KEGG ORTHOLOGY: K04728

ORTHOLOGY: K04728

Entry

K04728 KO

Name

ATM, TEL1

Definition

ataxia telangiectasia mutated family protein [EC:2.7.11.1]

Pathway

ko04064	NF-kappa B signaling pathway
ko04110	Cell cycle
ko04115	p53 signaling pathway
ko04210	Apoptosis
ko05166	HTLV-I infection
ko05202	Transcriptional misregulation in cancer

Module

M00295

BRCA1-associated genome surveillance complex (BASC)

Disease

H00005	Chronic lymphocytic leukemia (CLL)
H00064	Ataxia telangiectasia (AT)
H00094	DNA repair defects
H00848	Ataxia with ocular apraxia (AOA)

Brite

KEGG Orthology (KO) [BR:ko00001]
Environmental Information Processing
  Signal transduction
   04064 NF-kappa B signaling pathway
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
   04210 Apoptosis
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
   04115 p53 signaling pathway
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
  Infectious diseases
   05166 HTLV-I infection
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
KEGG pathway modules [BR:ko00002]
Structural complex
  Genetic information processing
   Repair system
    M00295  BRCA1-associated genome surveillance complex (BASC) [BR:ko03400]
     K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
Protein kinases [BR:ko01001]
Serine/threonine protein kinases: Others
  PIKK family
   K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
DNA replication proteins [BR:ko03032]
Eukaryotic Type
  DNA Replication Termination Factors
   Other telomere regulation proteins
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic Type
  Check point factors
   Other check point factors
    K04728  ATM, TEL1; ataxia telangiectasia mutated family protein

Genes

HSA:	472(ATM)
PTR:	451530(ATM)
PPS:	100982830(ATM)
GGO:	101123696(ATM)
PON:	100451505(ATM)
MCC:	100427400(ATM)
MMU:	11920(Atm)
RNO:	300711(Atm)
CFA:	479450(ATM)
AML:	100480638(ATM)
FCA:	101089291(ATM)
BTA:	526824(ATM)
SSC:	100101922(ATM)
ECB:	100061765(ATM)
MDO:	100026797(ATM)
SHR:	100925167(ATM)
OAA:	100078971(ATM)
GGA:	395401(ATM)
MGP:	100540368(ATM)
TGU:	100217707(ATM)
ACS:	100556408
XLA:	398148(atm)
XTR:	100490767
DRE:	403064(atm)
TRU:	101079070
OLA:	101167063
BFO:	BRAFLDRAFT_88587
CIN:	100175590 100184987
SPU:	577188(atm)
DME:	Dmel_CG6535(tefu)
DPO:	Dpse_GA19668
DAN:	Dana_GF11791
DER:	Dere_GG20781
DPE:	Dper_GL12075
DSE:	Dsec_GM25794
DSI:	Dsim_GD20371
DWI:	Dwil_GK12780
DYA:	Dyak_GE26399
DGR:	Dgri_GH22366
DMO:	Dmoj_GI11054
DVI:	Dvir_GJ14811
AGA:	AgaP_AGAP009632
AAG:	AaeL_AAEL014900
CQU:	CpipJ_CPIJ001772 CpipJ_CPIJ001777
AME:	725613(ATM)
NVI:	100114506(NV17900)
TCA:	660142
API:	100167029
PHU:	Phum_PHUM472530
ISC:	IscW_ISCW016587
CEL:	CELE_Y48G1BL.2(atm-1)
CBR:	CBG22015(Cbr-atm-1)
BMY:	Bm1_40395
SMM:	Smp_157820
NVE:	NEMVE_v1g171012
TAD:	TRIADDRAFT_33879
AQU:	100641266(Atm)
ATH:	AT3G48190(ATM)
ALY:	ARALYDRAFT_323420
GMX:	100788458
MTR:	MTR_3g077860
CSV:	101208785
RCU:	RCOM_1510550
VVI:	100250198
OSA:	4326151
DOSA:	Os01t0106700-00(Os01g0106700)
BDI:	100845900
SBI:	SORBI_03g008670(SORBIDRAFT_03g008670) SORBI_03g008680(SORBIDRAFT_03g008680)
SMO:	SELMODRAFT_125024 SELMODRAFT_130952
PPP:	PHYPADRAFT_85498
CRE:	CHLREDRAFT_206149(ATM1)
OLU:	OSTLU_51045
OTA:	Ot12g01960
SCE:	YBL088C(TEL1)
AGO:	AGOS_AGL287W
KLA:	KLLA0E06975g
LTH:	KLTH0C06050g
PPA:	PAS_chr1-3_0143
VPO:	Kpol_1045p22
ZRO:	ZYRO0B03982g
CGR:	CAGL0H04609g
NCS:	NCAS_0E02450(NCAS0E02450)
NDI:	NDAI_0E04020(NDAI0E04020)
TPF:	TPHA_0K00690(TPHA0K00690)
TBL:	TBLA_0D00420(TBLA0D00420)
TDL:	TDEL_0C02790(TDEL0C02790)
KAF:	KAFR_0L01900(KAFR0L01900)
DHA:	DEHA2C04752g
PGU:	PGUG_05750
LEL:	LELG_04803
CAL:	CaO19.13026(TEL1) CaO19.5580(TEL1)
CTP:	CTRG_02792
CDU:	CD36_63010
COT:	CORT_0F02830
YLI:	YALI0D03888g
CLU:	CLUG_03791
NCR:	NCU00274
SMP:	SMAC_06685
PAN:	PODANSg5154
TTT:	THITE_2118716
MTM:	MYCTH_115624
FGR:	FG05519.1
NHE:	NECHADRAFT_95538
VAL:	VDBG_06833
SSL:	SS1G_03224
BFU:	BC1G_06772
ANI:	AN0038.2
NFI:	NFIA_074550
AFM:	AFUA_5G12660
AOR:	AOR_1_694094(AO090120000393)
ANG:	ANI_1_1604124(An14g06540)
AFV:	AFLA_093750
ACT:	ACLA_015700
PCS:	Pc21g09040
CIM:	CIMG_09300
CPW:	CPC735_016910
PBL:	PAAG_02532
URE:	UREG_04998
ABE:	ARB_03387
TVE:	TRV_08071
AJE:	HCAG_02557
PNO:	SNOG_10359
PTE:	PTT_08591
ZTR:	MYCGRDRAFT_68352(TOR2)
TML:	GSTUM_00007669001
SPO:	SPCC23B6.03c(tel1)
CNE:	CNF02070
CNB:	CNBF2640
CGI:	CGB_F3720C
LBC:	LACBIDRAFT_188008
MPR:	MPER_04652
CCI:	CC1G_00839
SCM:	SCHCODRAFT_15406
PGR:	PGTG_22077
MBR:	MONBRDRAFT_34416(ATM)
NGR:	NAEGRDRAFT_78079
EHI:	EHI_017670(199.t00007)
EDI:	EDI_100660
TGO:	TGME49_048530
TVA:	TVAG_139170
PTI:	PHATRDRAFT_51040
TPS:	THAPSDRAFT_25187
PIF:	PITG_00828

» show all

Reference

PMID:17457059

Authors

Lavin MF, Kozlov S

Title

ATM activation and DNA damage response.

Journal

Cell Cycle 6:931-42 (2007)

All links

Ontology (7)   
   KEGG BRITE (7)   
Pathway (33)   
   KEGG PATHWAY (12)   
   KEGG MODULE (21)   
Disease (4)   
   KEGG DISEASE (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (288)   
   KEGG GENES (148)   
   KEGG DGENES (13)   
   KEGG EGENES (114)   
   KEGG MGENES (13)   
Protein sequence (115)   
   UniProt (115)   
Literature (1)   
   PubMed (1)   
All databases (449)   

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