KEGG   ORTHOLOGY: K04850Help
Entry
K04850                      KO                                     

Name
CACNA1C
Definition
voltage-dependent calcium channel L type alpha-1C
Pathway
ko04010  MAPK signaling pathway
ko04020  Calcium signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04260  Cardiac muscle contraction
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04713  Circadian entrainment
ko04720  Long-term potentiation
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04726  Serotonergic synapse
ko04727  GABAergic synapse
ko04728  Dopaminergic synapse
ko04742  Taste transduction
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04921  Oxytocin signaling pathway
ko04924  Renin secretion
ko04925  Aldosterone synthesis and secretion
ko04927  Cortisol synthesis and secretion
ko04930  Type II diabetes mellitus
ko04934  Cushing's syndrome
ko05010  Alzheimer's disease
ko05031  Amphetamine addiction
ko05410  Hypertrophic cardiomyopathy (HCM)
ko05412  Arrhythmogenic right ventricular cardiomyopathy (ARVC)
ko05414  Dilated cardiomyopathy (DCM)
Disease
H00720  Long QT syndrome
H00728  Brugada syndrome (BRS)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
   04020 Calcium signaling pathway
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
   04024 cAMP signaling pathway
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
   04022 cGMP - PKG signaling pathway
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
   04912 GnRH signaling pathway
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
   04921 Oxytocin signaling pathway
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
   04924 Renin secretion
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
   04925 Aldosterone synthesis and secretion
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
   04927 Cortisol synthesis and secretion
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
  Circulatory system
   04260 Cardiac muscle contraction
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
   04261 Adrenergic signaling in cardiomyocytes
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
   04270 Vascular smooth muscle contraction
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
  Nervous system
   04724 Glutamatergic synapse
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
   04727 GABAergic synapse
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
   04725 Cholinergic synapse
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
   04728 Dopaminergic synapse
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
   04726 Serotonergic synapse
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
   04720 Long-term potentiation
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
   04723 Retrograde endocannabinoid signaling
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
  Sensory system
   04742 Taste transduction
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
  Environmental adaptation
   04713 Circadian entrainment
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
  Substance dependence
   05031 Amphetamine addiction
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
   05414 Dilated cardiomyopathy (DCM)
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
   04934 Cushing's syndrome
    K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
Ion channels [BR:ko04040]
 Voltage-gated cation channels
  Ca2+ channel, CACN alpha-1, CaVx.x
   K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
BRITE hierarchy
Other DBs
GO: 0005245
TC: 1.A.1.11.4 1.A.1.11.6
Genes
HSA: 775(CACNA1C)
PTR: 466915(CACNA1C)
PPS: 100971701(CACNA1C)
GGO: 101134060(CACNA1C)
PON: 100442085(CACNA1C)
NLE: 100580437(CACNA1C)
MCC: 721721(CACNA1C)
MCF: 101865175
CSAB: 103218385(CACNA1C)
RRO: 104659017
RBB: 108522695(CACNA1C)
CJC: 100406735(CACNA1C)
SBQ: 101040048(CACNA1C)
MMU: 12288(Cacna1c)
RNO: 24239(Cacna1c)
CGE: 100754788(Cacna1c)
NGI: 103739378(Cacna1c)
HGL: 101717129(Cacna1c)
OCU: 100101555(CACNA1C)
TUP: 102489611
CFA: 403516(CACNA1C)
AML: 100479715(CACNA1C)
UMR: 103675706(CACNA1C)
ORO: 101365624(CACNA1C)
FCA: 101082923(CACNA1C)
PTG: 102956322(CACNA1C)
AJU: 106965473(CACNA1C)
BTA: 408015(CACNA1C)
BOM: 102277590(CACNA1C)
BIU: 109558615(CACNA1C)
PHD: 102319156(CACNA1C)
CHX: 100861292(CACNA1C)
OAS: 101116562(CACNA1C)
SSC: 100518733(CACNA1C)
CFR: 102524149(CACNA1C)
CDK: 105100748
BACU: 103019389(CACNA1C)
LVE: 103087340(CACNA1C)
OOR: 101272740(CACNA1C)
ECB: 100049924(CACNA1C)
EPZ: 103541004 103563810(CACNA1C)
EAI: 106839455(CACNA1C)
MYB: 102240225(CACNA1C)
MYD: 102753812(CACNA1C)
HAI: 109388950(CACNA1C)
RSS: 109461209(CACNA1C)
PALE: 102882682(CACNA1C)
TMU: 101360945
MDO: 100021421(CACNA1C)
SHR: 100926503(CACNA1C)
GGA: 395891(CACNA1C)
MGP: 100547459(CACNA1C)
CJO: 107315213(CACNA1C)
APLA: 101790062(CACNA1C)
ACYG: 106030933(CACNA1C)
TGU: 100218244(CACNA1C)
GFR: 102031898
FAB: 101815051(CACNA1C)
PHI: 102106069(CACNA1C)
PMAJ: 107204397(CACNA1C)
CCW: 104692245(CACNA1C)
FPG: 101916694(CACNA1C)
FCH: 102048150(CACNA1C)
CLV: 102095010(CACNA1C)
EGZ: 104134399(CACNA1C)
AAM: 106488364(CACNA1C)
ASN: 102377475(CACNA1C)
AMJ: 102575519(CACNA1C)
PSS: 102451554(CACNA1C)
CMY: 102940198(CACNA1C)
CPIC: 101946823(CACNA1C)
ACS: 100553244(cacna1c)
PVT: 110076659(CACNA1C)
PBI: 103062045(CACNA1C)
GJA: 107120231(CACNA1C)
XLA: 100462911(cacna1c.S) 108704565
XTR: 100488055(cacna1c)
NPR: 108791575
DRE: 170581(cacna1c)
IPU: 108279829
AMEX: 103041474
TRU: 101064574
LCO: 104940547(cacna1c)
MZE: 101471946(cacna1c)
OLA: 101173517
XMA: 102230290(cacna1c)
PRET: 103459268
NFU: 107385235(cacna1c)
CSEM: 103382787(cacna1c)
LCF: 108879625
HCQ: 109520063
BPEC: 110162494
ELS: 105023097
SFM: 108920904(cacna1c)
LCM: 102357941(CACNA1C)
CMK: 103179419
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Tiwari S, Zhang Y, Heller J, Abernethy DR, Soldatov NM
  Title
Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel alpha1C subunit.
  Journal
Proc Natl Acad Sci U S A 103:17024-9 (2006)
DOI:10.1073/pnas.0606539103
  Sequence
[hsa:775]
Reference
PMID:1316612
  Authors
Soldatov NM
  Title
Molecular diversity of L-type Ca2+ channel transcripts in human fibroblasts.
  Journal
Proc Natl Acad Sci U S A 89:4628-32 (1992)
  Sequence
[hsa:775]

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