KEGG   ORTHOLOGY: K04695Help
Entry
K04695                      KO                                     

Name
SOCS2, CIS2
Definition
suppressor of cytokine signaling 2
Pathway
ko04630  Jak-STAT signaling pathway
ko04910  Insulin signaling pathway
ko04917  Prolactin signaling pathway
ko04930  Type II diabetes mellitus
Module
M00388  ECS complex
M00684  JAK-STAT signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
   04917 Prolactin signaling pathway
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
KEGG modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00388  ECS complex
     K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
 Functional set
  Cellular processes
   Cell signaling
    M00684  JAK-STAT signaling
     K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   ECS complex
    Target recognizing subunit (SOCS box)
     K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
BRITE hierarchy
Genes
HSA: 8835(SOCS2)
PTR: 452127(SOCS2)
PPS: 100989242(SOCS2)
GGO: 101141962(SOCS2)
PON: 100440378(SOCS2)
NLE: 100604289(SOCS2)
MCC: 715772(SOCS2)
MCF: 102125352(SOCS2)
CSAB: 103238870(SOCS2)
RRO: 104678596(SOCS2)
RBB: 108527232(SOCS2)
CJC: 100396208(SOCS2)
SBQ: 101040467(SOCS2)
MMU: 216233(Socs2)
RNO: 84607(Socs2)
NGI: 103726290(Socs2)
HGL: 101716580(Socs2)
CCAN: 109688786(Socs2)
OCU: 100354019(SOCS2)
TUP: 102480737(SOCS2)
CFA: 100855737(SOCS2)
AML: 100474808(SOCS2)
UMR: 103660099(SOCS2)
ORO: 101373719(SOCS2)
FCA: 101080980(SOCS2)
PTG: 102953997(SOCS2)
AJU: 106973415(SOCS2)
BTA: 338437(SOCS2)
BOM: 102268022(SOCS2)
BIU: 109558981(SOCS2)
PHD: 102315362(SOCS2)
CHX: 102178979(SOCS2)
OAS: 101115017(SOCS2)
SSC: 100037966(SOCS2)
CFR: 102505948(SOCS2)
CDK: 105097413(SOCS2)
BACU: 103008379 103018227(SOCS2)
LVE: 103070250(SOCS2)
OOR: 101289153(SOCS2)
ECB: 100051952(SOCS2)
EPZ: 103564583(SOCS2)
EAI: 106831177(SOCS2)
MYB: 102260836(SOCS2)
MYD: 102764738(SOCS2)
HAI: 109392673(SOCS2)
RSS: 109433793(SOCS2)
PALE: 102889529(SOCS2)
LAV: 100660067(SOCS2)
TMU: 101349221
MDO: 100011895(SOCS2)
SHR: 100925364(SOCS2)
OAA: 100079417(SOCS2)
GGA: 395219(SOCS2)
MGP: 100544272(SOCS2)
CJO: 107311591(SOCS2)
APLA: 101790013(SOCS2)
ACYG: 106036904(SOCS2)
TGU: 100229201(SOCS2)
GFR: 102031776(SOCS2)
FAB: 101816040(SOCS2)
PHI: 102114276(SOCS2)
PMAJ: 107204420(SOCS2)
CCW: 104696565(SOCS2)
FPG: 106112815(SOCS2)
FCH: 106631601(SOCS2)
CLV: 102097346(SOCS2)
EGZ: 104132329(SOCS2)
AAM: 106488466(SOCS2)
ASN: 102388356(SOCS2)
AMJ: 102574136(SOCS2)
PSS: 102447309 102453265(SOCS2)
CMY: 102945521(SOCS2) 102945560
CPIC: 101933959 101943086(SOCS2)
ACS: 100552196(socs2)
PVT: 110091701(SOCS2)
PBI: 103051048(SOCS2)
GJA: 107118612(SOCS2)
XLA: 108711062(socs2.L) 734276(socs2.S)
XTR: 100151723(socs2)
NPR: 108790061(SOCS2)
DRE: 562062(socs2)
SRX: 107725676 107732999
SANH: 107664864 107695891
SGH: 107553891 107590271
CCAR: 109067056 109088139
IPU: 108276077
AMEX: 103034993(socs2)
TRU: 100144308(socs2)
TNG: GSTEN00011568G001
LCO: 104938686(socs2)
NCC: 104961843(socs2)
MZE: 101485857
OLA: 101164124
XMA: 102234649
PRET: 103459817
NFU: 107387837(socs2)
CSEM: 103382466
LCF: 108890543
BPEC: 110161754
SASA: 106567289 106576177(SOCS2a) 106609294(SOCS2b)
ELS: 105027835(socs2)
SFM: 108920753(socs2) 108939161
LCM: 102356616(SOCS2) 102362993
CMK: 103188876(socs2)
BFO: BRAFLDRAFT_216183 BRAFLDRAFT_61258
SPU: 594503
APLC: 110986036
BMOR: 100862764(SOCS2-12)
DPL: KGM_200332
PMAC: 106718237
PRAP: 110998970
PXY: 105385539
DPX: DAPPUDRAFT_26988
ISC: IscW_ISCW015921
CRG: 105334011
OBI: 106872107
LAK: 106154562
NVE: NEMVE_v1g93849
EPA: 110244417
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ.
  Title
The SOCS box: a tale of destruction and degradation.
  Journal
Trends Biochem Sci 27:235-41 (2002)
DOI:10.1016/S0968-0004(02)02085-6
  Sequence
[hsa:8835]
Reference
  Authors
Iglesias-Gato D, Chuan YC, Wikstrom P, Augsten S, Jiang N, Niu Y, Seipel A, Danneman D, Vermeij M, Fernandez-Perez L, Jenster G, Egevad L, Norstedt G, Flores-Morales A
  Title
SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer.
  Journal
Carcinogenesis 35:24-33 (2014)
DOI:10.1093/carcin/bgt304
  Sequence
[hsa:8835]

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (10)   
   KEGG PATHWAY (8)   
   KEGG MODULE (2)   
Gene (621)   
   KEGG GENES (133)   
   KEGG MGENES (9)   
   RefGene (470)   
   EGENES (7)   
   OC (2)   
Protein sequence (60)   
   UniProt (55)   
   SWISS-PROT (5)   
Literature (2)   
   PubMed (2)   
All databases (697)   

Download RDF
DBGET integrated database retrieval system