KEGG   ORTHOLOGY: K05090Help
Entry
K05090                      KO                                     

Name
CSF1R, FMS, CD115
Definition
macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
Pathway
Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Osteoclast differentiation
Hematopoietic cell lineage
Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Disease
H00028  
Choriocarcinoma
H01807  
Hereditary diffuse leukoencephalopathy with spheroids
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
   04015 Rap1 signaling pathway
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
   04151 PI3K-Akt signaling pathway
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
  Development
   04380 Osteoclast differentiation
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
   05202 Transcriptional misregulation in cancers
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
   05221 Acute myeloid leukemia
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  PDGFR family [OT]
   K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
Enzyme-linked receptors [BR:ko01020]
 Receptor tyrosine kinases
  RTK class III (PDGF receptor family)
   K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class III (PDGF receptor family)
   K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
CD molecules [BR:ko04090]
 Proteins
  K05090  CD115, CSF1R; colony stimulating factor 1 receptor
BRITE hierarchy
Genes
HSA: 
1436(CSF1R)
PTR: 
462187(CSF1R)
PPS: 
100974967(CSF1R)
GGO: 
101151662(CSF1R)
PON: 
100433386(CSF1R)
NLE: 
100598906(CSF1R)
MCC: 
711512(CSF1R)
MCF: 
102124214(CSF1R)
CSAB: 
103244788(CSF1R)
RRO: 
104670407(CSF1R)
RBB: 
108532049(CSF1R)
CJC: 
100406047(CSF1R)
SBQ: 
101043573(CSF1R)
MMU: 
12978(Csf1r)
RNO: 
307403(Csf1r)
CGE: 
100763221(Csf1r)
NGI: 
103747075(Csf1r)
HGL: 
101719513(Csf1r)
CCAN: 
OCU: 
100340992(CSF1R)
TUP: 
102491581(CSF1R)
CFA: 
489188(CSF1R)
AML: 
100472252(CSF1R)
UMR: 
103664603(CSF1R)
FCA: 
493706(CSF1R)
PTG: 
102953056(CSF1R)
AJU: 
106985394(CSF1R)
BTA: 
509418(CSF1R)
BOM: 
102272280(CSF1R)
BIU: 
109562194(CSF1R)
PHD: 
102334299(CSF1R)
CHX: 
100861303(CSF1R)
OAS: 
101109969(CSF1R)
SSC: 
100517086(CSF1R)
CFR: 
102513202(CSF1R)
CDK: 
105098488(CSF1R)
BACU: 
102999126(CSF1R)
LVE: 
103075680(CSF1R)
ECB: 
100060422(CSF1R)
EPZ: 
EAI: 
106838490(CSF1R)
MYB: 
102256301(CSF1R)
MYD: 
102763897(CSF1R)
HAI: 
109374995(CSF1R)
RSS: 
109448724(CSF1R)
PALE: 
102886964(CSF1R)
LAV: 
100670956(CSF1R)
MDO: 
100028926(CSF1R)
SHR: 
100916950(CSF1R)
OAA: 
100079755(CSF1R)
GGA: 
396406(CSF1R)
MGP: 
100549842(CSF1R)
CJO: 
107320150(CSF1R)
APLA: 
ACYG: 
106032822(CSF1R)
TGU: 
100220482(CSF1R)
GFR: 
102045177(CSF1R)
FAB: 
101809748(CSF1R)
PHI: 
102111338(CSF1R)
PMAJ: 
107210711(CSF1R)
CCW: 
104689582(CSF1R)
FPG: 
101918260(CSF1R)
FCH: 
102052893(CSF1R)
CLV: 
102090039(CSF1R)
AAM: 
106493440(CSF1R)
ASN: 
102373216(CSF1R)
AMJ: 
102565932(CSF1R)
PSS: 
102460494(CSF1R)
CMY: 
102937993(CSF1R)
CPIC: 
101940831(CSF1R)
ACS: 
100555979(csf1r)
PVT: 
110086091(CSF1R)
PBI: 
103051818(CSF1R)
GJA: 
107116323(CSF1R)
XLA: 
101243554(csf1r)
XTR: 
493543(csf1r)
NPR: 
108785796(CSF1R)
DRE: 
568405(csf1rb) 64274(csf1ra)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
101069994(csf1r1) 101080143(csf1r2)
TNG: 
LCO: 
NCC: 
104965699(csf1r)
MZE: 
OLA: 
101157786(csf1r)
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102349790(CSF1R)
CMK: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2421165
  Authors
Coussens L, Van Beveren C, Smith D, Chen E, Mitchell RL, Isacke CM, Verma IM, Ullrich A
  Title
Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus.
  Journal
Nature 320:277-80 (1986)
DOI:10.1038/320277a0
  Sequence
[hsa:1436]
Reference
PMID:9262961
  Authors
Fixe P, Praloran V
  Title
Macrophage colony-stimulating-factor (M-CSF or CSF-1) and its receptor: structure-function relationships.
  Journal
Eur Cytokine Netw 8:125-36 (1997)

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