KEGG ORTHOLOGY: K04707

ORTHOLOGY: K04707

Entry

K04707                      KO

Symbol

CBL

Name

E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]

Pathway

map04012

ErbB signaling pathway

map04120

Ubiquitin mediated proteolysis

map04144

Endocytosis

map04910

Insulin signaling pathway

map05100

Bacterial invasion of epithelial cells

map05200

Pathways in cancer

map05205

Proteoglycans in cancer

map05220

Chronic myeloid leukemia

Disease

H00523

Noonan syndrome and related disorders

H02190

CBL syndrome

H02410

Myelodysplastic/myeloproliferative neoplasms

H02411

Chronic myelomonocytic leukemia

H02412

Atypical chronic myeloid leukemia

H02541

Juvenile myelomonocytic leukemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04707  CBL; E3 ubiquitin-protein ligase CBL
09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K04707  CBL; E3 ubiquitin-protein ligase CBL
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04707  CBL; E3 ubiquitin-protein ligase CBL
09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04707  CBL; E3 ubiquitin-protein ligase CBL
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04707  CBL; E3 ubiquitin-protein ligase CBL
   05205 Proteoglycans in cancer
    K04707  CBL; E3 ubiquitin-protein ligase CBL
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    K04707  CBL; E3 ubiquitin-protein ligase CBL
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    K04707  CBL; E3 ubiquitin-protein ligase CBL
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K04707  CBL; E3 ubiquitin-protein ligase CBL
   04121 Ubiquitin system
    K04707  CBL; E3 ubiquitin-protein ligase CBL
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K04707  CBL; E3 ubiquitin-protein ligase CBL
Membrane trafficking [BR:ko04131]
Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    K04707  CBL; E3 ubiquitin-protein ligase CBL
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Single Ring-finger type E3
   CBL proteins
    K04707  CBL; E3 ubiquitin-protein ligase CBL

Genes

HSA:

867(CBL)

PTR:	451690(CBL)

PPS:	100988815(CBL)

GGO:	101140325(CBL)

PON:	100462634(CBL)

NLE:	100607272(CBL)

HMH:	116477056(CBL)

MCC:	704311(CBL)

MCF:	102137660(CBL)

MTHB:

126936575

MNI:	105476372(CBL)

CSAB:

103248629(CBL)

CATY:

105582510(CBL)

PANU:

101005565(CBL)

TGE:	112605765(CBL)

MLEU:

105528294(CBL)

RRO:	104657236(CBL)

RBB:	108528599(CBL)

TFN:	117081759(CBL)

PTEH:

111540239(CBL)

CANG:

105501218(CBL)

CJC:	100408313(CBL)

SBQ:	101053489(CBL)

CIMI:

108300640(CBL)

CSYR:

103270724(CBL)

MMUR:

105876096(CBL)

LCAT:

123641479(CBL)

PCOQ:

105819255(CBL)

OGA:	100958294(CBL)

MMU:	12402(Cbl)

MCAL:

110301174(Cbl)

MPAH:

110327640(Cbl)

RNO:	500985(Cbl)

MCOC:

116073545(Cbl)

ANU:	117698924(Cbl)

MUN:	110562581(Cbl)

CGE:	100754737(Cbl)

MAUA:

101827577(Cbl)

PROB:

127231592(Cbl)

PLEU:

114691162(Cbl)

MORG:

121438406(Cbl)

MFOT:

126487354

AAMP:

119809631(Cbl)

NGI:	103727895(Cbl)

HGL:	101710004(Cbl)

CPOC:

100725041(Cbl)

CCAN:

109696224(Cbl)

DORD:

105980619(Cbl)

DSP:	122110362(Cbl)

PLOP:

125349649(Cbl)

NCAR:

124958961

MMMA:

107145778(Cbl)

OCU:

100342595

OPI:	101522794(CBL)

TUP:	102469580(CBL)

GVR:	103587552 103592896(CBL)

CFA:	489369(CBL)

CLUD:

112671204(CBL)

VVP:	112920322(CBL)

VLG:	121499521(CBL)

NPO:	129497161(CBL)

AML:	100470573(CBL)

UMR:	103662312(CBL)

UAH:	113259962(CBL)

UAR:	123792654(CBL)

ELK:

111153838

LLV:

125080015

MPUF:

101671911(CBL)

MNP:	132026971(CBL)

MLK:	131837043(CBL)

NVS:	122912363(CBL)

ORO:	101377544(CBL)

EJU:	114211393(CBL)

ZCA:	113914209(CBL)

MLX:	118013312(CBL)

NSU:	110586163(CBL)

LWW:	102740110(CBL)

FCA:	101096508(CBL)

PYU:	121035512(CBL)

PBG:	122483059(CBL)

PVIV:

125176046(CBL)

LRUF:

124504852

PTG:	102960753(CBL)

PPAD:

109278523(CBL)

PUC:

125908921

AJU:

106983886

HHV:	120229982(CBL)

BTA:	527418(CBL)

BOM:	102279176(CBL)

BIU:	109568806(CBL)

BBUB:

102409714(CBL)

BBIS:

104981392(CBL)

CHX:	102185385(CBL)

OAS:	101115401(CBL)

BTAX:

128060264(CBL)

ODA:	120876334(CBL)

CCAD:

122450328(CBL)

MBEZ:

129554414(CBL)

SSC:	100518854(CBL)

CFR:	102504124(CBL)

CBAI:

105067865(CBL)

CDK:	105090203(CBL)

VPC:	102534267(CBL)

BACU:

103016132(CBL)

BMUS:

118899117(CBL)

LVE:	103082495(CBL)

OOR:	101270049(CBL)

DLE:	111167490(CBL)

PCAD:

102994124(CBL)

PSIU:

116757571(CBL)

NASI:

112403958(CBL)

ECB:	100071403(CBL)

EPZ:	103546643(CBL)

EAI:	106840308(CBL)

MYB:	102242908(CBL)

MYD:	102763080(CBL)

MMYO:

118664184(CBL)

MLF:	102420957(CBL)

PKL:	118710572(CBL)

EFUS:

103293808(CBL)

MNA:	107533071(CBL)

DRO:	112314205(CBL)

SHON:

119001927(CBL)

AJM:	119050746(CBL)

PDIC:

114499969(CBL)

PHAS:

123818694(CBL)

MMF:	118628368(CBL)

PPAM:

129085961(CBL)

HAI:	109393876(CBL)

RFQ:	117029983(CBL)

PALE:

102895335(CBL)

PGIG:

120605700(CBL)

PVP:	105308867(CBL)

RAY:	107507930(CBL)

MJV:

108409307

TOD:	119240755(CBL)

SARA:

101548296(CBL)

SETR:

126015478(CBL)

LAV:	100658892(CBL)

TMU:

101342874

ETF:	101649648(CBL)

DNM:	101417843(CBL)

MDO:	100031184(CBL)

GAS:	123242116(CBL)

SHR:	100920890(CBL)

PCW:	110207221(CBL)

OAA:	100091424(CBL)

GGA:	374038(CBL)

PCOC:

116233127(CBL)

MGP:	100549952(CBL)

CJO:	107324207(CBL)

TPAI:

128087580(CBL)

LMUT:

125703652(CBL)

NMEL:

110387634(CBL)

APLA:

101789789(CBL)

ACYG:

106039784(CBL)

CATA:

118252523(CBL)

AFUL:

116497942(CBL)

TGU:	100227293(CBL)

LSR:	110475970(CBL)

SCAN:

103823039(CBL)

PMOA:

120508373(CBL)

OTC:	121340814(CBL)

PRUF:

121350077(CBL)

GFR:	102036440(CBL)

FAB:	101810639(CBL)

OMA:	130262502(CBL)

PHI:	102103093(CBL)

PMAJ:

107214346(CBL)

CCAE:

111939301(CBL)

CCW:	104692188(CBL)

CBRC:

103618587(CBL)

ETL:	114067820(CBL)

ZAB:	102061348(CBL)

ACHL:

103800205

SVG:	106858164(CBL)

MMEA:

130584689(CBL)

HRT:	120762499(CBL)

FPG:	101919050(CBL)

FCH:	102058724(CBL)

CLV:	102096530(CBL)

EGZ:	104125948(CBL)

NNI:	104008757 104019053

PCRI:

104037646(CBL)

PLET:

104620198(CBL)

EHS:	104507582(CBL)

PCAO:

104043625

ACUN:

113488489(CBL)

TALA:

104368409(CBL)

PADL:

103921583(CBL)

AFOR:

103906116(CBL)

ACHC:

115344564(CBL)

HALD:

104313808(CBL)

HLE:	104840490(CBL)

AGEN:

126038409

GCL:

127025802

CCRI:

104166982(CBL)

CSTI:

104560243(CBL)

CMAC:

104478039

MUI:	104542704(CBL)

BREG:

104638014(CBL)

FGA:	104076224(CBL)

GSTE:

104250925(CBL)

LDI:

104343605

MNB:	103773104(CBL)

OHA:	104336440(CBL)

NNT:

104407655

SHAB:

115616290(CBL)

DPUB:

104300966(CBL)

PGUU:

104470055(CBL)

ACAR:

104526176(CBL)

CPEA:

104386069(CBL)

AVIT:

104267046(CBL)

CVF:	104284171(CBL)

RTD:	128918584(CBL)

CUCA:

104067203(CBL)

TEO:	104375301(CBL)

AAM:	106495869(CBL)

AROW:

112978641(CBL)

NPD:	112948718(CBL)

TGT:	104572279(CBL)

DNE:	112986521(CBL)

SCAM:

104141124(CBL)

ASN:	102372644(CBL)

AMJ:	106737050(CBL)

CPOO:

109318060(CBL)

GGN:	109292736(CBL)

PSS:	102450818(CBL)

CMY:	102937369(CBL)

CCAY:

125625534(CBL) 125625729(CBLC)

DCC:	119846645(CBL) 119848059(CBLC)

CPIC:

101937375(CBL)

TST:	117868510(CBL)

CABI:

116824914(CBL)

MRV:	120375674(CBL) 120390287(CBLC)

ACS:	100568145(cbl)

ASAO:

132782292(CBL)

PVT:	110078535(CBL)

SUND:

121916237(CBLC) 121934432(CBL)

PBI:	103056422(CBL)

PMUR:

107285391(CBL)

CTIG:

120311285(CBL) 120312027(CBLC)

PGUT:

117670258(CBL) 117677677(CBLC)

APRI:

131203704(CBL) 131204420(CBLC)

PTEX:

113441788(CBL) 113446021(CBLC)

NSS:	113421163(CBLC) 113425728(CBL)

VKO:	123028029(CBL)

PMUA:

114585772(CBL)

PRAF:

128403237(CBL) 128418305(CBLC)

ZVI:	118096707(CBL)

HCG:	128333589(CBL)

GJA:	107105501(CBL)

STOW:

125441931(CBL)

EMC:	129342107(CBL) 129343170(CBLC)

XLA:	108705407(cbl.S) 398194(cbl.L)

XTR:	594900(cbl)

NPR:	108797509(CBL)

RTEM:

120915208(CBL)

BBUF:

120995652(CBL)

BGAR:

122928985(CBL)

MUO:	115481418(CBL)

GSH:	117345646 117347186(CBL)

DRE:	492364(cbl)

SRX:	107718267 107743711(cbl) 107743732

SANH:

107683813(cbl) 107690460

SGH:	107585540(cbl) 107601723

CCAR:

109103193(cbl) 109103196

CAUA:

113058436 113115080

CGIB:

127973172 128029226

PTET:

122359556(cbl)

LROH:

127177006(cbl)

OMC:	131520328(cbl)

PPRM:

120478520(cbl)

RKG:	130096733(cbl)

MAMB:

125248189(cbl) 125248821

CIDE:

127494918

MASI:

127421729 127429782

TROS:

130564410(cbl)

TDW:	130428528(cbl)

MANU:

129437995(cbl)

IPU:

108277804

IFU:	128621799(cbl)

PHYP:

113532779(cbl)

SMEO:

124395053(cbl)

TFD:	113660469(cbl)

TVC:	132858291(cbl)

AMEX:

103032411(cbl)

CMAO:

118800728(cbl)

EEE:	113579444(cbl)

CHAR:

105912771(cbl)

TRU:	101070370 101078613(cbl)

TFS:	130534686(cbl) 130538061

TNG:	GSTEN00000584G001 GSTEN00014895G001 GSTEN00019472G001

LCO:	104921108 104936425(cbl)

NCC:	104965384(cbl)

TBEN:

117470234(cbl) 117490235

CGOB:

115017572(cbl) 115018877

PGEO:

117457166(cbl)

GACU:

117547104 117552199(cbl)

EMAC:

134872179 134880721(cbl)

ELY:	117259724(cbl) 117269000

EFO:	125888610(cbl) 125898957

PLEP:

121942900(cbl) 121952169

SLUC:

116047981(cbl) 116056043

ECRA:

117938122(cbl) 117955431

ESP:	116687126(cbl) 116700199

PFLV:

114552357(cbl) 114566816

GAT:	120815782(cbl) 120822930

PPUG:

119195101(cbl) 119215469

AFB:	129105108(cbl) 129113104

CLUM:

117741864(cbl) 117743080

PSWI:

130188233 130210995(cbl)

MSAM:

119883306(cbl) 119894978

SCHU:

122879350(cbl) 122887977

CUD:	121518567 121518965(cbl)

ALAT:

119009562(cbl) 119031157

MZE:	101465135(cbl) 101471367 101484693

ONL:	100692645 100710684(cbl)

OAU:	116326358 116328176(cbl)

OLA:	101163758 101170289(cbl)

OML:	112142874 112149910(cbl)

CSAI:

133441741(cbl) 133459949

XMA:	102233950 102234614(cbl)

XCO:	114133667(cbl) 114153038

XHE:	116708259(cbl) 116728232

PRET:

103474573(cbl) 103476312

PFOR:

103136255(cbl) 103145535

PLAI:

106946273 106950063(cbl)

PMEI:

106904204(cbl) 106915552

GAF:	122833186(cbl) 122844650

PPRL:

129359453(cbl) 129370599

CVG:	107088320(cbl) 107098202

CTUL:

119782816(cbl)

GMU:	124876272 124883956(cbl)

NFU:	107380353(cbl) 107387219

KMR:	108238085 108246038(cbl)

ALIM:

106515461(cbl) 106525419

NWH:	119411219(cbl) 119420818

AOCE:

111586006 111587912(cbl)

MCEP:

125012993(cbl) 125021255

CSEM:

103378406(cbl) 103395395

POV:	109630213(cbl) 109635803

SSEN:

122773260(cbl) 122779910

HHIP:

117772967(cbl) 117773983

HSP:	118106564(cbl) 118122095

SMAU:

118298997(cbl) 118300625

LCF:	108886386 108893685

SDU:	111217085 111228025(cbl)

SLAL:

111651622 111652625(cbl)

XGL:	120791753(cbl) 120802301

HCQ:	109517915 109529378(cbl)

SSCV:

125972712 125982505

SBIA:

133491831 133505110(cbl)

PEE:	133405014(cbl) 133415944

PTAO:

133467753 133481864(cbl)

BPEC:

110154105(cbl) 110174966

MALB:

109959267 109960188(cbl)

BSPL:

114867979(cbl) 114869982

SJO:	128360348(cbl)

SASA:

106567671 106603416 106612473(cbl)

STRU:

115148783 115154245 115162940(cbl) 115205894

OTW:	112228511 112244677 112257934 112266723

OMY:	110503541 110507383(cbl) 110533571 110537552

OGO:	123993104 123998926 124005958 124011372

ONE:	115105473 115135975 115137119 115141495

OKI:	109872641 109892805 109905383(cbl) 109908866

OKE:	118386314 118390018 118391095 118396807(cbl)

SALP:

111949371(cbl) 111951111 111981389

SNH:	120018426 120028686 120030821 120057009

CCLU:

121550913 121560841 121567354 121579371

ELS:	105011087 105012434(cbl)

SFM:	108928618 108936164

PKI:	111846264 111851345

AANG:

118209689(cbl) 118235559

LOC:	102693589(cbl)

PSPA:

121302617 121309453(cbl)

ARUT:

117397057 117433827(cblc) 117962485 117964825

PSEX:

120535976(cbl)

LCM:	102345712(CBL) 102349292(CBLC)

CMK:	103191373(cbl)

RTP:

109922666

CPLA:

122541123(cbl)

HOC:	132829718(cbl)

LERI:

129712286(cbl)

BFO:

BBEL:

CIN:

SPU:

APLC:

AJC:

DME:	Dmel_CG7037(Cbl)

DER:

6545674

DSE:

116801240

DSI:	Dsimw501_GD14094(Dsim_GD14094)

DYA:	Dyak_GE20742

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12833

DAZ:

DNV:

DHE:

DVI:

BOD:

BDR:

RZE:	108355018 108376206

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

HIS:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AAG:

AALB:

CQU:	CpipJ_CPIJ012192

CPII:

CNS:

BCOO:

AME:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM394550

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DMK:	116930129 123466572

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:	111258721 111265193

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_M02A10.3(sli-1)

CBR:	CBG_08124(Cbr-sli-1)

CRQ:	GCK72_022194

NAI:	NECAME_04660

BMY:	BM_BM5061(Bma-sli-1)

LOA:	LOAG_05836

TSP:

Tsp_01088

HRO:	HELRODRAFT_179710

PVUL:

126829708

PCAN:

112567631

BGT:

106052457

GAE:	121386551 121391391

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_005020

SHX:	MS3_00004097

OVI:	T265_13011

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_23727

MBR:	MONBRDRAFT_36983

SRE:	PTSG_09506

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Reference

PMID:19689429

Authors

Wehrle C, Van Slyke P, Dumont DJ

Title

Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation.

Journal

Biochem J 423:375-80 (2009)
DOI:10.1042/BJ20091010

Reference

PMID:10514377

Authors

Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC

Title

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.

Journal

Science 286:309-12 (1999)
DOI:10.1126/science.286.5438.309

Sequence

[hsa:867]

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