KEGG   ORTHOLOGY: K04695Help
Entry
K04695                      KO                                     

Name
SOCS2, CIS2
Definition
suppressor of cytokine signaling 2
Pathway
ko04630  Jak-STAT signaling pathway
ko04910  Insulin signaling pathway
ko04917  Prolactin signaling pathway
ko04930  Type II diabetes mellitus
Module
M00388  ECS complex
M00684  JAK-STAT signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
   04917 Prolactin signaling pathway
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
KEGG modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00388  ECS complex
     K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
 Functional set
  Cellular processes
   Cell signaling
    M00684  JAK-STAT signaling
     K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   ECS complex
    Target recognizing subunit (SOCS box)
     K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
BRITE hierarchy
Genes
HSA: 8835(SOCS2)
PTR: 452127(SOCS2)
PPS: 100989242(SOCS2)
GGO: 101141962(SOCS2)
PON: 100440378(SOCS2)
NLE: 100604289(SOCS2)
MCC: 715772(SOCS2)
MCF: 102125352(SOCS2)
CSAB: 103238870(SOCS2)
RRO: 104678596(SOCS2)
RBB: 108527232(SOCS2)
CJC: 100396208(SOCS2)
SBQ: 101040467(SOCS2)
MMU: 216233(Socs2)
RNO: 84607(Socs2)
NGI: 103726290(Socs2)
HGL: 101716580(Socs2)
CCAN: 109688786(Socs2)
OCU: 100354019(SOCS2)
TUP: 102480737(SOCS2)
CFA: 100855737(SOCS2)
AML: 100474808(SOCS2)
UMR: 103660099(SOCS2)
ORO: 101373719(SOCS2)
FCA: 101080980(SOCS2)
PTG: 102953997(SOCS2)
AJU: 106973415(SOCS2)
BTA: 338437(SOCS2)
BOM: 102268022(SOCS2)
BIU: 109558981(SOCS2)
PHD: 102315362(SOCS2)
CHX: 102178979(SOCS2)
OAS: 101115017(SOCS2)
SSC: 100037966(SOCS2)
CFR: 102505948(SOCS2)
CDK: 105097413(SOCS2)
BACU: 103008379 103018227(SOCS2)
LVE: 103070250(SOCS2)
OOR: 101289153(SOCS2)
ECB: 100051952(SOCS2)
EPZ: 103564583(SOCS2)
EAI: 106831177(SOCS2)
MYB: 102260836(SOCS2)
MYD: 102764738(SOCS2)
HAI: 109392673(SOCS2)
RSS: 109433793(SOCS2)
PALE: 102889529(SOCS2)
LAV: 100660067(SOCS2)
TMU: 101349221
MDO: 100011895(SOCS2)
SHR: 100925364(SOCS2)
OAA: 100079417(SOCS2)
GGA: 395219(SOCS2)
MGP: 100544272(SOCS2)
CJO: 107311591(SOCS2)
APLA: 101790013(SOCS2)
ACYG: 106036904(SOCS2)
TGU: 100229201(SOCS2)
GFR: 102031776(SOCS2)
FAB: 101816040(SOCS2)
PHI: 102114276(SOCS2)
PMAJ: 107204420(SOCS2)
CCW: 104696565(SOCS2)
FPG: 106112815(SOCS2)
FCH: 106631601(SOCS2)
CLV: 102097346(SOCS2)
EGZ: 104132329(SOCS2)
AAM: 106488466(SOCS2)
ASN: 102388356(SOCS2)
AMJ: 102574136(SOCS2)
PSS: 102447309 102453265(SOCS2)
CMY: 102945521(SOCS2) 102945560
CPIC: 101933959 101943086(SOCS2)
ACS: 100552196(socs2)
PVT: 110091701(SOCS2)
PBI: 103051048(SOCS2)
GJA: 107118612(SOCS2)
XLA: 108711062(socs2.L) 734276(socs2.S)
XTR: 100151723(socs2)
NPR: 108790061(SOCS2)
DRE: 562062(socs2)
IPU: 108276077
AMEX: 103034993(socs2)
TRU: 100144308(socs2)
LCO: 104938686(socs2)
NCC: 104961843(socs2)
MZE: 101485857
OLA: 101164124
XMA: 102234649
PRET: 103459817
NFU: 107387837(socs2)
CSEM: 103382466
LCF: 108890543
BPEC: 110161754
SASA: 106567289 106576177(SOCS2a) 106609294(SOCS2b)
ELS: 105027835(socs2)
SFM: 108920753(socs2) 108939161
LCM: 102356616(SOCS2) 102362993
CMK: 103188876(socs2)
SPU: 594503
APLC: 110986036
BMOR: 100862764(SOCS2-12)
PMAC: 106718237
PRAP: 110998970
PXY: 105385539
CRG: 105334011
OBI: 106872107
LAK: 106154562
EPA: 110244417
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ.
  Title
The SOCS box: a tale of destruction and degradation.
  Journal
Trends Biochem Sci 27:235-41 (2002)
DOI:10.1016/S0968-0004(02)02085-6
  Sequence
[hsa:8835]
Reference
  Authors
Iglesias-Gato D, Chuan YC, Wikstrom P, Augsten S, Jiang N, Niu Y, Seipel A, Danneman D, Vermeij M, Fernandez-Perez L, Jenster G, Egevad L, Norstedt G, Flores-Morales A
  Title
SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer.
  Journal
Carcinogenesis 35:24-33 (2014)
DOI:10.1093/carcin/bgt304
  Sequence
[hsa:8835]

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