KEGG   ORTHOLOGY: K05121Help
Entry
K05121                      KO                                     

Name
TEK, TIE2, CD202
Definition
endothelial-specific receptor tyrosine kinase [EC:2.7.10.1]
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04066  HIF-1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko05323  Rheumatoid arthritis
Disease
H00531  Venous malformations
H02044  Cutaneous and mucosal venous malformation
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase
   04015 Rap1 signaling pathway
    K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase
   04010 MAPK signaling pathway
    K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase
   04066 HIF-1 signaling pathway
    K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase
   04151 PI3K-Akt signaling pathway
    K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase
 Human Diseases
  Immune diseases
   05323 Rheumatoid arthritis
    K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases
  TIE family
   K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class XI (TIE receptor family)
   K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase
CD molecules [BR:ko04090]
 Proteins
  K05121  CD202b, TEK; TEK tyrosine kinase, endothelial
BRITE hierarchy
Genes
HSA: 7010(TEK)
PTR: 465028(TEK)
PPS: 100980629(TEK)
GGO: 101153987(TEK)
PON: 100174302(TEK)
NLE: 100606897(TEK)
MCC: 707455(TEK)
MCF: 102122204(TEK)
CSAB: 103219338(TEK)
RRO: 104679005(TEK)
RBB: 108527847(TEK)
CJC: 100408334 103793489(TEK)
SBQ: 101039223(TEK)
MMU: 21687(Tek)
RNO: 89804(Tek)
CGE: 100764854(Tek)
NGI: 103730679(Tek)
HGL: 101710501(Tek)
CCAN: 109675867 109686627(Tek)
OCU: 100356675(TEK)
TUP: 102498017(TEK)
CFA: 403714(TEK)
AML: 100474998(TEK)
UMR: 103667004(TEK)
ORO: 101367636(TEK)
FCA: 101091977(TEK)
PTG: 102954161(TEK)
AJU: 106977825(TEK)
BTA: 280939(TEK)
BOM: 102283049(TEK)
BIU: 109562825(TEK)
PHD: 102329342(TEK)
CHX: 102169100(TEK)
OAS: 497272(TEK)
SSC: 396729(TEK)
CFR: 102510021(TEK)
CDK: 105093613(TEK)
BACU: 103016789(TEK)
LVE: 103068442(TEK)
OOR: 101280154(TEK)
ECB: 100066963(TEK)
EPZ: 103550275(TEK)
EAI: 106838956(TEK)
MYB: 102241735(TEK)
MYD: 102773744(TEK)
HAI: 109388180(TEK)
RSS: 109449728(TEK)
PALE: 102894883(TEK)
LAV: 100656674(TEK)
TMU: 101351895
MDO: 100023250(TEK)
SHR: 100926118
OAA: 100074264(TEK)
GGA: 427368(TEK)
MGP: 100542149(TEK)
CJO: 107306600(TEK)
APLA: 101789714(TEK)
ACYG: 106043732(TEK)
TGU: 100225537(TEK)
GFR: 102042810(TEK)
FAB: 101812140(TEK)
PHI: 102104127(TEK)
PMAJ: 107216128(TEK)
CCW: 104690490(TEK)
FPG: 101910639(TEK)
FCH: 102048724(TEK)
CLV: 102086382(TEK)
EGZ: 104123038(TEK)
AAM: 106486993 106487885(TEK)
ASN: 102376701(TEK)
AMJ: 102559179(TEK)
PSS: 102457133(TEK)
CMY: 102934200(TEK)
CPIC: 101949487(TEK)
ACS: 100558197(tek)
PVT: 110080357(TEK)
PBI: 103054546
GJA: 107116257(TEK)
XLA: 108713943 398263(tek.S)
XTR: 100492432(tek)
NPR: 108787082(TEK)
DRE: 30747(tek)
IPU: 108260272(tek)
AMEX: 103021852(tek)
SASA: 106568558(tek)
ELS: 105020503(tek)
LCM: 102358253(TEK)
CMK: 103178069(tek)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8382358
  Authors
Ziegler SF, Bird TA, Schneringer JA, Schooley KA, Baum PR
  Title
Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta.
  Journal
Oncogene 8:663-70 (1993)
  Sequence
[hsa:7010]
Reference
  Authors
Puri MC, Bernstein A
  Title
Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis.
  Journal
Proc Natl Acad Sci U S A 100:12753-8 (2003)
DOI:10.1073/pnas.2133552100

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