KEGG   ORTHOLOGY: K05071Help
Entry
K05071                      KO                                     

Name
IL4R, CD124
Definition
interleukin 4 receptor
Pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
Th1 and Th2 cell differentiation
Th17 cell differentiation
Pathways in cancer
Inflammatory bowel disease (IBD)
Disease
H00079  
Asthma
H01358  
Atopic dermatitis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K05071  IL4R, CD124; interleukin 4 receptor
   04151 PI3K-Akt signaling pathway
    K05071  IL4R, CD124; interleukin 4 receptor
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05071  IL4R, CD124; interleukin 4 receptor
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K05071  IL4R, CD124; interleukin 4 receptor
   04658 Th1 and Th2 cell differentiation
    K05071  IL4R, CD124; interleukin 4 receptor
   04659 Th17 cell differentiation
    K05071  IL4R, CD124; interleukin 4 receptor
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05071  IL4R, CD124; interleukin 4 receptor
  Immune diseases
   05321 Inflammatiory bowel disease (IBD)
    K05071  IL4R, CD124; interleukin 4 receptor
Cytokine receptors [BR:ko04050]
 Class I cytokine receptor (hematopoietin family receptor)
  K05071  IL4R, CD124; interleukin 4 receptor
CD molecules [BR:ko04090]
 Proteins
  K05071  CD124, IL4R; interleukin 4 receptor
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
3566(IL4R)
PTR: 
454005(IL4R)
PPS: 
100969808(IL4R)
GGO: 
101124934(IL4R)
PON: 
100449812(IL4R)
NLE: 
100606206(IL4R)
MCC: 
705404(IL4R)
MCF: 
102133649(IL4R)
CSAB: 
103230069(IL4R)
RRO: 
104665638(IL4R)
RBB: 
108538856(IL4R)
CJC: 
100412639(IL4R)
SBQ: 
101044733(IL4R)
MMU: 
16190(Il4ra)
RNO: 
25084(Il4r)
CGE: 
100762840(Il4r)
NGI: 
103741011(Il4r)
HGL: 
101704138(Il4r)
CCAN: 
109698033(Il4r)
OCU: 
100337721(IL4R)
TUP: 
102469844(IL4R)
CFA: 
489957(IL4R)
AML: 
100476095(IL4R)
UMR: 
103657902(IL4R)
FCA: 
101096277(IL4R)
PTG: 
102949893(IL4R)
AJU: 
106966182(IL4R)
BTA: 
404154(IL4R)
BOM: 
102273764(IL4R)
BIU: 
109578521(IL4R)
PHD: 
102337351(IL4R)
CHX: 
102176382(IL4R)
OAS: 
101109063(IL4R)
SSC: 
397614(IL4R)
CFR: 
102504937(IL4R)
CDK: 
105098257(IL4R)
BACU: 
103017383(IL4R)
LVE: 
103085500(IL4R)
ECB: 
791252(IL4R)
EPZ: 
103556347(IL4R)
EAI: 
106829083(IL4R)
MYB: 
MYD: 
HAI: 
109385965(IL4R)
RSS: 
109438291(IL4R)
PALE: 
102882815(IL4R)
LAV: 
100654822(IL4R)
MDO: 
103092514(IL4R)
SHR: 
100922104(IL4R)
OAA: 
GGA: 
416585(IL4R)
MGP: 
100541265(IL4R)
CJO: 
107320714(IL4R)
APLA: 
101796552(IL4R)
ACYG: 
106046042(IL4R)
TGU: 
100220266(IL4R)
GFR: 
102032458(IL4R)
FAB: 
101812385(IL4R)
PHI: 
102114232(IL4R)
PMAJ: 
107211179(IL4R)
CCW: 
104684903(IL4R)
FPG: 
101913747(IL4R)
FCH: 
102059925(IL4R)
CLV: 
102092650(IL4R)
AAM: 
106486134(IL4R)
ASN: 
102384900(IL4R)
AMJ: 
102563749(IL4R)
PSS: 
102459395(IL4R)
CMY: 
102929479(IL4R)
CPIC: 
101942260(IL4R)
ACS: 
103281083(il4r)
PVT: 
PBI: 
103065038(IL4R)
XLA: 
XTR: 
DRE: 
563674(il4r.2)
SRX: 
SANH: 
SGH: 
IPU: 
SASA: 
ELS: 
105013235(il4r)
SFM: 
LCM: 
CMK: 
103186635(il4r)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2307934
  Authors
Idzerda RL, March CJ, Mosley B, Lyman SD, Vanden Bos T, Gimpel SD, Din WS, Grabstein KH, Widmer MB, Park LS, et al.
  Title
Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily.
  Journal
J Exp Med 171:861-73 (1990)
DOI:10.1084/jem.171.3.861
  Sequence
[hsa:3566]
Reference
PMID:8124718
  Authors
Keegan AD, Nelms K, White M, Wang LM, Pierce JH, Paul WE
  Title
An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth.
  Journal
Cell 76:811-20 (1994)
DOI:10.1016/0092-8674(94)90356-5

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