KEGG   ORTHOLOGY: K05070Help
Entry
K05070                      KO                                     

Name
IL2RG, CD132
Definition
interleukin 2 receptor gamma
Pathway
ko04060  Cytokine-cytokine receptor interaction
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04630  Jak-STAT signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko05162  Measles
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05321  Inflammatory bowel disease (IBD)
ko05340  Primary immunodeficiency
Disease
H00091  T-B+Severe combined immunodeficiencies (SCIDs)
H00093  Combined immunodeficiencies (CIDs)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   04151 PI3K-Akt signaling pathway
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
 Organismal Systems
  Immune system
   04658 Th1 and Th2 cell differentiation
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   04659 Th17 cell differentiation
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
  Immune diseases
   05321 Inflammatiory bowel disease (IBD)
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   05340 Primary immunodeficiency
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
  Infectious diseases
   05166 HTLV-I infection
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   05162 Measles
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
Cytokine receptors [BR:ko04050]
 Interleukin receptor families
  IL2 receptor family
   K05070  IL2RG, CD132; interleukin 2 receptor gamma
CD molecules [BR:ko04090]
 Proteins
  K05070  CD132, IL2RG; interleukin 2 receptor, gamma (severe combined immunodeficiency)
BRITE hierarchy
Other DBs
GO: 0004911
Genes
HSA: 3561(IL2RG)
PTR: 101059843(IL2RG)
PPS: 100986679(IL2RG)
GGO: 101134845(IL2RG)
PON: 100454903(IL2RG)
NLE: 100585758(IL2RG)
MCC: 641338(IL2RG)
MCF: 102144912(IL2RG)
CSAB: 103232148(IL2RG)
RRO: 104656782(IL2RG)
RBB: 108532108(IL2RG)
CJC: 100388189(IL2RG)
SBQ: 101047979(IL2RG)
MMU: 16186(Il2rg)
RNO: 140924(Il2rg)
CGE: 100756284(Il2rg)
NGI: 103751955(Il2rg)
HGL: 101715243(Il2rg)
CCAN: 109673990(Il2rg)
OCU: 103351862(IL2RG)
TUP: 102476004(IL2RG)
CFA: 403851(IL2RG)
AML: 100468126(IL2RG)
UMR: 103682591(IL2RG)
ORO: 101374379(IL2RG)
FCA: 101090239(IL2RG)
PTG: 102966580(IL2RG)
AJU: 106982399(IL2RG)
BTA: 281862(IL2RG)
BOM: 102266681(IL2RG)
BIU: 109555190(IL2RG)
PHD: 102319279(IL2RG)
CHX: 102169656(IL2RG)
OAS: 101103538(IL2RG)
SSC: 397156(IL2RG)
CFR: 102518550(IL2RG)
CDK: 105087982(IL2RG)
BACU: 103016442(IL2RG)
LVE: 103087530(IL2RG)
OOR: 101286718(IL2RG)
ECB: 100055911(IL2RG)
EPZ: 103544610(IL2RG)
EAI: 106828880(IL2RG)
MYB: 102241164(IL2RG)
MYD: 102757155(IL2RG)
HAI: 109385585(IL2RG)
RSS: 109455963(IL2RG)
PALE: 102888070(IL2RG)
LAV: 100664834(IL2RG)
TMU: 101359472
MDO: 100619507(IL2RG)
SHR: 100929781(IL2RG)
GGA: 395199(IL2RG)
MGP: 104912104(IL2RG)
CJO: 107312576(IL2RG)
APLA: 101794194(IL2RG)
ACYG: 106037383(IL2RG)
TGU: 100226174(IL2RG)
GFR: 102043888(IL2RG)
FAB: 107603321(IL2RG)
PHI: 102112500(IL2RG)
PMAJ: 107203656(IL2RG)
CCW: 104691748(IL2RG)
FPG: 101923008(IL2RG)
FCH: 102052025(IL2RG)
CLV: 102094834(IL2RG)
EGZ: 104124289(IL2RG)
ASN: 102379602(IL2RG)
AMJ: 102575498(IL2RG)
PSS: 102443813(IL2RG)
CMY: 102933244(IL2RG)
CPIC: 101931356(IL2RG)
ACS: 103281066(il2rg)
PVT: 110080214(IL2RG)
PBI: 103061889(IL2RG)
GJA: 107108490(IL2RG)
XLA: 100036958(il2rg.L)
XTR: 100492995(il2rg)
NPR: 108800627(IL2RG)
DRE: 100144554(il2rgb) 796604(il2rga)
IPU: 108269358(il2rg) 108276805
TRU: 100190946(il2rg)
LCO: 104938889(il2rg)
OLA: 101156347
XMA: 102230559
PRET: 103475386
NFU: 107386732
CSEM: 103395485(il2rg)
HCQ: 109512452
LCM: 102356230(IL2RG)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1631559
  Authors
Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, Munakata H, Nakamura M, Sugamura K
  Title
Cloning of the gamma chain of the human IL-2 receptor.
  Journal
Science 257:379-82 (1992)
DOI:10.1126/science.1631559
  Sequence
[hsa:3561]
Reference
PMID:8476561
  Authors
Minami Y, Kono T, Miyazaki T, Taniguchi T
  Title
The IL-2 receptor complex: its structure, function, and target genes.
  Journal
Annu Rev Immunol 11:245-68 (1993)
DOI:10.1146/annurev.iy.11.040193.001333
Reference
  Authors
Zhang Q, Wang HY, Liu X, Bhutani G, Kantekure K, Wasik M
  Title
IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK.
  Journal
Proc Natl Acad Sci U S A 108:11977-82 (2011)
DOI:10.1073/pnas.1100319108
  Sequence
[hsa:3561]

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