KEGG   ORTHOLOGY: K04696Help
Entry
K04696                      KO                                     

Name
SOCS3, CIS3
Definition
suppressor of cytokine signaling 3
Pathway
ko04120  Ubiquitin mediated proteolysis
ko04380  Osteoclast differentiation
ko04630  Jak-STAT signaling pathway
ko04668  TNF signaling pathway
ko04910  Insulin signaling pathway
ko04917  Prolactin signaling pathway
ko04920  Adipocytokine signaling pathway
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko05160  Hepatitis C
ko05164  Influenza A
ko05168  Herpes simplex infection
Module
M00388  ECS complex
M00684  JAK-STAT signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   04668 TNF signaling pathway
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   04920 Adipocytokine signaling pathway
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   04917 Prolactin signaling pathway
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
  Development
   04380 Osteoclast differentiation
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   04931 Insulin resistance
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
  Infectious diseases
   05164 Influenza A
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   05160 Hepatitis C
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   05168 Herpes simplex infection
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
KEGG modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00388  ECS complex
     K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
 Functional set
  Cellular processes
   Cell signaling
    M00684  JAK-STAT signaling
     K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   ECS complex
    Target recognizing subunit (SOCS box)
     K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
BRITE hierarchy
Genes
HSA: 9021(SOCS3)
PTR: 454921(SOCS3)
PPS: 100978589(SOCS3)
GGO: 101123839(SOCS3)
PON: 100446544(SOCS3)
MCC: 715680(SOCS3)
MCF: 102121569(SOCS3)
CSAB: 103243658(SOCS3)
RRO: 104677022(SOCS3)
RBB: 108517203(SOCS3)
CJC: 100398838(SOCS3)
SBQ: 101046533(SOCS3)
MMU: 12702(Socs3)
RNO: 89829(Socs3)
CGE: 100769267(Socs3)
NGI: 103747288(Socs3)
HGL: 101704157(Socs3)
CCAN: 109683139(Socs3)
OCU: 103346588(SOCS3)
TUP: 102486692(SOCS3)
CFA: 442949(SOCS3)
AML: 100475555(SOCS3)
UMR: 103665967(SOCS3)
ORO: 101364487(SOCS3)
FCA: 101081846(SOCS3)
BTA: 282081(SOCS3)
BOM: 102273017(SOCS3)
BIU: 109574319(SOCS3)
PHD: 102315804(SOCS3)
CHX: 102187711(SOCS3)
OAS: 100294595(SOCS3)
SSC: 493186(SOCS3)
CFR: 102518913(SOCS3)
CDK: 105092151(SOCS3)
BACU: 103013097(SOCS3)
LVE: 103071774(SOCS3)
OOR: 101284843(SOCS3)
ECB: 100050730(SOCS3)
EPZ: 103554055(SOCS3)
EAI: 106845267(SOCS3)
MYB: 102252296(SOCS3)
MYD: 102763837(SOCS3)
HAI: 109383617(SOCS3)
RSS: 109449408(SOCS3)
PALE: 102887834(SOCS3)
LAV: 100670741(SOCS3)
TMU: 101348420
MDO: 100026656(SOCS3)
SHR: 100934360(SOCS3)
OAA: 100090302(SOCS3)
GGA: 395299(SOCS3)
MGP: 100547594(SOCS3)
CJO: 107322171(SOCS3)
APLA: 101791200(SOCS3)
ACYG: 106046730(SOCS3)
TGU: 100227853(SOCS3)
GFR: 102044994(SOCS3)
FAB: 101810199(SOCS3)
PHI: 102107383(SOCS3)
PMAJ: 107212347(SOCS3)
FPG: 101912299(SOCS3)
FCH: 102058593(SOCS3)
CLV: 102085285(SOCS3)
AAM: 106487124(SOCS3)
ASN: 102386715(SOCS3)
AMJ: 102568555(SOCS3) 102570761
PSS: 102446993(SOCS3)
CMY: 102930798(SOCS3)
CPIC: 101947835 101953847(SOCS3)
ACS: 100560082 100564374(socs3)
PVT: 110078594 110090429(SOCS3)
PBI: 103057222 103064119(SOCS3)
GJA: 107113150 107115315(SOCS3)
XLA: 100158303 108696746 380467(socs3.S) 414533(socs3.L)
XTR: 394588(socs3) 448204(socs3)
NPR: 108801343 108801441(SOCS3)
DRE: 406596(socs3b)
IPU: 100528984(socs3) 108274104
TRU: 101079037 778006(socs3)
MZE: 101468895(socs3) 101479458
OLA: 101170518(socs3) 101170961(socs3)
PRET: 103461355 103481519(socs3)
NFU: 107387732(socs3)
CSEM: 103381769 103392817(socs3)
LCF: 108876107 108902726(socs3)
HCQ: 109519371(socs3) 109527547
ELS: 105013055(socs3) 105021322
SFM: 108922562 108924821(socs3)
LCM: 102346594(SOCS3) 102360670
CMK: 103175554(socs3)
ADF: 107353946
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ.
  Title
The SOCS box: a tale of destruction and degradation.
  Journal
Trends Biochem Sci 27:235-41 (2002)
DOI:10.1016/S0968-0004(02)02085-6
  Sequence
[hsa:9021]
Reference
  Authors
Kamura T, Maenaka K, Kotoshiba S, Matsumoto M, Kohda D, Conaway RC, Conaway JW, Nakayama KI.
  Title
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.
  Journal
Genes Dev 18:3055-65 (2004)
DOI:10.1101/gad.1252404
  Sequence
[hsa:9021]
Reference
  Authors
Rui L, Yuan M, Frantz D, Shoelson S, White MF.
  Title
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2.
  Journal
J Biol Chem 277:42394-8 (2002)
DOI:10.1074/jbc.C200444200
  Sequence
[hsa:9021] [mmu:12702]

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