KEGG   ORTHOLOGY: K05091Help
Entry
K05091                      KO                                     

Name
KIT, SCFR
Definition
proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
Pathway
Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
Hematopoietic cell lineage
Melanogenesis
Pathways in cancer
Acute myeloid leukemia
Central carbon metabolism in cancer
Disease
H00003  
Acute myeloid leukemia (AML)
H00170  
Piebaldism
H01359  
Anaphylaxis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
   04015 Rap1 signaling pathway
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
   04151 PI3K-Akt signaling pathway
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
  Endocrine system
   04916 Melanogenesis
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
   05230 Central carbon metabolism in cancer
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
   05221 Acute myeloid leukemia
    K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  PDGFR family [OT]
   K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
Enzyme-linked receptors [BR:ko01020]
 Receptor tyrosine kinases
  RTK class III (PDGF receptor family)
   K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class III (PDGF receptor family)
   K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit
Cellular antigens [BR:ko04090]
 Proteins
  K05091  CD117, KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
BRITE hierarchy
Genes
HSA: 
3815(KIT)
PTR: 
461316(KIT)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
696759(KIT)
MCF: 
CJC: 
MMU: 
16590(Kit)
RNO: 
64030(Kit)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
403811(KIT)
AML: 
UMR: 
FCA: 
493766(KIT)
PTG: 
BTA: 
280832(KIT)
BOM: 
PHD: 
CHX: 
OAS: 
780504(KIT)
SSC: 
396810(KIT)
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
378783(KIT)
MGP: 
APLA: 
TGU: 
FAB: 
PHI: 
CCW: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
373579(kit-a) 373772(kit-b)
XTR: 
DRE: 
30256(kita) 497629(kitb)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wiesmann C, Muller YA, de Vos AM.
  Title
Ligand-binding sites in Ig-like domains of receptor tyrosine kinases.
  Journal
J Mol Med 78:247-60 (2000)
Reference
  Authors
Roskoski R Jr
  Title
Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptor.
  Journal
Biochem Biophys Res Commun 338:1307-15 (2005)

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