 100594249(ACVR1)
MCC: 697935(ACVR1)
MCF: 102134051(ACVR1)
CSAB: 103217143(ACVR1)
RRO: 104654252(ACVR1)
RBB: 108544116(ACVR1)
CJC: 100406595(ACVR1)
SBQ: 101051443(ACVR1)
MMU: 11477(Acvr1)
RNO: 79558(Acvr1)
CGE: 100758565(Acvr1)
NGI: 103741053(Acvr1)
HGL: 101711343(Acvr1)
CCAN: 109688929(Acvr1)
OCU: 100355119(ACVR1)
TUP: 102471973(ACVR1)
CFA: 478757(ACVR1)
AML: 100476325(ACVR1)
UMR: 103659482(ACVR1)
ORO: 101363476(ACVR1)
FCA: 101091298(ACVR1)
PTG: 102955784(ACVR1)
AJU: 106978932(ACVR1)
BTA: 338068(ACVR1)
BOM: 102275369(ACVR1)
BIU: 109567478(ACVR1)
PHD: 102325720(ACVR1)
CHX: 100860926(ACVR1)
OAS: 443161(ACVR1)
SSC: 100152307(ACVR1)
CFR: 102512007(ACVR1)
CDK: 105093706(ACVR1)
BACU: 102998999(ACVR1)
LVE: 103085459(ACVR1)
OOR: 101285877(ACVR1)
ECB: 100050899(ACVR1)
EPZ: 103554403(ACVR1)
EAI: 106842688(ACVR1)
MYB: 102263759(ACVR1)
MYD: 102767973(ACVR1)
HAI: 109379868(ACVR1)
RSS: 109445143(ACVR1)
PALE: 102880880(ACVR1)
LAV: 100666899(ACVR1)
TMU: 101357210
MDO: 100021438(ACVR1)
SHR: 100928279(ACVR1)
OAA: 100077006(ACVR1)
GGA: 395246(ATVR1)
MGP: 100546560(ACVR1)
CJO: 107316966(ACVR1)
APLA: 101793792(ACVR1)
ACYG: 106043900(ACVR1)
TGU: 100230545(ACVR1)
GFR: 102040859(ACVR1)
FAB: 101818057(ACVR1)
PHI: 102109524(ACVR1)
PMAJ: 107207654(ACVR1)
CCW: 104694116(ACVR1)
FPG: 101911977(ACVR1)
FCH: 102053092(ACVR1)
CLV: 102087076(ACVR1)
EGZ: 104126443(ACVR1)
AAM: 106486557(ACVR1)
ASN: 102378519(ACVR1) 102385749
AMJ: 102559894 102569539(ACVR1)
PSS: 102455326(ACVR1)
CMY: 102948189(ACVR1)
CPIC: 101937747(ACVR1)
ACS: 100552279(acvr1)
PVT: 110083054(ACVR1)
PBI: 103049229(ACVR1)
GJA: 107110765(ACVR1)
XLA: 108708536(acvrl1.L) 108708988(acvrl1.S) 399083(acvr1.S) 399103(acvr1.L)
XTR: 100493282(acvrl1) 550111(acvr1)
NPR: 108784364(ACVR1)
DRE: 30615(acvr1l)
IPU: 108266766(acvr1) 108267867 108275854(ACVR1)
TRU: 101064229 101072160(acvr1)
LCO: 104920073(acvr1) 104926585
NCC: 104954419(acvr1) 104965961
OLA: 101166428 101173900(acvr1)
CSEM: 103380097 103392173(acvr1)
HCQ: 109514817(acvr1) 109517367
BPEC: 110155079 110166565(acvr1)
SASA: 100196610(acvr1) 106572672 106574510 106581817(acvr1) 106586172(ACVR1)
ELS: 105019986 105022431(acvr1)
LCM: 102345137(ACVR1) 102356523 102363253(ACVRL1)
CIN: 778776(tgfbr-ia)
SPU: 590282
APLC: 110986020
SKO: 100370104
DME: Dmel_CG1891(sax)
DSI: Dsimw501_GD15359(Dsim_GD15359)
MDE: 101891682
AAG: 5566323
AME: 725711(sax)
BIM: 100742109
BTER: 100651383
SOC: 105193773
AEC: 105144103
ACEP: 105624537
PBAR: 105422399
HST: 105185256
CFO: 105249162
LHU: 105668812
PGC: 109861473
NVI: 100119760(Sax)
TCA: 658545(sax)
DPA: 109546901
NVL: 108566382
BMOR: 101738704
PMAC: 106716426
PRAP: 110996357
PXY: 105380967
API: 100169150
DNX: 107165106
ZNE: 110830842
FCD: 110858442
TUT: 107365252
CRG: 105345020
MYI: 110450755
OBI: 106874712
LAK: 106153366
SHX: MS3_04078
EPA: 110232278
HMG: 100210091
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8389764
  Authors
Matsuzaki K, Xu J, Wang F, McKeehan WL, Krummen L, Kan M
  Title
A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor.
  Journal
J Biol Chem 268:12719-23 (1993)
  Sequence
[hsa:90]

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