KEGG   ORTHOLOGY: K04696Help
Entry
K04696                      KO                                     
Name
SOCS3, CIS3
Definition
suppressor of cytokine signaling 3
Pathway
Ubiquitin mediated proteolysis
Osteoclast differentiation
Jak-STAT signaling pathway
TNF signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Hepatitis C
Influenza A
Herpes simplex infection
Module
M00388  
ECS complex
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   04668 TNF signaling pathway
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   04920 Adipocytokine signaling pathway
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
  Development
   04380 Osteoclast differentiation
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
  Infectious diseases
   05164 Influenza A
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   05160 Hepatitis C
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   05168 Herpes simplex infection
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
KEGG pathway modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00388  ECS complex [BR:ko04121]
     K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  multi subunit Ring-finger type E3
   ECS complex
    target recognizing subunit (SOCS box)
     K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
BRITE hierarchy
Genes
HSA: 
9021(SOCS3)
PTR: 
454921(SOCS3)
PPS: 
100978589(SOCS3)
GGO: 
101123839(SOCS3)
PON: 
100446544(SOCS3)
MCC: 
715680(SOCS3)
MMU: 
12702(Socs3)
RNO: 
89829(Socs3)
CFA: 
442949(SOCS3)
AML: 
FCA: 
101081846(SOCS3)
BTA: 
282081(SOCS3)
SSC: 
493186(SOCS3)
ECB: 
100050730(SOCS3)
MDO: 
100026656
SHR: 
100934360(SOCS3)
OAA: 
100090302
GGA: 
395299(SOCS3)
MGP: 
100547594
TGU: 
100227853(SOCS3)
ACS: 
100564374
XLA: 
380467(socs3)
XTR: 
448204(socs3)
DRE: 
406596(socs3b)
TRU: 
778006(socs-3)
OLA: 
101170518(socs3)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ.
  Title
The SOCS box: a tale of destruction and degradation.
  Journal
Trends Biochem Sci 27:235-41 (2002)
Reference
  Authors
Piessevaux J, Lavens D, Peelman F, Tavernier J
  Title
The many faces of the SOCS box.
  Journal
Cytokine Growth Factor Rev 19:371-81 (2008)
Reference
  Authors
Kamura T, Maenaka K, Kotoshiba S, Matsumoto M, Kohda D, Conaway RC, Conaway JW, Nakayama KI.
  Title
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.
  Journal
Genes Dev 18:3055-65 (2004)
Reference
  Authors
Li Y, McClintick J, Zhong L, Edenberg HJ, Yoder MC, Chan RJ
  Title
Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4.
  Journal
Blood 105:635-7 (2005)
Reference
  Authors
Yarwood SJ, Borland G, Sands WA, Palmer TM
  Title
Identification of CCAAT/enhancer-binding proteins as exchange protein activated by cAMP-activated transcription factors that mediate the induction of the SOCS-3  gene.
  Journal
J Biol Chem 283:6843-53 (2008)
Reference
  Authors
Rui L, Yuan M, Frantz D, Shoelson S, White MF.
  Title
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2.
  Journal
J Biol Chem 277:42394-8 (2002)
Reference
  Authors
Croker BA, Kiu H, Nicholson SE
  Title
SOCS regulation of the JAK/STAT signalling pathway.
  Journal
Semin Cell Dev Biol 19:414-22 (2008)
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