KEGG   ORTHOLOGY: K04710Help
Entry
K04710                      KO                                     
Name
CERS
Definition
ceramide synthetase [EC:2.3.1.24]
Pathway
Sphingolipid metabolism
Module
M00094  
Ceramide biosynthesis
M00099  
Sphingosine biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00600 Sphingolipid metabolism
    K04710  CERS; ceramide synthetase
KEGG pathway modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Lipid metabolism
    M00094  Ceramide biosynthesis
     K04710  CERS; ceramide synthetase
    M00099  Sphingosine biosynthesis
     K04710  CERS; ceramide synthetase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.24  sphingosine N-acyltransferase
     K04710  CERS; ceramide synthetase
BRITE hierarchy
Other DBs
Genes
HSA: 
10715(CERS1) 204219(CERS3) 253782(CERS6) 29956(CERS2) 79603(CERS4) 91012(CERS5)
PTR: 
451891(LASS5) 453683(LASS3) 456435(LASS4) 468773(LASS1) 469482(LASS2) 741293(LASS6)
PPS: 
100968130(CERS1) 100973710(CERS4) 100973768(CERS2) 100980816(CERS5) 100985038(CERS6) 100994802(CERS3)
GGO: 
101126713 101128445(CERS3) 101131101(CERS4) 101131185(CERS5) 101148109(CERS2)
PON: 
100174286(LASS2) 100437726(CERS4) 100447528 100451535(CERS3) 100452162(CERS6) 100454836(CERS5)
MCC: 
693696(LASS3) 704953(LASS6) 706728(LASS4) 713449(LASS5) 716180(LASS2)
MMU: 
241447(Cers6) 545975(Cers3) 67260(Cers4) 71949(Cers5) 76893(Cers2) 93898(Cers1)
RNO: 
290658(Cers1) 304208(Cers4) 310667(Cers2) 366065(Cers6) 366984(Cers5) 499174(Cers3)
CFA: 
477611(CERS5) 483187(CERS2) 485008(CERS4) 488387(CERS6) 607925(CERS3) 609789(CERS1)
AML: 
FCA: 
101084386(CERS6) 101087243(CERS5) 101089084(CERS1) 101093918(CERS4) 101094362(CERS2) 101099301(CERS3)
BTA: 
505233(CERS4) 530776(CERS5) 539223(CERS2) 614354(CERS3) 615296(CERS1) 616901(CERS6)
SSC: 
100126279(LASS6) 100127167(LASS4) 100152265(LASS3) 100156737(LASS2) 100525450 100626198
ECB: 
100050135 100052305(LASS6) 100055037(LASS2) 100059999(LASS5) 100066949 100069594
MDO: 
100014952(LASS2) 100016686 100020588 100024030(LASS6) 100025505
SHR: 
100917962(CERS2) 100919047(CERS4) 100919629(CERS3) 100924117(CERS6) 100929507(CERS5) 100934844
OAA: 
100078502 100083235 100090289 100090484
GGA: 
100857262 100859441 420050(LASS4) 426648(CERS3) 426879(CERS5) 428318(LASS4) 771503(CERS6)
MGP: 
100539644 100544401 100547857 100550977
TGU: 
100217479 100224527(CERS3) 100225623(CERS6) 100228761(CERS2) 100230030(CERS1) 100231332(CERS5)
ACS: 
100552770 100554835 100563712 100565999
XLA: 
379135(cers2) 399185(trh4) 444162(cers3) 495501(cers5)
XTR: 
100036728(cers2) 100101657(cers5) 100379773(cers4) 100485129 100489264 448139(cers3)
DRE: 
100330155 259251(cers2a) 323020(cers5) 564867 568169(fb75h07)
TRU: 
101062351 101069548 101069883 101079149 101079773
OLA: 
101156449 101160439 101166466 101175231 101175635
BFO: 
BRAFLDRAFT_104111 BRAFLDRAFT_280654
CIN: 
100101810(lag1-like3) 100184115 778663(lag1-like1)
SPU: 
582683 592336
DME: 
Dmel_CG3576(schlank)
DPO: 
Dpse_GA17532
DER: 
Dere_GG17686
DPE: 
Dper_GL21353
DSE: 
Dsec_GM12585
DWI: 
Dwil_GK25340
DYA: 
Dyak_GE16474
DGR: 
Dgri_GH24802
DMO: 
Dmoj_GI21529
DVI: 
Dvir_GJ16002
AGA: 
AgaP_AGAP001761
AAG: 
AaeL_AAEL009092
CQU: 
CpipJ_CPIJ012963
AME: 
727350(Lag1)
NVI: 
100124217(Lag1)
TCA: 
656449
API: 
100164476
PHU: 
Phum_PHUM115780
ISC: 
IscW_ISCW005009 IscW_ISCW007816 IscW_ISCW018120
CEL: 
CELE_C09G4.1(hyl-1) CELE_K02G10.6(hyl-2) CELE_Y6B3B.10(lagr-1)
CBR: 
CBG13635(Cbr-lagr-1) CBG14524(Cbr-hyl-2) CBG15635(Cbr-hyl-1)
BMY: 
Bm1_06625
TSP: 
Tsp_02045
SMM: 
Smp_042440 Smp_122050
NVE: 
NEMVE_v1g79235 NEMVE_v1g96861
HMG: 
100214724 100215789
TAD: 
TRIADDRAFT_58575
AQU: 
100641959
MTR: 
MTR_4g086150
RCU: 
RCOM_1965760
POP: 
POPTR_811133
DOSA: 
Os03t0264000-01(Os03g0264000)
BDI: 
100822162
SBI: 
SORBI_01g040200(SORBIDRAFT_01g040200) SORBI_04g029190(SORBIDRAFT_04g029190)
ZMA: 
100282886
SMO: 
SELMODRAFT_170071 SELMODRAFT_234046 SELMODRAFT_78320
PPP: 
PHYPADRAFT_115584 PHYPADRAFT_79992
CRE: 
CHLREDRAFT_105088 CHLREDRAFT_41962
VCN: 
VOLCADRAFT_55921
DPP: 
DICPUDRAFT_98903
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Lahiri S, Park H, Laviad EL, Lu X, Bittman R, Futerman AH
  Title
Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner.
  Journal
J Biol Chem 284:16090-8 (2009)
Reference
  Authors
Levy M, Futerman AH
  Title
Mammalian ceramide synthases.
  Journal
IUBMB Life 62:347-56 (2010)
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