KEGG   ORTHOLOGY: K05087Help
Entry
K05087                      KO                                     

Name
IGF1R
Definition
insulin-like growth factor 1 receptor [EC:2.7.10.1]
Pathway
Ras signaling pathway
Rap1 signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
Endocytosis
PI3K-Akt signaling pathway
AMPK signaling pathway
Focal adhesion
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Long-term depression
Ovarian steroidogenesis
Progesterone-mediated oocyte maturation
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
Glioma
Prostate cancer
Melanoma
Disease
H00015  
Malignant pleural mesothelioma
H00050  
Synovial sarcoma
H01274  
Growth delay due to insulin-like growth factor I resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05087  IGF1R; insulin-like growth factor 1 receptor
   04015 Rap1 signaling pathway
    K05087  IGF1R; insulin-like growth factor 1 receptor
   04066 HIF-1 signaling pathway
    K05087  IGF1R; insulin-like growth factor 1 receptor
   04068 FoxO signaling pathway
    K05087  IGF1R; insulin-like growth factor 1 receptor
   04151 PI3K-Akt signaling pathway
    K05087  IGF1R; insulin-like growth factor 1 receptor
   04152 AMPK signaling pathway
    K05087  IGF1R; insulin-like growth factor 1 receptor
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K05087  IGF1R; insulin-like growth factor 1 receptor
  Cell growth and death
   04114 Oocyte meiosis
    K05087  IGF1R; insulin-like growth factor 1 receptor
  Cellular commiunity
   04510 Focal adhesion
    K05087  IGF1R; insulin-like growth factor 1 receptor
   04520 Adherens junction
    K05087  IGF1R; insulin-like growth factor 1 receptor
   04550 Signaling pathways regulating pluripotency of stem cells
    K05087  IGF1R; insulin-like growth factor 1 receptor
 Organismal Systems
  Endocrine system
   04913 Ovarian Steroidogenesis
    K05087  IGF1R; insulin-like growth factor 1 receptor
   04914 Progesterone-mediated oocyte maturation
    K05087  IGF1R; insulin-like growth factor 1 receptor
  Nervous system
   04730 Long-term depression
    K05087  IGF1R; insulin-like growth factor 1 receptor
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05087  IGF1R; insulin-like growth factor 1 receptor
   05202 Transcriptional misregulation in cancers
    K05087  IGF1R; insulin-like growth factor 1 receptor
   05205 Proteoglycans in cancer
    K05087  IGF1R; insulin-like growth factor 1 receptor
   05214 Glioma
    K05087  IGF1R; insulin-like growth factor 1 receptor
   05218 Melanoma
    K05087  IGF1R; insulin-like growth factor 1 receptor
   05215 Prostate cancer
    K05087  IGF1R; insulin-like growth factor 1 receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05087  IGF1R; insulin-like growth factor 1 receptor
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  InsR family [OT]
   K05087  IGF1R; insulin-like growth factor 1 receptor
Enzyme-linked receptors [BR:ko01020]
 Receptor tyrosine kinases
  RTK class II (Insulin receptor family)
   K05087  IGF1R; insulin-like growth factor 1 receptor
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class II (Insulin receptor family)
   K05087  IGF1R; insulin-like growth factor 1 receptor
Cellular antigens [BR:ko04090]
 Proteins
  K05087  CD221, IGF1R; insulin-like growth factor 1 receptor
BRITE hierarchy
Other DBs
Genes
HSA: 
3480(IGF1R)
PTR: 
453676(IGF1R)
PPS: 
100981083(IGF1R)
GGO: 
101154546(IGF1R)
PON: 
100172156(IGF1R)
MCC: 
708227(IGF1R)
MCF: 
102130142(IGF1R)
MMU: 
16001(Igf1r)
RNO: 
25718(Igf1r)
CGE: 
100768531(Igf1r)
HGL: 
101710224(Igf1r)
TUP: 
CFA: 
442951(IGF1R)
AML: 
100471374(IGF1R)
FCA: 
PTG: 
BTA: 
281848(IGF1R)
BOM: 
102278105(IGF1R)
PHD: 
102324754(IGF1R)
CHX: 
100861165(IGF-IR)
OAS: 
443515(IGFR1)
SSC: 
397350(IGF1R)
CFR: 
102524338(IGF1R)
BACU: 
103015537(IGF1R)
LVE: 
103081291(IGF1R)
ECB: 
100055698(IGF1R)
MYB: 
MYD: 
102770795(IGF1R)
PALE: 
102885962(IGF1R)
MDO: 
100020095(IGF1R)
SHR: 
100916673(IGF1R)
OAA: 
100077556(IGF1R)
GGA: 
395889(IGF1R)
MGP: 
100539720(IGF1R)
TGU: 
100227374(IGF1R)
FAB: 
101819893(IGF1R)
PHI: 
102103364(IGF1R)
APLA: 
101802018(IGF1R)
FPG: 
101914715(IGF1R)
FCH: 
102046128(IGF1R)
CLV: 
102089963(IGF1R)
ASN: 
102387852(IGF1R)
AMJ: 
102576524(IGF1R)
PSS: 
102455576(IGF1R)
CMY: 
102941686(IGF1R)
ACS: 
100554064(igf1r)
PBI: 
103049336(IGF1R)
XLA: 
398022(igf1r)
XTR: 
100329112(igf1r)
DRE: 
245701(igf1ra) 245702(igf1rb)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102367342(IGF1R)
CMK: 
103188389(igf1r)
ISC: 
LOA: 
TSP: 
HMG: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Siddle K, Urso B, Niesler CA, Cope DL, Molina L, Surinya KH, Soos MA
  Title
Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors.
  Journal
Biochem Soc Trans 29:513-25 (2001)

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