KEGG   ORTHOLOGY: K04741Help
Entry
K04741                      KO                                     

Name
CASP12
Definition
caspase 12 [EC:3.4.22.-]
Pathway
Protein processing in endoplasmic reticulum
Apoptosis
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Prion diseases
Hepatitis B
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04741  CASP12; caspase 12
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K04741  CASP12; caspase 12
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K04741  CASP12; caspase 12
   05014 Amyotrophic lateral sclerosis (ALS)
    K04741  CASP12; caspase 12
   05020 Prion diseases
    K04741  CASP12; caspase 12
  Infectious diseases
   05161 Hepatitis B
    K04741  CASP12; caspase 12
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.-  
     K04741  CASP12; caspase 12
Peptidases [BR:ko01002]
 Cysteine Peptidases
  Family C14: caspase family
   K04741  CASP12; caspase 12
BRITE hierarchy
Genes
HSA: 
100506742(CASP12)
PTR: 
466766(CASP12)
PPS: 
100991705(CASP12)
GGO: 
101137790(CASP12)
PON: 
NLE: 
100587073(CASP12)
MCC: 
724039(CASP12)
MCF: 
MMU: 
12364(Casp12)
RNO: 
156117(Casp12)
CGE: 
HGL: 
TUP: 
CFA: 
479458(CASP12)
AML: 
UMR: 
FCA: 
100135767(CASP12)
PTG: 
BACU: 
103011794(CASP12)
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J
  Title
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by  amyloid-beta.
  Journal
Nature 403:98-103 (2000)
Reference
  Authors
Chowdhury I, Tharakan B, Bhat GK
  Title
Caspases - an update.
  Journal
Comp Biochem Physiol B Biochem Mol Biol 151:10-27 (2008)

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