KEGG   ORTHOLOGY: K05091Help
Entry
K05091                      KO                                     

Name
KIT, SCFR
Definition
proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
Pathway
Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Phospholipase D signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Hematopoietic cell lineage
Melanogenesis
Pathways in cancer
Acute myeloid leukemia
Central carbon metabolism in cancer
Disease
H00003  
Acute myeloid leukemia (AML)
H00170  
Piebaldism
H01359  
Anaphylaxis
H01511  
Mast-cell leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
   04015 Rap1 signaling pathway
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
   04072 Phospholipase D signaling pathway
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
   04151 PI3K-Akt signaling pathway
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
  Endocrine system
   04916 Melanogenesis
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
   05230 Central carbon metabolism in cancer
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
   05221 Acute myeloid leukemia
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  PDGFR family [OT]
   K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
Enzyme-linked receptors [BR:ko01020]
 Receptor tyrosine kinases
  RTK class III (PDGF receptor family)
   K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class III (PDGF receptor family)
   K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
Cellular antigens [BR:ko04090]
 Proteins
  K05091  CD117, KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
BRITE hierarchy
Genes
HSA: 
3815(KIT)
PTR: 
461316(KIT)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
696759(KIT)
MCF: 
RRO: 
CJC: 
MMU: 
16590(Kit)
RNO: 
64030(Kit)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
403811(KIT)
AML: 
UMR: 
FCA: 
493766(KIT)
PTG: 
BTA: 
280832(KIT)
BOM: 
PHD: 
CHX: 
OAS: 
780504(KIT)
SSC: 
396810(KIT)
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
378783(KIT)
MGP: 
APLA: 
TGU: 
GFR: 
FAB: 
PHI: 
CCW: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
373579(kit-a) 373772(kit-b)
XTR: 
DRE: 
30256(kita) 497629(kitb)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wiesmann C, Muller YA, de Vos AM.
  Title
Ligand-binding sites in Ig-like domains of receptor tyrosine kinases.
  Journal
J Mol Med 78:247-60 (2000)
Reference
  Authors
Roskoski R Jr
  Title
Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptor.
  Journal
Biochem Biophys Res Commun 338:1307-15 (2005)
Reference
PMID:1698611
  Authors
Nocka K, Buck J, Levi E, Besmer P
  Title
Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors.
  Journal
EMBO J 9:3287-94 (1990)
  Sequence
[mmu:16590]

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