KEGG   ORTHOLOGY: K04707Help
Entry
K04707                      KO                                     

Name
CBL
Definition
E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]
Pathway
ErbB signaling pathway
Ubiquitin mediated proteolysis
Endocytosis
T cell receptor signaling pathway
Insulin signaling pathway
Bacterial invasion of epithelial cells
Pathways in cancer
Proteoglycans in cancer
Chronic myeloid leukemia
Disease
H00523  
Noonan syndrome and related disorders
H01738  
Noonan syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 Organismal Systems
  Immune system
   04660 T cell receptor signaling pathway
    K04707  CBL; E3 ubiquitin-protein ligase CBL
  Endocrine system
   04910 Insulin signaling pathway
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04707  CBL; E3 ubiquitin-protein ligase CBL
   05205 Proteoglycans in cancer
    K04707  CBL; E3 ubiquitin-protein ligase CBL
   05220 Chronic myeloid leukemia
    K04707  CBL; E3 ubiquitin-protein ligase CBL
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    K04707  CBL; E3 ubiquitin-protein ligase CBL
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K04707  CBL; E3 ubiquitin-protein ligase CBL
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    K04707  CBL; E3 ubiquitin-protein ligase CBL
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   CBL proteins
    K04707  CBL; E3 ubiquitin-protein ligase CBL
BRITE hierarchy
Genes
HSA: 
23624(CBLC) 867(CBL) 868(CBLB)
PTR: 
451690(CBL) 456117(CBLC) 460566(CBLB)
PPS: 
100984607(CBLB) 100988815(CBL) 100995637(CBLC)
GGO: 
101124684(CBLB) 101134347(CBLC) 101140325(CBL)
PON: 
100446187(CBLC) 100452289(CBLB) 100462634(CBL)
NLE: 
MCC: 
703879(CBLB) 704311(CBL) 713112(CBLC)
MCF: 
102114949(CBLB) 102135911(CBLC) 102137660(CBL)
CSAB: 
103228406(CBLB) 103234836(CBLC) 103248629(CBL)
RRO: 
104657236(CBL) 104673466(CBLC) 104674409(CBLB)
CJC: 
100400634(CBLC) 100408313(CBL) 100409801(CBLB)
SBQ: 
101035841(CBLB) 101053489(CBL) 104653275(CBLC)
MMU: 
12402(Cbl) 208650(Cblb) 80794(Cblc)
RNO: 
171136(Cblb) 292699(Cblc) 500985(Cbl)
CGE: 
100751369(Cblc) 100754737(Cbl) 100774600(Cblb)
NGI: 
103727895(Cbl) 103747585(Cblb) 103749240(Cblc)
HGL: 
101710004(Cbl) 101713714(Cblc) 101719173(Cblb)
CCAN: 
109692362(Cblc) 109696224(Cbl) 109699003(Cblb) 109699297
OCU: 
100342595(CBL) 100355469(CBLB) 100357032(CBLC)
TUP: 
102469580(CBL) 102485272(CBLB) 102487610(CBLC)
CFA: 
487965(CBLB) 489369(CBL) 612343(CBLC)
AML: 
100470573(CBL) 100473515(CBLB) 105239774(CBLC)
UMR: 
103657173(CBLC) 103662312(CBL) 103677350(CBLB)
FCA: 
101095782(CBLC) 101096508(CBL) 101101498(CBLB)
PTG: 
102960753(CBL) 102962133(CBLB) 102962448(CBLC)
AJU: 
106972259(CBLB) 106983886(CBL)
BTA: 
525906(CBLB) 527418(CBL) 615866(CBLC)
BOM: 
102279176(CBL) 102285545(CBLC) 102287221(CBLB)
BIU: 
109568806(CBL) 109568926(CBLB) 109572739(CBLC)
PHD: 
102317029(CBLB) 102324329(CBLC) 102324436(CBL)
CHX: 
102185385(CBL) 102186998(CBLB) 102187397(CBLC)
OAS: 
101111043(CBLC) 101114404(CBLB) 101115401(CBL)
SSC: 
100511697(CBLC) 100518854(CBL) 100621690(CBLB)
CFR: 
102504124(CBL) 102508318(CBLC) 102515465(CBLB)
BACU: 
103002776(CBLB) 103003237(CBLC) 103016132(CBL)
LVE: 
103069946(CBLC) 103082495(CBL) 103083966(CBLB)
ECB: 
100061819(CBLB) 100071403(CBL) 100147299(CBLC)
MYB: 
102240403(CBLC) 102242908(CBL) 102245653(CBLB)
MYD: 
102759944(CBLB) 102761297(CBLC) 102763080(CBL)
HAI: 
109372778(CBLC) 109393876(CBL) 109395019(CBLB)
PALE: 
102884917(CBLC) 102890283(CBLB) 102895335(CBL)
LAV: 
100658892(CBL) 100669076(CBLC) 100669603(CBLB)
MDO: 
100011932(CBLB) 100023698(CBLC) 100031184(CBL)
SHR: 
100913401(CBLB) 100918278(CBLC) 100920890(CBL)
OAA: 
100089052(CBLB) 100091424
GGA: 
374038(CBL) 418406(CBLB)
MGP: 
100546892(CBLB) 100549952(CBL)
CJO: 
107321076(CBLB) 107324207(CBL)
APLA: 
101789789(CBL) 101799051(CBLB)
TGU: 
100226776(CBLB) 100227293(CBL)
GFR: 
102033221(CBLB) 102036440(CBL)
FAB: 
101810639(CBL) 101810847(CBLB)
PHI: 
102103093(CBL) 102103800(CBLB)
CCW: 
104687176(CBLB) 104692188(CBL)
FPG: 
101912806(CBLB) 101919050(CBL)
FCH: 
102053933(CBLB) 102058724(CBL)
CLV: 
102096530(CBL) 102097605(CBLB)
AAM: 
106490686(CBLB) 106495869(CBL)
ASN: 
102372644(CBL) 102384451(CBLB)
AMJ: 
102563760(CBLB) 106737050(CBL)
PSS: 
102450818(CBL) 102454526(CBLB)
CMY: 
102937369(CBL) 102943844(CBLB)
CPIC: 
101937375(CBL) 101939160(CBLC) 101947986(CBLB)
ACS: 
100552102 100561034(cblb) 100568145(cbl)
PBI: 
103056422(CBL) 103059707(CBLB) 103066304(CBLC) 103067394
GJA: 
107105501(CBL) 107121592(CBLB) 107122746
XLA: 
108697772 108705407(cbl.S) 398194(cbl.L) 431829(cblb.S) 443854(cblb.L)
XTR: 
100489764(cblc) 448509(cblb) 594900(cbl)
DRE: 
492364(cbl) 556277(cblb) 565383(cblc)
IPU: 
108269225 108276857(cblb) 108277804(cbl)
TRU: 
101063765(cblb) 101070370 101078613(cbl)
TNG: 
GSTEN00000584G001 GSTEN00005248G001 GSTEN00014895G001 GSTEN00016328G001 GSTEN00019472G001 GSTEN00037130G001
LCO: 
104921108 104927341(cblc) 104935532(cblb) 104936425(cbl) 109143152
MZE: 
101465135(cbl) 101471367 101484242(cblb) 101484693 101486978(cblc)
OLA: 
101157475(cblb) 101158476 101163758 101170289(cbl)
XMA: 
102233950 102234614(cbl) 102237712(cblc)
SASA: 
106567671 106577440 106602828(cblb) 106603416 106605677 106612473(cbl)
LCM: 
102345712(CBL) 102346401(CBLB) 102349292(CBLC) 102358138
CMK: 
103172728 103180132(cblb) 103190597(cbl) 103191373
BFO: 
BRAFLDRAFT_60082
CIN: 
100176362
SPU: 
100890602
SKO: 
102808048
DME: 
Dmel_CG7037(Cbl)
DPO: 
Dpse_GA20050
DAN: 
Dana_GF24399 Dana_GF25100
DER: 
Dere_GG14313
DPE: 
Dper_GL24706
DSI: 
Dsimw501_GD14094(Dsim_GD14094)
DWI: 
Dwil_GK18041
DYA: 
Dyak_GE20742
DGR: 
Dgri_GH15065
DMO: 
Dmoj_GI12833
DVI: 
Dvir_GJ12975
MDE: 
101900304
AGA: 
AgaP_AGAP005449
AAG: 
AaeL_AAEL009739
CQU: 
CpipJ_CPIJ012193 CpipJ_CPIJ012195
AME: 
411982
BIM: 
100745466
BTER: 
100642596
SOC: 
105202310
AEC: 
105147762
HST: 
105191070
CFO: 
105249224
NVI: 
100119672
TCA: 
656167
BMOR: 
101740182
DPL: 
KGM_12927 KGM_19773
PXY: 
105391330
API: 
100159071
PHU: 
Phum_PHUM394550
ISC: 
IscW_ISCW019991
CEL: 
CELE_M02A10.3(sli-1)
CBR: 
CBG08124(Cbr-sli-1)
BMY: 
Bm1_05660
LOA: 
LOAG_05836
TSP: 
Tsp_01088
HRO: 
HELRODRAFT_156201 HELRODRAFT_178287 HELRODRAFT_179709 HELRODRAFT_179710
LGI: 
LOTGIDRAFT_156016
CRG: 
105342258
OBI: 
106869207
SMM: 
Smp_005020
ADF: 
107345262
HMG: 
100208241
TAD: 
TRIADDRAFT_23727
AQU: 
100639103
MBR: 
MONBRDRAFT_36983
SRE: 
PTSG_09506
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wehrle C, Van Slyke P, Dumont DJ
  Title
Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation.
  Journal
Biochem J 423:375-80 (2009)
DOI:10.1042/BJ20091010
  Sequence
[hsa:867]
Reference
  Authors
Fang D, Wang HY, Fang N, Altman Y, Elly C, Liu YC
  Title
Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.
  Journal
J Biol Chem 276:4872-8 (2001)
DOI:10.1074/jbc.M008901200
  Sequence
[hsa:868]
Reference
  Authors
Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC
  Title
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.
  Journal
Science 286:309-12 (1999)
DOI:10.1126/science.286.5438.309
  Sequence
[hsa:867]
Reference
  Authors
Ettenberg SA, Keane MM, Nau MM, Frankel M, Wang LM, Pierce JH, Lipkowitz S
  Title
cbl-b inhibits epidermal growth factor receptor signaling.
  Journal
Oncogene 18:1855-66 (1999)
DOI:10.1038/sj.onc.1202499
  Sequence
[hsa:868]
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