KEGG   ORTHOLOGY: K04695Help
Entry
K04695                      KO                                     
Name
SOCS2, CIS2
Definition
suppressor of cytokine signaling 2
Pathway
Jak-STAT signaling pathway
Insulin signaling pathway
Prolactin signaling pathway
Type II diabetes mellitus
Module
M00388  
ECS complex
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
   04917 Prolactin signaling pathway
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
KEGG pathway modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00388  ECS complex [BR:ko04121]
     K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  multi subunit Ring-finger type E3
   ECS complex
    target recognizing subunit (SOCS box)
     K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
BRITE hierarchy
Genes
HSA: 
8835(SOCS2)
PTR: 
452127(SOCS2)
PPS: 
100989242(SOCS2)
GGO: 
101141962(SOCS2)
PON: 
100440378(SOCS2)
MCC: 
715772(SOCS2)
MMU: 
216233(Socs2)
RNO: 
84607(Socs2)
CGE: 
HGL: 
CFA: 
100855737(SOCS2)
AML: 
100474808
FCA: 
101080980(SOCS2)
BTA: 
338437(SOCS2)
SSC: 
100037966(SOCS2)
ECB: 
100051952(SOCS2)
MDO: 
100011895
SHR: 
100925364(SOCS2)
OAA: 
100079417
GGA: 
395219(SOCS2)
MGP: 
100544272
TGU: 
100229201(SOCS2)
FAB: 
101816040(SOCS2)
APLA: 
101790013(SOCS2)
FPG: 
101915704(SOCS2)
ACS: 
100552196
XLA: 
734276(socs2)
XTR: 
100151723(socs2)
DRE: 
562062(socs2)
TRU: 
100144308(socs2)
MZE: 
101485857
OLA: 
101164124
BFO: 
BRAFLDRAFT_216183 BRAFLDRAFT_61258
SPU: 
594503
BMOR: 
100862764(SOCS2-12)
ISC: 
IscW_ISCW015921
NVE: 
NEMVE_v1g93849
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ.
  Title
The SOCS box: a tale of destruction and degradation.
  Journal
Trends Biochem Sci 27:235-41 (2002)
Reference
  Authors
Piessevaux J, Lavens D, Peelman F, Tavernier J
  Title
The many faces of the SOCS box.
  Journal
Cytokine Growth Factor Rev 19:371-81 (2008)
Reference
  Authors
Croker BA, Kiu H, Nicholson SE
  Title
SOCS regulation of the JAK/STAT signalling pathway.
  Journal
Semin Cell Dev Biol 19:414-22 (2008)
Reference
  Authors
Bullock AN, Debreczeni JE, Edwards AM, Sundstrom M, Knapp S
  Title
Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase.
  Journal
Proc Natl Acad Sci U S A 103:7637-42 (2006)
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