KEGG   ORTHOLOGY: K05089Help
Entry
K05089                      KO                                     

Name
PDGFRB
Definition
platelet-derived growth factor receptor beta [EC:2.7.10.1]
Pathway
EGFR tyrosine kinase inhibitor resistance
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
Phospholipase D signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
Regulation of actin cytoskeleton
HTLV-I infection
Pathways in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Melanoma
Central carbon metabolism in cancer
Choline metabolism in cancer
Disease
H00042  
Glioma
H01574  
Familial idiopathic basal ganglia calcification
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05089  PDGFRB; platelet-derived growth factor receptor beta
   04015 Rap1 signaling pathway
    K05089  PDGFRB; platelet-derived growth factor receptor beta
   04010 MAPK signaling pathway
    K05089  PDGFRB; platelet-derived growth factor receptor beta
   04020 Calcium signaling pathway
    K05089  PDGFRB; platelet-derived growth factor receptor beta
   04072 Phospholipase D signaling pathway
    K05089  PDGFRB; platelet-derived growth factor receptor beta
   04151 PI3K-Akt signaling pathway
    K05089  PDGFRB; platelet-derived growth factor receptor beta
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05089  PDGFRB; platelet-derived growth factor receptor beta
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K05089  PDGFRB; platelet-derived growth factor receptor beta
  Cellular community
   04510 Focal adhesion
    K05089  PDGFRB; platelet-derived growth factor receptor beta
   04540 Gap junction
    K05089  PDGFRB; platelet-derived growth factor receptor beta
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05089  PDGFRB; platelet-derived growth factor receptor beta
   05230 Central carbon metabolism in cancer
    K05089  PDGFRB; platelet-derived growth factor receptor beta
   05231 Choline metabolism in cancer
    K05089  PDGFRB; platelet-derived growth factor receptor beta
   05206 MicroRNAs in cancer
    K05089  PDGFRB; platelet-derived growth factor receptor beta
   05214 Glioma
    K05089  PDGFRB; platelet-derived growth factor receptor beta
   05218 Melanoma
    K05089  PDGFRB; platelet-derived growth factor receptor beta
   05215 Prostate cancer
    K05089  PDGFRB; platelet-derived growth factor receptor beta
  Infectious diseases
   05166 HTLV-I infection
    K05089  PDGFRB; platelet-derived growth factor receptor beta
  Antineoplastic resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05089  PDGFRB; platelet-derived growth factor receptor beta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05089  PDGFRB; platelet-derived growth factor receptor beta
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  PDGFR family [OT]
   K05089  PDGFRB; platelet-derived growth factor receptor beta
Enzyme-linked receptors [BR:ko01020]
 Receptor tyrosine kinases
  RTK class III (PDGF receptor family)
   K05089  PDGFRB; platelet-derived growth factor receptor beta
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class III (PDGF receptor family)
   K05089  PDGFRB; platelet-derived growth factor receptor beta
Cellular antigens [BR:ko04090]
 Proteins
  K05089  CD140b, PDGFRB; platelet-derived growth factor receptor, beta polypeptide
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
5159(PDGFRB)
PTR: 
462188(PDGFRB)
PPS: 
100975853(PDGFRB)
GGO: 
101150577(PDGFRB)
PON: 
100460001(PDGFRB)
NLE: 
100597894(PDGFRB)
MCC: 
711353(PDGFRB)
MCF: 
101867161(PDGFRB)
CSAB: 
103244790(PDGFRB)
RRO: 
104670408(PDGFRB)
CJC: 
100389852(PDGFRB)
SBQ: 
101040158(PDGFRB)
MMU: 
18596(Pdgfrb)
RNO: 
24629(Pdgfrb)
CGE: 
100764374(Pdgfrb)
NGI: 
103747076(Pdgfrb)
HGL: 
101721151(Pdgfrb)
OCU: 
100342872(PDGFRB)
TUP: 
102492413(PDGFRB)
CFA: 
442985(PDGFRB)
AML: 
100472005(PDGFRB)
UMR: 
103664600(PDGFRB)
FCA: 
101084600(PDGFRB)
PTG: 
102954207(PDGFRB)
BTA: 
527165(PDGFRB)
BOM: 
102270608(PDGFRB)
PHD: 
102333941(PDGFRB)
CHX: 
102184426(PDGFRB)
OAS: 
101122783(PDGFRB)
SSC: 
100126842(PDGFRB)
CFR: 
102512951(PDGFRB)
BACU: 
103019883(PDGFRB)
LVE: 
103082363(PDGFRB)
ECB: 
100071665(PDGFRB)
MYB: 
102241145(PDGFRB)
MYD: 
102764172(PDGFRB)
PALE: 
102887643(PDGFRB)
LAV: 
100671240(PDGFRB)
MDO: 
100028943(PDGFRB)
SHR: 
100917212(PDGFRB)
OAA: 
100079459(PDGFRB)
GGA: 
770488(PDGFRB)
MGP: 
100550611(PDGFRB)
CJO: 
107320191(PDGFRB)
APLA: 
101799587(PDGFRB)
TGU: 
100223375(PDGFRB)
GFR: 
102045343(PDGFRB)
FAB: 
101809926(PDGFRB)
PHI: 
102111524(PDGFRB)
CCW: 
104689579(PDGFRB)
FPG: 
101918438(PDGFRB)
FCH: 
102052718(PDGFRB)
CLV: 
102096790(PDGFRB)
AAM: 
106493441(PDGFRB)
ASN: 
102372962(PDGFRB)
AMJ: 
102566175(PDGFRB)
PSS: 
102460895(PDGFRB)
CMY: 
102944650(PDGFRB)
ACS: 
100555784(pdgfrb)
PBI: 
103051588(PDGFRB)
GJA: 
XTR: 
100487523(pdgfrb)
DRE: 
559529(pdgfrb)
TRU: 
101061130 101074724(PDGFR-beta)
TNG: 
MZE: 
101466822(pdgfrb) 101484671(pdgfrb)
OLA: 
XMA: 
SASA: 
LCM: 
102361386(PDGFRB)
CMK: 
103188232(pdgfrb)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Jones AV, Cross NC
  Title
Oncogenic derivatives of platelet-derived growth factor receptors.
  Journal
Cell Mol Life Sci 61:2912-23 (2004)
Reference
PMID:2835772
  Authors
Gronwald RG, Grant FJ, Haldeman BA, Hart CE, O'Hara PJ, Hagen FS, Ross R, Bowen-Pope DF, Murray MJ
  Title
Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.
  Journal
Proc Natl Acad Sci U S A 85:3435-9 (1988)
  Sequence
[hsa:5159]

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