KEGG   ORTHOLOGY: K04728Help
Entry
K04728                      KO                                     

Name
ATM, TEL1
Definition
ataxia telangiectasia mutated family protein [EC:2.7.11.1]
Pathway
Platinum drug resistance
Homologous recombination
NF-kappa B signaling pathway
FoxO signaling pathway
Cell cycle
p53 signaling pathway
Apoptosis
Apoptosis - fly
Cellular senescence
Human papillomavirus infection
HTLV-I infection
Transcriptional misregulation in cancer
MicroRNAs in cancer
Module
M00295  
BRCA1-associated genome surveillance complex (BASC)
M00691  
DNA damage-induced cell cycle checkpoints
Disease
H00005  
Chronic lymphocytic leukemia (CLL)
H00064  
Ataxia telangiectasia (AT)
H00094  
Immunodeficiency associated with DNA repair defects
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Replication and repair
   03440 Homologous recombination
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
 Environmental Information Processing
  Signal transduction
   04064 NF-kappa B signaling pathway
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
   04068 FoxO signaling pathway
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
   04210 Apoptosis
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
   04214 Apoptosis - fly
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
   04115 p53 signaling pathway
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
   04218 Cellular senescence
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
   05206 MicroRNAs in cancer
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
  Infectious diseases
   05166 HTLV-I infection
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
   05165 Human papillomavirus infection
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
  Drug resistance
   01524 Platinum drug resistance
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
KEGG modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Repair system
    M00295  BRCA1-associated genome surveillance complex (BASC)
     K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
 Functional set
  Cellular processes
   Cell signaling
    M00691  DNA damage-induced cell cycle checkpoints
     K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: Atypical group
  PIKK family [OT]
   K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
DNA replication proteins [BR:ko03032]
 Eukaryotic Type
  DNA Replication Termination Factors
   Other telomere regulation proteins
    Others
     K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  Check point factors
   Other check point factors
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
BRITE hierarchy
Genes
HSA: 
472(ATM)
PTR: 
451530(ATM)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
MCF: 
CSAB: 
RRO: 
CJC: 
SBQ: 
MMU: 
11920(Atm)
RNO: 
300711(Atm)
CGE: 
NGI: 
HGL: 
CCAN: 
OCU: 
TUP: 
CFA: 
479450(ATM)
AML: 
UMR: 
FCA: 
PTG: 
AJU: 
BTA: 
526824(ATM)
BOM: 
BIU: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
HAI: 
RSS: 
PALE: 
LAV: 
MDO: 
SHR: 
OAA: 
GGA: 
395401(ATM)
MGP: 
CJO: 
APLA: 
TGU: 
FAB: 
PHI: 
CCW: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
PSS: 
CMY: 
CPIC: 
ACS: 
PBI: 
GJA: 
XLA: 
398148(atm.L)
XTR: 
DRE: 
403064(atm)
IPU: 
TRU: 
TNG: 
LCO: 
MZE: 
OLA: 
XMA: 
CSEM: 
SASA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
577188(atm)
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD20371(Dsim_GD20371)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
725613(ATM)
BIM: 
BTER: 
SOC: 
AEC: 
PBAR: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
CEL: 
CBR: 
CBG22015(Cbr-atm-1)
NAI: 
BMY: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
OVI: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
GHI: 
EGR: 
GMX: 
PVU: 
VRA: 
VAR: 
CCAJ: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0182159.1(Lj0g3v0182159.1) Lj4g3v0165070.1(Lj4g3v0165070.1)
LANG: 
FVE: 
PPER: 
PMUM: 
MDM: 
ZJU: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
VVI: 
SLY: 
SPEN: 
SOT: 
INI: 
SIND: 
BVG: 
NNU: 
OSA: 
DOSA: 
Os01t0106700-00(Os01g0106700)
OBR: 
BDI: 
ATS: 
ZMA: 
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
OLU: 
OTA: 
BPG: 
MPP: 
CSL: 
CVR: 
GSL: 
CCP: 
SCE: 
YBL088C(TEL1)
AGO: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0E02450(NCAS0E02450)
NDI: 
NDAI_0E04020(NDAI0E04020)
TPF: 
TPHA_0K00690(TPHA0K00690)
TBL: 
TBLA_0D00420(TBLA0D00420)
TDL: 
TDEL_0C02790(TDEL0C02790)
KAF: 
KAFR_0L01900(KAFR0L01900)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
CAUR: 
NCR: 
NCU00274(mus-21)
NTE: 
NEUTE1DRAFT63387(NEUTE1DRAFT_63387)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
FVR: 
FOX: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
CFJ: 
ELA: 
SSL: 
BFU: 
MBE: 
PSCO: 
GLZ: 
ANI: 
AFM: 
AOR: 
AOR_1_694094(AO090120000393)
ANG: 
ANI_1_1604124(An14g06540)
AFV: 
ACT: 
NFI: 
PCS: 
PDP: 
CIM: 
CIMG_12324(CIMG09299)
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
TVS: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT70197(AGABI1DRAFT_70197)
ABV: 
AGABI2DRAFT205907(AGABI2DRAFT_205907)
CPUT: 
SLA: 
PFP: 
PGR: 
MLR: 
MBR: 
SRE: 
EHI: 
EHI_017670(199.t00007)
EDI: 
EIV: 
ACAN: 
SMIN: 
v1.2.029032.t1(symbB.v1.2.029032.t1)
PTI: 
FCY: 
TPS: 
AAF: 
PIF: 
PSOJ: 
SPAR: 
EHX: 
GTT: 
NGR: 
TVA: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8589678
  Authors
Savitsky K, Sfez S, Tagle DA, Ziv Y, Sartiel A, Collins FS, Shiloh Y, Rotman G
  Title
The complete sequence of the coding region of the ATM gene reveals similarity to  cell cycle regulators in different species.
  Journal
Hum Mol Genet 4:2025-32 (1995)
DOI:10.1093/hmg/4.11.2025
  Sequence
[hsa:472]
Reference
  Authors
Sun Y, Xu Y, Roy K, Price BD
  Title
DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.
  Journal
Mol Cell Biol 27:8502-9 (2007)
DOI:10.1128/MCB.01382-07
  Sequence
[hsa:472]

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