KEGG   ORTHOLOGY: K04694Help
Entry
K04694                      KO                                     

Name
SOCS1, JAB
Definition
suppressor of cytokine signaling 1
Pathway
Ubiquitin mediated proteolysis
Osteoclast differentiation
Jak-STAT signaling pathway
Insulin signaling pathway
Prolactin signaling pathway
Type II diabetes mellitus
Toxoplasmosis
MicroRNAs in cancer
Module
M00388  
ECS complex
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04694  SOCS1, JAB; suppressor of cytokine signaling 1
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K04694  SOCS1, JAB; suppressor of cytokine signaling 1
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K04694  SOCS1, JAB; suppressor of cytokine signaling 1
   04917 Prolactin signaling pathway
    K04694  SOCS1, JAB; suppressor of cytokine signaling 1
  Development
   04380 Osteoclast differentiation
    K04694  SOCS1, JAB; suppressor of cytokine signaling 1
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    K04694  SOCS1, JAB; suppressor of cytokine signaling 1
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K04694  SOCS1, JAB; suppressor of cytokine signaling 1
  Infectious diseases
   05145 Toxoplasmosis
    K04694  SOCS1, JAB; suppressor of cytokine signaling 1
KEGG modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00388  ECS complex
     K04694  SOCS1, JAB; suppressor of cytokine signaling 1
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  multi subunit Ring-finger type E3
   ECS complex
    target recognizing subunit (SOCS box)
     K04694  SOCS1, JAB; suppressor of cytokine signaling 1
BRITE hierarchy
Genes
HSA: 
8651(SOCS1)
PTR: 
737070(SOCS1)
GGO: 
101131805(SOCS1)
PON: 
100445635(SOCS1)
NLE: 
100589181(SOCS1)
MCC: 
711180(SOCS1)
MCF: 
102135411(SOCS1)
CJC: 
100402275(SOCS1)
MMU: 
12703(Socs1)
RNO: 
252971(Socs1)
CGE: 
NGI: 
103731577(Socs1)
HGL: 
OCU: 
100339386(SOCS1)
TUP: 
102495553(SOCS1)
CFA: 
490006(SOCS1)
AML: 
BTA: 
518795(SOCS1)
OAS: 
101107324(SOCS1)
SSC: 
100307052(SOCS1)
BACU: 
103000775(SOCS1)
LVE: 
103089381(SOCS1)
ECB: 
102148488(SOCS1)
MYB: 
102248245(SOCS1)
MYD: 
102772456(SOCS1)
PALE: 
102878735(SOCS1)
MDO: 
100025389(SOCS1)
SHR: 
OAA: 
GGA: 
416630(SOCS1)
MGP: 
APLA: 
101801940(SOCS1)
TGU: 
100228306(SOCS1)
FAB: 
101818258(SOCS1)
PHI: 
102099147(SOCS1)
FPG: 
101912887(SOCS1)
FCH: 
CLV: 
102092369(SOCS1)
ASN: 
AMJ: 
PSS: 
CMY: 
102932360(SOCS1)
ACS: 
100560891(socs1)
PBI: 
103067787(SOCS1)
XLA: 
100294520(socs1-b) 443921(socs1-a)
XTR: 
496789(socs1)
DRE: 
445073(socs1a)
TRU: 
100049621(socs1)
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ.
  Title
The SOCS box: a tale of destruction and degradation.
  Journal
Trends Biochem Sci 27:235-41 (2002)
  Sequence
[hsa:8651]
Reference
  Authors
Rui L, Yuan M, Frantz D, Shoelson S, White MF.
  Title
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2.
  Journal
J Biol Chem 277:42394-8 (2002)
  Sequence
[hsa:8651] [mmu:12703]
Reference
  Authors
Kamizono S, Hanada T, Yasukawa H, Minoguchi S, Kato R, Minoguchi M, Hattori K, Hatakeyama S, Yada M, Morita S, Kitamura T, Kato H, Nakayama Ki, Yoshimura A
  Title
The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.
  Journal
J Biol Chem 276:12530-8 (2001)
  Sequence
[hsa:8651]

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