KEGG   ORTHOLOGY: K05093Help
Entry
K05093                      KO                                     

Name
FGFR2, CD332
Definition
fibroblast growth factor receptor 2 [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04810  Regulation of actin cytoskeleton
ko05200  Pathways in cancer
ko05215  Prostate cancer
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
Disease
H00018  Gastric cancer
H00458  Craniosynostosis
H00642  Lacrimo-auriculo-dento-digital syndrome (LADD)
H01753  Antley-Bixler syndrome
H01754  Crouzon syndrome
H01755  Apert syndrome
H01756  Pfeiffer syndrome
H01988  Jackson-Weiss syndrome
H01989  Beare-Stevenson syndrome
H01991  Saethre-Chotzen syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   04015 Rap1 signaling pathway
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   04010 MAPK signaling pathway
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   04151 PI3K-Akt signaling pathway
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
  Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
  Cell motility
   04810 Regulation of actin cytoskeleton
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   05230 Central carbon metabolism in cancer
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   05226 Gastric cancer
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   05215 Prostate cancer
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05093  FGFR2, CD332; fibroblast growth factor receptor 2
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  FGFR family [OT]
   K05093  FGFR2, CD332; fibroblast growth factor receptor 2
CD molecules [BR:ko04090]
 Proteins
  K05093  CD332, FGFR2; fibroblast growth factor receptor 2
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Growth factors/receptors
   K05093  FGFR2, CD332; fibroblast growth factor receptor 2
BRITE hierarchy
Other DBs
GO: 0005007
Genes
HSA: 2263(FGFR2)
PTR: 466220(FGFR2)
PPS: 100981139(FGFR2)
GGO: 101153046(FGFR2)
PON: 100171540(FGFR2)
NLE: 100598157(FGFR2)
MCC: 715949(FGFR2)
MCF: 102143086(FGFR2)
CSAB: 103216628(FGFR2)
RRO: 104675847(FGFR2)
RBB: 108529768(FGFR2)
CJC: 100393573(FGFR2)
SBQ: 101033845(FGFR2)
MMU: 14183(Fgfr2)
RNO: 25022(Fgfr2)
CGE: 100763455(Fgfr2) 107977043
NGI: 103729272(Fgfr2)
HGL: 101709077(Fgfr2)
CCAN: 109691649(Fgfr2)
OCU: 100009417(FGFR2)
TUP: 102484403(FGFR2)
CFA: 415125(FGFR2)
AML: 100468267(FGFR2)
UMR: 103657802(FGFR2)
ORO: 101381278(FGFR2)
FCA: 101095198(FGFR2)
PTG: 102964142(FGFR2)
AJU: 106969379(FGFR2)
BTA: 404193(FGFR2)
BOM: 102270743(FGFR2)
BIU: 109553142(FGFR2)
PHD: 102330293(FGFR2)
CHX: 102170938(FGFR2)
OAS: 443548(FGFR2)
SSC: 396762(FGFR2)
CFR: 102516073(FGFR2)
CDK: 105104060(FGFR2)
BACU: 103012184(FGFR2)
LVE: 103090812(FGFR2)
OOR: 101272068(FGFR2)
ECB: 100033956(FGFR2)
EPZ: 103547114(FGFR2)
EAI: 106846935(FGFR2)
MYB: 102254053(FGFR2)
MYD: 102763283(FGFR2)
HAI: 109383003(FGFR2)
RSS: 109458909(FGFR2)
PALE: 102882899(FGFR2)
TMU: 101357035
MDO: 100025727(FGFR2)
SHR: 100932215(FGFR2)
OAA: 100084628 100084641(FGFR2)
GGA: 396259(FGFR2)
MGP: 100540905
CJO: 107316195(FGFR2)
APLA: 101791540(FGFR2)
ACYG: 106038987(FGFR2)
TGU: 100223379(FGFR2)
GFR: 102038840(FGFR2)
FAB: 101812169(FGFR2)
PHI: 102105117(FGFR2)
PMAJ: 107206911(FGFR2)
CCW: 104694675(FGFR2)
FPG: 101913692(FGFR2)
FCH: 102056102(FGFR2)
CLV: 102091137(FGFR2)
EGZ: 104123669(FGFR2)
AAM: 106499024(FGFR2)
ASN: 102382394(FGFR2)
AMJ: 102564591(FGFR2)
PSS: 102443772(FGFR2)
CMY: 102938554(FGFR2)
CPIC: 101933273(FGFR2)
ACS: 100562611(fgfr2)
PVT: 110075320(FGFR2)
PBI: 103057830(FGFR2)
GJA: 107112647(FGFR2)
XLA: 108697372(fgfr2.S) 399325(fgfr2.L)
XTR: 100124910(fgfr2)
NPR: 108793050(FGFR2)
DRE: 352940(fgfr2)
SANH: 107655670 107679170(fgfr2)
SGH: 107585454 107597642(fgfr2)
IPU: 108263349(fgfr2)
AMEX: 103024961
TRU: 101073665(fgfr2)
LCO: 104925607(fgfr2)
NCC: 104962476
MZE: 101463957(fgfr2)
OLA: 100049483(fgfr2) 101174210
XMA: 102233809
NFU: 107375397(fgfr2)
LCF: 108885762(fgfr2)
HCQ: 109523130(fgfr2)
BPEC: 110168143(fgfr2)
ELS: 105010630(fgfr2)
SFM: 108925828(fgfr2)
LCM: 102349925(FGFR2)
CMK: 103180560 103185425(fgfr2)
DME: Dmel_CG32134(btl)
DSI: Dsimw501_GD14480(Dsim_GD14480)
MDE: 101901067
AME: 413200(htl)
BIM: 100747636
BTER: 100643345
SOC: 105196299
AEC: 105147047
ACEP: 105624923
CFO: 105249959
LHU: 105679827
TCA: 659434(DFR1)
NVL: 108565311
CRG: 105321229
OBI: 106868677
LAK: 106160778
SHX: MS3_01300
AQU: 100633582
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1697263
  Authors
Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J
  Title
Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.
  Journal
EMBO J 9:2685-92 (1990)
  Sequence
[hsa:2263]

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