KEGG   ORTHOLOGY: K04733Help
Entry
K04733                      KO                                     

Name
IRAK4
Definition
interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
Pathway
MAPK signaling pathway
NF-kappa B signaling pathway
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Toll and Imd signaling pathway
Neurotrophin signaling pathway
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Measles
Influenza A
Module
M00686  
Toll-like receptor signaling
Disease
H00096  
Defects of toll-like receptor signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   04064 NF-kappa B signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   04624 Toll and Imd signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   04621 NOD-like receptor signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
  Nervous system
   04722 Neurotrophin signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
 Human Diseases
  Infectious diseases
   05133 Pertussis
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05152 Tuberculosis
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05162 Measles
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05164 Influenza A
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05145 Toxoplasmosis
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05140 Leishmaniasis
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05142 Chagas disease (American trypanosomiasis)
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00686  Toll-like receptor signaling
     K04733  IRAK4; interleukin-1 receptor-associated kinase 4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04733  IRAK4; interleukin-1 receptor-associated kinase 4
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: TKL group
  IRAK family
   K04733  IRAK4; interleukin-1 receptor-associated kinase 4
BRITE hierarchy
Genes
HSA: 
51135(IRAK4)
PTR: 
466962(IRAK4)
PPS: 
100968191(IRAK4)
GGO: 
101141826(IRAK4)
PON: 
100447243(IRAK4)
NLE: 
100602648(IRAK4)
MCC: 
700568(IRAK4)
MCF: 
102140231(IRAK4)
CSAB: 
103238180(IRAK4)
RRO: 
104677388(IRAK4)
RBB: 
108539989(IRAK4)
CJC: 
100402978(IRAK4)
SBQ: 
101029005(IRAK4)
MMU: 
266632(Irak4)
RNO: 
300177(Irak4)
CGE: 
100751891(Irak4)
NGI: 
103728592(Irak4)
HGL: 
101698190(Irak4)
CCAN: 
OCU: 
100341605(IRAK4)
TUP: 
102490347(IRAK4)
CFA: 
486601(IRAK4)
AML: 
100469127(IRAK4)
UMR: 
103675405(IRAK4)
FCA: 
101100225(IRAK4)
PTG: 
102962570(IRAK4)
AJU: 
106978292(IRAK4)
BTA: 
533692(IRAK4)
BOM: 
102284148(IRAK4)
BIU: 
109559201(IRAK4)
PHD: 
102344444(IRAK4)
CHX: 
102171575(IRAK4)
OAS: 
100216438(IRAK4)
SSC: 
100127166(IRAK4)
CFR: 
102518467(IRAK4)
CDK: 
105097094(IRAK4)
BACU: 
103013107(IRAK4)
LVE: 
103080704(IRAK4)
ECB: 
100054848(IRAK4)
EPZ: 
103547487(IRAK4)
EAI: 
106828056(IRAK4)
MYB: 
102262455(IRAK4)
MYD: 
102754676(IRAK4)
HAI: 
109388403(IRAK4)
RSS: 
109456250(IRAK4)
PALE: 
102880867(IRAK4)
LAV: 
100653528(IRAK4)
MDO: 
100019202(IRAK4)
SHR: 
100934112(IRAK4)
OAA: 
GGA: 
417796(IRAK4)
MGP: 
100538968(IRAK4)
CJO: 
107309789(IRAK4)
APLA: 
101794110(IRAK4)
ACYG: 
106047628(IRAK4)
TGU: 
100227974(IRAK4)
GFR: 
102032992(IRAK4)
FAB: 
101816877(IRAK4)
PHI: 
102100592(IRAK4)
PMAJ: 
107204545(IRAK4)
CCW: 
104698327(IRAK4)
FPG: 
101914647(IRAK4)
FCH: 
102057320(IRAK4)
CLV: 
102092630(IRAK4)
AAM: 
106488895(IRAK4)
ASN: 
102375747(IRAK4)
AMJ: 
102560034(IRAK4)
PSS: 
102445433(IRAK4)
CMY: 
102940314(IRAK4)
CPIC: 
101931311(IRAK4)
ACS: 
100556834(irak4)
PVT: 
110079982(IRAK4)
PBI: 
103053361(IRAK4)
GJA: 
107125917(IRAK4)
XLA: 
108711122(irak4.L)
XTR: 
733738(irak4)
NPR: 
108789468(IRAK4)
DRE: 
393132(irak4)
SRX: 
107710863(irak4)
SANH: 
107695004(irak4)
SGH: 
107564744(irak4)
IPU: 
100528915(irak4)
AMEX: 
103046249(irak4)
TRU: 
101066430(irak4)
TNG: 
LCO: 
104933859(irak4)
NCC: 
104950347(irak4)
MZE: 
101482950(irak4)
OLA: 
101158603(irak4)
XMA: 
102235789(irak4)
CSEM: 
103380353(irak4)
LCF: 
108888551(irak4)
HCQ: 
109529881(irak4)
BPEC: 
110168058(irak4)
SASA: 
100196744(irak4)
ELS: 
105026619(irak4)
SFM: 
108931599(irak4)
LCM: 
102365908(IRAK4)
CMK: 
103186122(irak4)
BFO: 
CIN: 
SPU: 
APLC: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
Dyak_GE25413(Dyak_tub)
DGR: 
DMO: 
DVI: 
Dvir_GJ22964(Dvir_tub)
MDE: 
AGA: 
AAG: 
CQU: 
BIM: 
SOC: 
AEC: 
ACEP: 
HST: 
CFO: 
LHU: 
TCA: 
DPA: 
NVL: 
BMOR: 
DPL: 
PXY: 
API: 
DNX: 
PHU: 
FCD: 
DPX: 
ISC: 
TUT: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
TAD: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Li S, Strelow A, Fontana EJ, Wesche H
  Title
IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.
  Journal
Proc Natl Acad Sci U S A 99:5567-72 (2002)
DOI:10.1073/pnas.082100399
  Sequence
[hsa:51135]

DBGET integrated database retrieval system