KEGG   ORTHOLOGY: K05082Help
Entry
K05082                      KO                                     

Name
TPOR, MPL, CD110
Definition
thrombopoietin receptor
Pathway
Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Disease
H00227  
Congenital amegakaryocytic thrombocytopenia (CAMT)
H01605  
Myelofibrosis
H01612  
Essential thrombocytosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K05082  TPOR, MPL, CD110; thrombopoietin receptor
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05082  TPOR, MPL, CD110; thrombopoietin receptor
Cytokine receptors [BR:ko04050]
 Class I cytokine receptor (hematopoietin family receptor)
  K05082  TPOR, MPL, CD110; thrombopoietin receptor
Cellular antigens [BR:ko04090]
 Proteins
  K05082  CD110, MPL; myeloproliferative leukemia virus oncogene
BRITE hierarchy
Genes
HSA: 
4352(MPL)
PTR: 
747522(MPL)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
723813(MPL)
MCF: 
CSAB: 
RRO: 
CJC: 
SBQ: 
MMU: 
17480(Mpl)
RNO: 
366455(Mpl)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
610801(MPL)
AML: 
UMR: 
FCA: 
PTG: 
BTA: 
528492(MPL)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
LAV: 
OAA: 
GGA: 
414804(MPL)
MGP: 
CJO: 
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
CMY: 
ACS: 
PBI: 
GJA: 
XTR: 
DRE: 
445381(mpl)
TRU: 
MZE: 
OLA: 
XMA: 
SASA: 
106560515(TPOR) 106584017(TPOR)
LCM: 
CMK: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1608974
  Authors
Vigon I, Mornon JP, Cocault L, Mitjavila MT, Tambourin P, Gisselbrecht S, Souyri M
  Title
Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor  superfamily.
  Journal
Proc Natl Acad Sci U S A 89:5640-4 (1992)
  Sequence
[hsa:4352]
Reference
  Authors
Matthews EE, Thevenin D, Rogers JM, Gotow L, Lira PD, Reiter LA, Brissette WH, Engelman DM
  Title
Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation.
  Journal
FASEB J 25:2234-44 (2011)

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