KEGG   ORTHOLOGY: K05091Help
Entry
K05091                      KO                                     

Name
KIT, SCFR, CD117
Definition
proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04640  Hematopoietic cell lineage
ko04916  Melanogenesis
ko05200  Pathways in cancer
ko05221  Acute myeloid leukemia
ko05224  Breast cancer
ko05230  Central carbon metabolism in cancer
Disease
H00003  Acute myeloid leukemia (AML)
H00031  Breast cancer
H00170  Piebaldism
H01359  Anaphylaxis
H01511  Mast-cell leukemia
H01591  Gastrotintestinal stromal tumor
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   04015 Rap1 signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   04010 MAPK signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   04072 Phospholipase D signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   04151 PI3K-Akt signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
  Endocrine system
   04916 Melanogenesis
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   05230 Central carbon metabolism in cancer
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   05221 Acute myeloid leukemia
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   05224 Breast cancer
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
CD molecules [BR:ko04090]
 Proteins
  K05091  CD117, KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
BRITE hierarchy
Genes
HSA: 3815(KIT)
PTR: 461316(KIT)
PPS: 100985935(KIT)
GGO: 101126389(KIT)
PON: 100437110(KIT)
NLE: 100603893(KIT)
MCC: 696759(KIT)
MCF: 102137242(KIT)
CSAB: 103235672(KIT)
RRO: 104658855(KIT)
RBB: 108533749(KIT)
CJC: 100411615(KIT)
SBQ: 101037282(KIT)
MMU: 16590(Kit)
RNO: 64030(Kit)
CGE: 100751027(Kit)
NGI: 103734391(Kit)
HGL: 101726400(Kit)
CCAN: 109698965(Kit)
OCU: 100327263(KIT)
TUP: 102489301(KIT)
CFA: 403811(KIT)
AML: 100465243(KIT)
UMR: 103672804(KIT)
ORO: 101372059(KIT)
FCA: 493766(KIT)
PTG: 102960767(KIT)
AJU: 106983989(KIT)
BTA: 280832(KIT)
BOM: 102272986(KIT)
BIU: 109560477(KIT)
PHD: 102329600(KIT)
CHX: 100861386(KIT)
OAS: 780504(KIT)
SSC: 396810(KIT)
CFR: 102521127(KIT)
CDK: 105091541(KIT)
BACU: 102999027(KIT)
LVE: 103070834(KIT)
OOR: 101269214(KIT)
ECB: 100009704(KIT)
EPZ: 103554972(KIT)
EAI: 106839052(KIT)
MYB: 102263655(KIT)
MYD: 102761085(KIT)
HAI: 109381816(KIT)
RSS: 109451718(KIT)
PALE: 102895969(KIT)
LAV: 100655943(KIT)
TMU: 101357486
MDO: 100017501(KIT)
SHR: 100929346(KIT)
OAA: 100075317(KIT)
GGA: 378783(KIT)
MGP: 100542786(KIT)
CJO: 107313766(KIT)
APLA: 101796083(KIT)
ACYG: 106030824(KIT)
TGU: 100221238(KIT)
GFR: 102042215(KIT)
FAB: 101812754(KIT)
PHI: 102103717(KIT)
PMAJ: 107203543(KIT)
CCW: 104690629(KIT)
FPG: 101920758(KIT)
FCH: 102058936(KIT)
CLV: 102095499(KIT)
EGZ: 104129461(KIT)
AAM: 106490087(KIT)
ASN: 102378355(KIT)
AMJ: 102573437(KIT)
PSS: 102451068(KIT)
CMY: 102935862(KIT)
CPIC: 101936545(KIT)
ACS: 100551543(kit)
PVT: 110078419(KIT)
PBI: 103064280(KIT)
GJA: 107106035(KIT)
XLA: 373579(kit.L) 373727(g67.L) 373772(kit.S)
XTR: 100216090(kit)
NPR: 108803804(KIT)
DRE: 30256(kita) 497629(kitb)
IPU: 108258027(kit) 108260969
AMEX: 103022298(kit) 103024973
TRU: 101073765(kit) 101078652
NCC: 104947075(kit) 104968028
MZE: 101472356(kit) 101477603
OLA: 101161964(kit) 101164953
XMA: 102225575(kit) 102237809
PRET: 103463839(kit) 103468941
NFU: 107382191 107393389(kit)
CSEM: 103376706(kit) 103383759
HCQ: 109511237 109532261(kit)
BPEC: 110154760(kit) 110172572
ELS: 105011837(kit) 105020866
SFM: 108922805(kit)
LCM: 102363945(KIT)
CMK: 103178222(kit)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2448137
  Authors
Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U, Ullrich A
  Title
Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.
  Journal
EMBO J 6:3341-51 (1987)
  Sequence
[hsa:3815]
Reference
  Authors
Roskoski R Jr
  Title
Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptor.
  Journal
Biochem Biophys Res Commun 338:1307-15 (2005)
DOI:10.1016/j.bbrc.2005.09.150
Reference
PMID:1698611
  Authors
Nocka K, Buck J, Levi E, Besmer P
  Title
Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors.
  Journal
EMBO J 9:3287-94 (1990)
  Sequence
[mmu:16590]

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