KEGG   ORTHOLOGY: K04685Help
Entry
K04685                      KO                                     

Name
CDKN2B, P15, INK4B
Definition
cyclin-dependent kinase inhibitor 2B
Pathway
ko04068  FoxO signaling pathway
ko04110  Cell cycle
ko04218  Cellular senescence
ko04350  TGF-beta signaling pathway
ko04934  Cushing's syndrome
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05222  Small cell lung cancer
ko05226  Gastric cancer
Disease
H00015  Malignant pleural mesothelioma
H00036  Osteosarcoma
H00409  Type II diabetes mellitus
H01463  Mycosis fungoides
H01556  Meningioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04350 TGF-beta signaling pathway
    K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
   04068 FoxO signaling pathway
    K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
   04218 Cellular senescence
    K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
   05203 Viral carcinogenesis
    K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
   05226 Gastric cancer
    K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
   05222 Small cell lung cancer
    K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
  Infectious diseases
   05166 HTLV-I infection
    K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
BRITE hierarchy
Other DBs
GO: 0004861
Genes
HSA: 1030(CDKN2B)
PTR: 473204(CDKN2B)
PPS: 100976219(CDKN2B)
GGO: 101146090(CDKN2B)
PON: 100459175(CDKN2B)
NLE: 100593298(CDKN2B)
MCC: 709209(CDKN2B)
MCF: 101866825(CDKN2B)
CSAB: 103219356(CDKN2B)
RRO: 104654271(CDKN2B)
RBB: 108537064(CDKN2B)
CJC: 100392363(CDKN2B)
SBQ: 101030939(CDKN2B)
MMU: 12579(Cdkn2b)
RNO: 25164(Cdkn2b)
NGI: 103730664(Cdkn2b)
HGL: 101701062
CCAN: 109701109
OCU: 100351874(CDKN2B)
TUP: 102495801 102500294(CDKN2B)
CFA: 481563(CDKN2B)
AML: 100473431(CDKN2B)
ORO: 101378797(CDKN2B)
FCA: 101087014(CDKN2B)
AJU: 106986385(CDKN2B)
BTA: 527124(CDKN2B)
BIU: 109562837(CDKN2B)
CHX: 102172895(CDKN2B)
OAS: 101107164(CDKN2B)
SSC: 397227(CDKN2B)
CFR: 102517211(CDKN2B)
CDK: 105092868(CDKN2B)
BACU: 103011925(CDKN2B)
LVE: 103089606(CDKN2B)
OOR: 101276528(CDKN2B) 105748701
ECB: 100034122(CDKN2B)
EPZ: 103543581(CDKN2B)
EAI: 106824765(CDKN2B)
MYB: 102260903(CDKN2B)
HAI: 109374676(CDKN2B)
RSS: 109436479
PALE: 102893142(CDKN2B)
LAV: 100664726(CDKN2B)
TMU: 101351137
MDO: 100021947(CDKN2B)
GGA: 395076(CDKN2B)
CJO: 107306707(CDKN2B)
TGU: 100218902
PMAJ: 107198353
ACS: 100562668(cdkn2b)
PBI: 103066227(CDKN2B) 103066473
XLA: 108706939(cdkn2b.S) 779240(cdkn2b.L)
XTR: 448767(cdkn2b)
NPR: 108801558
CCAR: 109098476
IPU: 108263810
AMEX: 111189396
TRU: 101062640(cdkn2A/B)
LCO: 104926969
NCC: 104965090
MZE: 101471656
OLA: 110014168(cdkn2b)
XMA: 102224758(cdkn2b)
PRET: 103466455(cdkn2b)
NFU: 107375282(cdkn2b)
CSEM: 103383534
LCF: 108896541
HCQ: 109511366
SASA: 100196147(cdn2b) 106610370(CDN2B)
ELS: 105021059
LCM: 102356560(CDKN2B)
CMK: 103182848(p16INK4a)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Canepa ET, Scassa ME, Ceruti JM, Marazita MC, Carcagno AL, Sirkin PF, Ogara MF
  Title
INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions.
  Journal
IUBMB Life 59:419-26 (2007)
DOI:10.1080/15216540701488358
Reference
PMID:8078588
  Authors
Hannon GJ, Beach D
  Title
p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.
  Journal
Nature 371:257-61 (1994)
DOI:10.1038/371257a0
  Sequence
[hsa:1030]

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