| Entry |
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| Name |
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| Definition |
E3 ubiquitin-protein ligase CBL [EC: 2.3.2.27]
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| Pathway |
| ErbB signaling pathway | | Ubiquitin mediated proteolysis | | Endocytosis | | Insulin signaling pathway | | Bacterial invasion of epithelial cells | | Pathways in cancer | | Proteoglycans in cancer | | Chronic myeloid leukemia |
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| Disease |
| Noonan syndrome and related disorders | | Noonan syndrome |
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| Brite |
KEGG Orthology (KO) [BR:ko00001]
Genetic Information Processing
Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
K04707 CBL; E3 ubiquitin-protein ligase CBL
Environmental Information Processing
Signal transduction
04012 ErbB signaling pathway
K04707 CBL; E3 ubiquitin-protein ligase CBL
Cellular Processes
Transport and catabolism
04144 Endocytosis
K04707 CBL; E3 ubiquitin-protein ligase CBL
Organismal Systems
Endocrine system
04910 Insulin signaling pathway
K04707 CBL; E3 ubiquitin-protein ligase CBL
Human Diseases
Cancers
05200 Pathways in cancer
K04707 CBL; E3 ubiquitin-protein ligase CBL
05205 Proteoglycans in cancer
K04707 CBL; E3 ubiquitin-protein ligase CBL
05220 Chronic myeloid leukemia
K04707 CBL; E3 ubiquitin-protein ligase CBL
Infectious diseases
05100 Bacterial invasion of epithelial cells
K04707 CBL; E3 ubiquitin-protein ligase CBL
Enzymes [BR:ko01000]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.27 RING-type E3 ubiquitin transferase
K04707 CBL; E3 ubiquitin-protein ligase CBL
Membrane trafficking [BR:ko04131]
Endocytosis
Clathrin-mediated endocytosis
Ubiquitin E3 ligases
K04707 CBL; E3 ubiquitin-protein ligase CBL
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
Single Ring-finger type E3
CBL proteins
K04707 CBL; E3 ubiquitin-protein ligase CBL
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | NLE: | | MCC: | | MCF: | | CSAB: | | RRO: | | RBB: | | CJC: | | SBQ: | | MMU: | | RNO: | | CGE: | | NGI: | | HGL: | | CCAN: | | OCU: | | TUP: | | CFA: | | AML: | | UMR: | | ORO: | | FCA: | | PTG: | | AJU: | | BTA: | | BOM: | | BIU: | | PHD: | | CHX: | | OAS: | | SSC: | | CFR: | | CDK: | | BACU: | | LVE: | | OOR: | | ECB: | | EPZ: | | EAI: | | MYB: | | MYD: | | HAI: | | RSS: | | PALE: | | LAV: | | TMU: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | CJO: | | APLA: | | ACYG: | | TGU: | | GFR: | | FAB: | | PHI: | | PMAJ: | | CCW: | | FPG: | | FCH: | | CLV: | | EGZ: | | AAM: | | ASN: | | AMJ: | | PSS: | | CMY: | | CPIC: | | ACS: | | PVT: | | PBI: | | GJA: | | XLA: | | XTR: | | NPR: | | DRE: | | SRX: | | SANH: | | SGH: | | CCAR: | | IPU: | | AMEX: | | TRU: | | TNG: | | LCO: | | NCC: | | MZE: | | OLA: | | XMA: | | PRET: | | NFU: | | CSEM: | | LCF: | | HCQ: | | BPEC: | | SASA: | | ELS: | | SFM: | | LCM: | | CMK: | | BFO: | | CIN: | | APLC: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | MDE: | | AGA: | | AAG: | | CQU: | | AME: | | BIM: | | BTER: | | SOC: | | AEC: | | ACEP: | | PBAR: | | HST: | | CFO: | | LHU: | | PGC: | | NVI: | | TCA: | | DPA: | | NVL: | | BMOR: | | PMAC: | | PRAP: | | PXY: | | API: | | DNX: | | PHU: | | ZNE: | | FCD: | | ISC: | | TUT: | | CEL: | | CBR: | | NAI: | | BMY: | | LOA: | | TSP: | | HRO: | | CRG: | | MYI: | | OBI: | | LAK: | | SMM: | | SHX: | | OVI: | | TAD: | | MBR: | | SRE: | |
» show all
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| Reference |
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| Authors |
Wehrle C, Van Slyke P, Dumont DJ |
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| Title |
Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation. |
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| Journal |
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| Reference |
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| Authors |
Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC |
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| Title |
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. |
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| Journal |
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| Sequence |
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