KEGG   ORTHOLOGY: K05091Help
Entry
K05091                      KO                                     

Name
KIT, SCFR, CD117
Definition
proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
Pathway
Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Phospholipase D signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Hematopoietic cell lineage
Melanogenesis
Pathways in cancer
Acute myeloid leukemia
Breast cancer
Central carbon metabolism in cancer
Disease
H00003  
Acute myeloid leukemia (AML)
H00170  
Piebaldism
H01359  
Anaphylaxis
H01511  
Mast-cell leukemia
H01591  
Gastrotintestinal stromal tumor
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   04015 Rap1 signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   04072 Phospholipase D signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   04151 PI3K-Akt signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
  Endocrine system
   04916 Melanogenesis
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   05230 Central carbon metabolism in cancer
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   05221 Acute myeloid leukemia
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   05224 Breast cancer
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  PDGFR family [OT]
   K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
Enzyme-linked receptors [BR:ko01020]
 Receptor tyrosine kinases
  RTK class III (PDGF receptor family)
   K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class III (PDGF receptor family)
   K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
Cellular antigens [BR:ko04090]
 Proteins
  K05091  CD117, KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
BRITE hierarchy
Genes
HSA: 
3815(KIT)
PTR: 
461316(KIT)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
696759(KIT)
MCF: 
CSAB: 
RRO: 
CJC: 
SBQ: 
MMU: 
16590(Kit)
RNO: 
64030(Kit)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
403811(KIT)
AML: 
UMR: 
FCA: 
493766(KIT)
PTG: 
BTA: 
280832(KIT)
BOM: 
PHD: 
CHX: 
OAS: 
780504(KIT)
SSC: 
396810(KIT)
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
LAV: 
MDO: 
SHR: 
OAA: 
GGA: 
378783(KIT)
MGP: 
CJO: 
APLA: 
TGU: 
GFR: 
FAB: 
PHI: 
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
GJA: 
XLA: 
373579(kit.L) 373772(kit.S)
XTR: 
DRE: 
30256(kita) 497629(kitb)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
CMK: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2448137
  Authors
Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U, Ullrich A
  Title
Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.
  Journal
EMBO J 6:3341-51 (1987)
  Sequence
[hsa:3815]
Reference
  Authors
Roskoski R Jr
  Title
Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptor.
  Journal
Biochem Biophys Res Commun 338:1307-15 (2005)
Reference
PMID:1698611
  Authors
Nocka K, Buck J, Levi E, Besmer P
  Title
Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors.
  Journal
EMBO J 9:3287-94 (1990)
  Sequence
[mmu:16590]

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