KEGG   ORTHOLOGY: K04695Help
Entry
K04695                      KO                                     
Name
SOCS2, CIS2
Definition
suppressor of cytokine signaling 2
Pathway
Jak-STAT signaling pathway
Insulin signaling pathway
Prolactin signaling pathway
Type II diabetes mellitus
Module
M00388  
ECS complex
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
   04917 Prolactin signaling pathway
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
KEGG modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00388  ECS complex
     K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  multi subunit Ring-finger type E3
   ECS complex
    target recognizing subunit (SOCS box)
     K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
BRITE hierarchy
Genes
HSA: 
8835(SOCS2)
PTR: 
452127(SOCS2)
PPS: 
GGO: 
101141962(SOCS2)
PON: 
100440378(SOCS2)
MCC: 
715772(SOCS2)
MCF: 
102125352(SOCS2)
MMU: 
216233(Socs2)
RNO: 
84607(Socs2)
HGL: 
TUP: 
102480737(SOCS2)
CFA: 
100855737(SOCS2)
AML: 
100474808
FCA: 
101080980(SOCS2)
PTG: 
102953997(SOCS2)
BTA: 
338437(SOCS2)
BOM: 
102268022(SOCS2)
PHD: 
102315362(SOCS2)
CHX: 
102178979(SOCS2)
SSC: 
100037966(SOCS2)
CFR: 
102505948(SOCS2)
BACU: 
103008379 103018227(SOCS2)
LVE: 
103070250(SOCS2)
ECB: 
100051952(SOCS2)
MYB: 
102260836(SOCS2)
MYD: 
102764738(SOCS2)
PALE: 
102889529(SOCS2)
MDO: 
100011895(SOCS2)
SHR: 
100925364(SOCS2)
OAA: 
100079417(SOCS2)
GGA: 
395219(SOCS2)
MGP: 
100544272
TGU: 
100229201(SOCS2)
FAB: 
101816040(SOCS2)
PHI: 
102114276(SOCS2)
APLA: 
101790013(SOCS2)
FPG: 
101915704(SOCS2)
FCH: 
102047256(SOCS2)
CLV: 
102097346(SOCS2)
ASN: 
102388356(SOCS2)
AMJ: 
102574136(SOCS2)
PSS: 
102447309 102453265(SOCS2)
CMY: 
102945521(SOCS2) 102945560
ACS: 
100552196
PBI: 
103051048(SOCS2)
XLA: 
734276(socs2)
XTR: 
100151723(socs2)
DRE: 
562062(socs2)
TRU: 
100144308(socs2)
MZE: 
101485857
OLA: 
101164124
XMA: 
102234649
LCM: 
102356616(SOCS2) 102362993
CMK: 
103188876(socs2)
BFO: 
BRAFLDRAFT_216183 BRAFLDRAFT_61258
SPU: 
594503
BMOR: 
100862764(SOCS2-12)
ISC: 
IscW_ISCW015921
NVE: 
NEMVE_v1g93849
AQU: 
100638220
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ.
  Title
The SOCS box: a tale of destruction and degradation.
  Journal
Trends Biochem Sci 27:235-41 (2002)
Reference
  Authors
Iglesias-Gato D, Chuan YC, Wikstrom P, Augsten S, Jiang N, Niu Y, Seipel A, Danneman D, Vermeij M, Fernandez-Perez L, Jenster G, Egevad L, Norstedt G, Flores-Morales A
  Title
SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer.
  Journal
Carcinogenesis 35:24-33 (2014)
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