KEGG   ORTHOLOGY: K04696Help
Entry
K04696                      KO                                     

Name
SOCS3, CIS3
Definition
suppressor of cytokine signaling 3
Pathway
Ubiquitin mediated proteolysis
Osteoclast differentiation
Jak-STAT signaling pathway
TNF signaling pathway
Insulin signaling pathway
Prolactin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
Influenza A
Herpes simplex infection
Module
M00388  
ECS complex
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   04668 TNF signaling pathway
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   04920 Adipocytokine signaling pathway
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   04917 Prolactin signaling pathway
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
  Development
   04380 Osteoclast differentiation
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
  Infectious diseases
   05164 Influenza A
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   05160 Hepatitis C
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   05168 Herpes simplex infection
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
KEGG modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00388  ECS complex
     K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  multi subunit Ring-finger type E3
   ECS complex
    target recognizing subunit (SOCS box)
     K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
BRITE hierarchy
Genes
HSA: 
9021(SOCS3)
PTR: 
454921(SOCS3)
PPS: 
100978589(SOCS3)
GGO: 
101123839(SOCS3)
PON: 
100446544(SOCS3)
MCC: 
715680(SOCS3)
MCF: 
102121569(SOCS3)
MMU: 
12702(Socs3)
RNO: 
89829(Socs3)
CGE: 
HGL: 
101704157(Socs3)
TUP: 
102486692(SOCS3)
CFA: 
442949(SOCS3)
AML: 
FCA: 
101081846(SOCS3)
BTA: 
282081(SOCS3)
BOM: 
102273017(SOCS3)
PHD: 
102315804(SOCS3)
CHX: 
102187711(SOCS3)
SSC: 
493186(SOCS3)
CFR: 
ECB: 
100050730(SOCS3)
MYB: 
102252296(SOCS3)
MYD: 
102763837(SOCS3)
PALE: 
102887834(SOCS3)
MDO: 
100026656(SOCS3)
SHR: 
100934360(SOCS3)
OAA: 
100090302(SOCS3)
GGA: 
395299(SOCS3)
MGP: 
TGU: 
100227853(SOCS3)
FAB: 
101810199(SOCS3)
PHI: 
102107383(SOCS3)
APLA: 
101791200(SOCS3)
FPG: 
101912299(SOCS3)
FCH: 
102058593(SOCS3)
CLV: 
102085285(SOCS3)
ASN: 
102386715(SOCS3)
PSS: 
102446993(SOCS3)
CMY: 
102930798(SOCS3)
ACS: 
XLA: 
380467(socs3) 414533(socs3)
XTR: 
448204(socs3)
DRE: 
406596(socs3b)
TRU: 
MZE: 
OLA: 
101170518(socs3) 101170961(socs3)
XMA: 
LCM: 
BFO: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ.
  Title
The SOCS box: a tale of destruction and degradation.
  Journal
Trends Biochem Sci 27:235-41 (2002)
Reference
  Authors
Kamura T, Maenaka K, Kotoshiba S, Matsumoto M, Kohda D, Conaway RC, Conaway JW, Nakayama KI.
  Title
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.
  Journal
Genes Dev 18:3055-65 (2004)
Reference
  Authors
Rui L, Yuan M, Frantz D, Shoelson S, White MF.
  Title
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2.
  Journal
J Biol Chem 277:42394-8 (2002)

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