KEGG   ORTHOLOGY: K04707Help
Entry
K04707                      KO                                     
Name
CBL
Definition
E3 ubiquitin-protein ligase CBL [EC:6.3.2.19]
Pathway
ErbB signaling pathway
Ubiquitin mediated proteolysis
Endocytosis
Jak-STAT signaling pathway
T cell receptor signaling pathway
Insulin signaling pathway
Bacterial invasion of epithelial cells
Pathways in cancer
Proteoglycans in cancer
Chronic myeloid leukemia
Disease
H00523  
Noonan syndrome and related disorders
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    K04707  CBL; E3 ubiquitin-protein ligase CBL
   04630 Jak-STAT signaling pathway
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 Organismal Systems
  Immune system
   04660 T cell receptor signaling pathway
    K04707  CBL; E3 ubiquitin-protein ligase CBL
  Endocrine system
   04910 Insulin signaling pathway
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04707  CBL; E3 ubiquitin-protein ligase CBL
   05205 Proteoglycans in cancer
    K04707  CBL; E3 ubiquitin-protein ligase CBL
   05220 Chronic myeloid leukemia
    K04707  CBL; E3 ubiquitin-protein ligase CBL
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    K04707  CBL; E3 ubiquitin-protein ligase CBL
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.19  ubiquitin---protein ligase
     K04707  CBL; E3 ubiquitin-protein ligase CBL
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  single Ring-finger type E3
   CBL protein
    K04707  CBL; E3 ubiquitin-protein ligase CBL
BRITE hierarchy
Genes
HSA: 
23624(CBLC) 867(CBL) 868(CBLB)
PTR: 
451690(CBL) 456117(CBLC) 460566(CBLB)
PPS: 
100984607(CBLB) 100988815(CBL) 100995637(CBLC)
GGO: 
101124684(CBLB) 101134347(CBLC) 101140325(CBL)
PON: 
100446187(CBLC) 100452289(CBLB) 100462634(CBL)
MCC: 
703879 704311(CBL) 713112(CBLC)
MCF: 
102114949(CBLB) 102135911(CBLC) 102137660(CBL)
MMU: 
12402(Cbl) 208650(Cblb) 80794(Cblc)
RNO: 
171136(Cblb) 292699(Cblc) 500985(Cbl)
CGE: 
HGL: 
101710004(Cbl) 101713714(Cblc) 101719173(Cblb)
CFA: 
487965(CBLB) 489369(CBL) 612343(CBLC)
AML: 
100470573(CBL) 100473515(CBLB) 100478173(CBLC)
FCA: 
101095782(CBLC) 101096508(CBL) 101101498(CBLB)
BTA: 
525906(CBLB) 527418(CBL) 615866(CBLC)
BOM: 
102279176(CBL) 102285545(CBLC) 102287221(CBLB)
PHD: 
102317029(CBLB) 102324329(CBLC) 102324436(CBL)
CHX: 
102185385(CBL) 102186998(CBLB) 102187397(CBLC)
SSC: 
100511697(CBLC) 100518854(CBL) 100621690(CBLB)
ECB: 
100061819(CBLB) 100071403(CBL) 100147299(CBLC)
MYB: 
102240403(CBLC) 102242908(CBL) 102245653
MDO: 
100011932(CBLB) 100023698 100031184
SHR: 
100913401(CBLB) 100918278(CBLC) 100920890(CBL)
OAA: 
100089052(CBLB) 100091424
GGA: 
374038(CBL) 418406(CBLB)
MGP: 
100546892 100549952
TGU: 
100226776(CBLB) 100227293(CBL)
FAB: 
101810639(CBL) 101810847(CBLB)
PHI: 
102103093(CBL) 102103800(CBLB)
APLA: 
101789789 101799051(CBLB)
FPG: 
101912806(CBLB) 101919050(CBL)
FCH: 
102053933(CBLB) 102058724(CBL)
CLV: 
102096530(CBL) 102097605(CBLB)
ASN: 
102372644(CBL) 102384451(CBLB)
ACS: 
100561034(cblb) 100568145
XLA: 
431829(cblb-b) 443854(cblb-a)
XTR: 
448509(cblb) 594900(cbl)
DRE: 
492364(cbl) 556277(cblb) 565383(si:ch211-175g6.9)
TRU: 
101063765 101078613
MZE: 
101465135 101484242 101486978
OLA: 
101157475 101158476 101170289
XMA: 
102234614 102237712
LCM: 
102345712(CBL) 102346401
BFO: 
BRAFLDRAFT_60082
CIN: 
100176362
SPU: 
583481 765032
DME: 
Dmel_CG7037(Cbl)
DPO: 
Dpse_GA20050
DAN: 
Dana_GF24399 Dana_GF25100
DER: 
Dere_GG14313
DPE: 
Dper_GL24706
DSI: 
Dsim_GD14094
DWI: 
Dwil_GK18041
DYA: 
Dyak_GE20742
DGR: 
Dgri_GH15065
DMO: 
Dmoj_GI12833
DVI: 
Dvir_GJ12975
AGA: 
AgaP_AGAP005449
AAG: 
AaeL_AAEL009739
CQU: 
CpipJ_CPIJ012193
AME: 
411982(GB16551)
NVI: 
100119672
BMOR: 
101740182
API: 
100159071
PHU: 
Phum_PHUM394550
ISC: 
IscW_ISCW019991
CEL: 
CELE_M02A10.3(sli-1)
CBR: 
CBG08124(Cbr-sli-1)
BMY: 
Bm1_05660
LOA: 
LOAG_05836
TSP: 
Tsp_01088
SMM: 
Smp_005020
HMG: 
100208241
TAD: 
TRIADDRAFT_23727
MBR: 
MONBRDRAFT_36983
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wehrle C, Van Slyke P, Dumont DJ
  Title
Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation.
  Journal
Biochem J 423:375-80 (2009)
Reference
  Authors
Fang D, Wang HY, Fang N, Altman Y, Elly C, Liu YC
  Title
Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.
  Journal
J Biol Chem 276:4872-8 (2001)
Reference
  Authors
Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC
  Title
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.
  Journal
Science 286:309-12 (1999)
Reference
  Authors
Ettenberg SA, Keane MM, Nau MM, Frankel M, Wang LM, Pierce JH, Lipkowitz S
  Title
cbl-b inhibits epidermal growth factor receptor signaling.
  Journal
Oncogene 18:1855-66 (1999)
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