KEGG   ORTHOLOGY: K04697Help
Entry
K04697                      KO                                     

Name
SOCS4
Definition
suppressor of cytokine signaling 4
Pathway
Jak-STAT signaling pathway
Insulin signaling pathway
Prolactin signaling pathway
Type II diabetes mellitus
Module
M00388  
ECS complex
M00684  
JAK-STAT signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K04697  SOCS4; suppressor of cytokine signaling 4
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K04697  SOCS4; suppressor of cytokine signaling 4
   04917 Prolactin signaling pathway
    K04697  SOCS4; suppressor of cytokine signaling 4
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K04697  SOCS4; suppressor of cytokine signaling 4
KEGG modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00388  ECS complex
     K04697  SOCS4; suppressor of cytokine signaling 4
 Functional set
  Cellular processes
   Cell signaling
    M00684  JAK-STAT signaling
     K04697  SOCS4; suppressor of cytokine signaling 4
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  multi subunit Ring-finger type E3
   ECS complex
    target recognizing subunit (SOCS box)
     K04697  SOCS4; suppressor of cytokine signaling 4
BRITE hierarchy
Genes
HSA: 
122809(SOCS4)
PTR: 
452919(SOCS4)
PPS: 
100989690(SOCS4)
GGO: 
101131192(SOCS4)
PON: 
100171842(SOCS6)
NLE: 
100590972(SOCS6)
MCC: 
696146(SOCS4)
MCF: 
102141350(SOCS4)
CJC: 
100386210(SOCS4)
MMU: 
67296(Socs4)
RNO: 
305828(Socs4)
CGE: 
100750379(Socs4)
NGI: 
103739222(Socs4)
HGL: 
101704725(Socs4)
OCU: 
100357417(SOCS4)
TUP: 
102468675(SOCS4)
CFA: 
100687271(SOCS4)
AML: 
UMR: 
103673077(SOCS4)
FCA: 
101080974(SOCS4)
PTG: 
102971697(SOCS4)
BTA: 
540412(SOCS4)
BOM: 
102270424(SOCS4)
PHD: 
102333116(SOCS4)
CHX: 
102185842(SOCS4)
OAS: 
101117935(SOCS4)
SSC: 
100302366(SOCS4)
CFR: 
102515584(SOCS4)
BACU: 
103014060(SOCS4)
LVE: 
103076129(SOCS4)
ECB: 
100050301(SOCS4)
MYB: 
102247430(SOCS4)
MYD: 
102767035(SOCS4)
PALE: 
102879275(SOCS4)
MDO: 
100024207(SOCS4)
SHR: 
OAA: 
GGA: 
423557(SOCS4)
MGP: 
APLA: 
101804231(SOCS4)
TGU: 
100230629(SOCS4)
FAB: 
PHI: 
102109006(SOCS4)
FPG: 
101924304(SOCS4)
FCH: 
102048310(SOCS4)
CLV: 
102086690(SOCS4)
ASN: 
102384587(SOCS4)
AMJ: 
102572731(SOCS4)
PSS: 
102453072(SOCS4)
CMY: 
102931468(SOCS4)
ACS: 
100561266(socs4)
PBI: 
103053679(SOCS4)
XTR: 
549828(socs4)
DRE: 
100003691(socs9)
TRU: 
100144313(socs4)
MZE: 
OLA: 
100144385(socs4)
XMA: 
LCM: 
102362805(SOCS4)
CMK: 
103175235(socs4)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ.
  Title
The SOCS box: a tale of destruction and degradation.
  Journal
Trends Biochem Sci 27:235-41 (2002)
  Sequence
[hsa:122809]
Reference
  Authors
Kario E, Marmor MD, Adamsky K, Citri A, Amit I, Amariglio N, Rechavi G, Yarden Y
  Title
Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.
  Journal
J Biol Chem 280:7038-48 (2005)
  Sequence
[hsa:122809]

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