KEGG   ORTHOLOGY: K04725Help
Entry
K04725                      KO                                     

Name
XIAP, BIRC4
Definition
E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
Pathway
Platinum drug resistance
NF-kappa B signaling pathway
Ubiquitin mediated proteolysis
Apoptosis
Apoptosis - fly
Apoptosis - multiple species
Focal adhesion
Toxoplasmosis
HTLV-I infection
Pathways in cancer
Small cell lung cancer
Disease
H00107  
Other well-defined immunodeficiency syndromes
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
 Environmental Information Processing
  Signal transduction
   04064 NF-kappa B signaling pathway
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
   04214 Apoptosis - fly
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
   04215 Apoptosis - multiple species
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
  Cellular commiunity
   04510 Focal adhesion
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
   05222 Small cell lung cancer
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
  Infectious diseases
   05166 HTLV-I infection
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
   05145 Toxoplasmosis
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
  Antineoplastic resistance
   01524 Platinum drug resistance
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Mitochondrial dynamics
   Retention of mitochondria
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
BRITE hierarchy
Genes
HSA: 
331(XIAP)
PTR: 
473765(XIAP)
PPS: 
100993738(XIAP)
GGO: 
101133804(XIAP)
PON: 
100449741(XIAP)
NLE: 
100597865(XIAP)
MCC: 
698057(XIAP)
MCF: 
102131393(XIAP)
RRO: 
104655196(XIAP)
CJC: 
100402341(XIAP)
MMU: 
11798(Xiap)
RNO: 
63879(Xiap)
CGE: 
100689374(Xiap)
NGI: 
103734850(Xiap)
HGL: 
101715865(Xiap)
OCU: 
100328700(XIAP)
TUP: 
102500839(XIAP)
CFA: 
442989(XIAP)
AML: 
100471203(XIAP)
UMR: 
103680228(XIAP)
FCA: 
101090594(XIAP)
PTG: 
102957920(XIAP)
BTA: 
281647(XIAP)
BOM: 
102275096(XIAP)
PHD: 
102333718(XIAP)
CHX: 
102170035(XIAP)
OAS: 
101116381(XIAP)
SSC: 
100037300(XIAP)
CFR: 
102507842(XIAP)
BACU: 
103010212(XIAP)
LVE: 
103085092(XIAP)
ECB: 
100060870(XIAP)
MYB: 
102246972(XIAP)
MYD: 
102755332(XIAP)
PALE: 
102885349(XIAP)
MDO: 
100016651(XIAP)
SHR: 
100928240(XIAP)
OAA: 
100079889(XIAP)
GGA: 
395280(XIAP)
MGP: 
100542540(XIAP)
CJO: 
107312953(XIAP)
APLA: 
101796377(XIAP)
TGU: 
100231359(XIAP)
GFR: 
102039585(XIAP)
FAB: 
101819741(XIAP)
PHI: 
102101552(XIAP)
CCW: 
104694440(XIAP)
FPG: 
101916449(XIAP)
FCH: 
102051757(XIAP)
CLV: 
102088054(XIAP)
AAM: 
106487581(XIAP)
ASN: 
102386593(XIAP)
AMJ: 
102570735(XIAP)
PSS: 
102449987(XIAP)
CMY: 
102939941(XIAP)
ACS: 
100557644(xiap)
PBI: 
103053668(XIAP)
GJA: 
107123686(XIAP)
XLA: 
733235(xiap)
XTR: 
594971(xiap)
DRE: 
373108(xiap)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102349446(XIAP)
CMK: 
103178709(xiap)
BFO: 
CIN: 
AME: 
726899(GB12440)
API: 
HMG: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8654366
  Authors
Duckett CS, Nava VE, Gedrich RW, Clem RJ, Van Dongen JL, Gilfillan MC, Shiels H, Hardwick JM, Thompson CB
  Title
A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.
  Journal
EMBO J 15:2685-94 (1996)
  Sequence
[hsa:331]
Reference
  Authors
MacFarlane M, Merrison W, Bratton SB, Cohen GM
  Title
Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro.
  Journal
J Biol Chem 277:36611-6 (2002)
  Sequence
[hsa:331]

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