KEGG   ORTHOLOGY: K05357Help
Entry
K05357                      KO                                     

Name
VKORC1
Definition
vitamin-K-epoxide reductase (warfarin-sensitive) [EC:1.17.4.4]
Pathway
ko00130  Ubiquinone and other terpenoid-quinone biosynthesis
ko01110  Biosynthesis of secondary metabolites
Disease
H00995  Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
H01205  Coumarin resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Metabolism of cofactors and vitamins
   00130 Ubiquinone and other terpenoid-quinone biosynthesis
    K05357  VKORC1; vitamin-K-epoxide reductase (warfarin-sensitive)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.17  Acting on CH or CH2 groups
   1.17.4  With a disulfide as acceptor
    1.17.4.4  vitamin-K-epoxide reductase (warfarin-sensitive)
     K05357  VKORC1; vitamin-K-epoxide reductase (warfarin-sensitive)
BRITE hierarchy
Other DBs
RN: R03511 R03645 R09992
GO: 0047057
Genes
HSA: 154807(VKORC1L1) 79001(VKORC1)
PTR: 100610370(VKORC1) 472396(VKORC1L1)
PPS: 100979578(VKORC1L1) 103784246(VKORC1)
GGO: 101127117(VKORC1) 101145443(VKORC1L1)
PON: 100434981(VKORC1) 100458063(VKORC1L1)
NLE: 100591850(VKORC1) 100601157 100601262
MCC: 697591(VKORC1L1) 714412(VKORC1)
MCF: 101926368(VKORC1) 102131386 102142587 102143754
CSAB: 103231221(VKORC1) 103246568(VKORC1L1) 103246572 103246927
RRO: 104661567(VKORC1) 104678399 104678964
RBB: 108527996(VKORC1L1) 108529701(VKORC1)
CJC: 100386573(VKORC1) 100388998(VKORC1L1) 108589856
SBQ: 101041739(VKORC1) 101051522(VKORC1L1)
MMU: 27973(Vkorc1) 69568(Vkorc1l1)
RNO: 103693015 309004(Vkorc1) 399684(Vkorc1l1)
CGE: 100755703(Vkorc1) 100757934(Vkorc1l1)
NGI: 103726327(Vkorc1) 103738949(Vkorc1l1)
HGL: 101708956(Vkorc1l1) 101712053 101712530(Vkorc1)
CCAN: 109682419(Vkorc1)
OCU: 100348035(VKORC1L1) 100352876(VKORC1)
TUP: 102473374(VKORC1L1) 102489609(VKORC1)
CFA: 479775(VKORC1) 606915(VKORC1L1)
AML: 100473818(VKORC1L1) 100476494(VKORC1)
UMR: 103657883(VKORC1) 103670242(VKORC1L1)
ORO: 101365518(VKORC1L1) 101379206(VKORC1)
FCA: 101085010(VKORC1L1) 101089669(VKORC1)
PTG: 102964464(VKORC1) 102969550(VKORC1L1)
AJU: 106972842(VKORC1L1) 106979129(VKORC1)
BTA: 445422(VKORC1)
BOM: 102273264(VKORC1) 102276117(VKORC1L1)
BIU: 109578500(VKORC1)
PHD: 102327090(VKORC1) 102334541(VKORC1L1)
CHX: 102171296(VKORC1) 102174084(VKORC1L1)
OAS: 101108541(VKORC1L1) 105604738(VKORC1)
SSC: 100518062(VKORC1L1) 100522924(VKORC1)
CFR: 102506472(VKORC1L1) 102515335(VKORC1)
CDK: 105089738(VKORC1L1) 105102715(VKORC1)
BACU: 103001696(VKORC1) 103011563(VKORC1L1)
LVE: 103077074(VKORC1) 103091469(VKORC1L1)
OOR: 101271099(VKORC1L1) 101284991(VKORC1)
ECB: 100063360(VKORC1) 100629446(VKORC1L1)
EPZ: 103547239(VKORC1) 103558037(VKORC1L1)
EAI: 106831834(VKORC1L1) 106831891(VKORC1)
MYB: 102239240 102239782(VKORC1) 102255608(VKORC1L1) 102259131
MYD: 102764792(VKORC1L1) 102771765(VKORC1)
HAI: 109374189(VKORC1) 109376915(VKORC1L1)
RSS: 109437819(VKORC1) 109438568(VKORC1L1)
PALE: 102880782(VKORC1L1) 102886750(VKORC1)
LAV: 100663455(VKORC1)
MDO: 100010095(VKORC1L1) 100019247(VKORC1)
SHR: 100914533(VKORC1) 100916214
OAA: 100085063(VKORC1) 103166981(VKORC1L1)
GGA: 404205(VKORC1) 408253(VKORC1L1)
MGP: 100550207(VKORC1L1) 104915861
CJO: 107322449(VKORC1L1)
APLA: 101798787(VKORC1L1)
ACYG: 106041424(VKORC1L1)
TGU: 100230928(VKORC1L1)
GFR: 102033623(VKORC1L1)
FAB: 101810261(VKORC1L1)
PHI: 102104161(VKORC1L1)
PMAJ: 107212753(VKORC1L1)
CCW: 104691083(VKORC1L1)
FPG: 101920959(VKORC1L1)
FCH: 102054510(VKORC1L1)
CLV: 102085852(VKORC1L1)
EGZ: 104131820(VKORC1L1)
AAM: 106495348(VKORC1L1)
ASN: 102373007(VKORC1L1)
AMJ: 102575124(VKORC1L1) 102577367
PSS: 102455189(VKORC1L1) 102455458(VKORC1)
CMY: 102931890(VKORC1L1) 102937112
CPIC: 101932287(VKORC1L1) 101952869(VKORC1) 101953230
ACS: 100555617(vkorc1)
PVT: 110084532(VKORC1L1) 110086404 110086406
PBI: 103052312(VKORC1) 103064445(VKORC1L1)
GJA: 107106645(VKORC1) 107112507(VKORC1L1)
XLA: 108709644(vkorc1l1.S) 398467(LOC398467.L) 733276(vkorc1l1.L)
XTR: 448775(vkorc1) 549523(vkorc1l1)
NPR: 108799191(VKORC1L1) 108800672
DRE: 553717(vkorc1l1)
SANH: 107654009 107654281(vkorc1l1) 107701846
IPU: 100528488(vkorl) 108259877(vkorc1l1)
TRU: 446034(vkorc1) 446035(vkorc1l1)
LCO: 104928769(vkorc1l1) 104935549
NCC: 104956341(vkorc1l1) 104967444
MZE: 101466626 101476827(vkorc1l1)
OLA: 101166326(vkorc1l1) 101175272(vkorc1)
XMA: 102224968 102236035(vkorc1l1)
PRET: 103476055(vkorc1l1) 103481412
NFU: 107387049(vkorc1l1) 107387978
CSEM: 103382040 103394913(vkorc1l1)
LCF: 108884459 108893410(vkorc1l1)
HCQ: 109508799(vkorc1l1) 109524007
BPEC: 110159643 110165064(vkorc1l1)
SASA: 100286492(vkorl) 106567394(vkorc1l1) 106577046
ELS: 105007720 105008282(vkorc1l1)
SFM: 108921596(vkorc1l1) 108938295 108941679
LCM: 102345266(VKORC1L1) 102357927
CMK: 103180624(vkorc1l1)
CIN: 100178185 780870(vkor)
APLC: 110988312
DME: Dmel_CG33544(Vkor)
DSI: Dsimw501_GD11216(Dsim_GD11216)
MDE: 101888998
AAG: 5574649
AME: 724791(Vkor)
BIM: 100746180
BTER: 100647907
SOC: 105199915
AEC: 105148077
ACEP: 105624125
PBAR: 105423896
HST: 105189853
CFO: 105256425
LHU: 105671028
PGC: 109856097
NVI: 100121150
TCA: 103315249
DPA: 109544649
NVL: 108562475
BMOR: 101746818
PMAC: 106717878
PRAP: 111003414
PXY: 105381639
DNX: 107161956
ZNE: 110831183
FCD: 110856806
TUT: 107362817
BMY: Bm1_44490
CRG: 105338127
MYI: 110460140
EPA: 110250868
ADF: 107340505
HMG: 101235337
AQU: 100633778
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Tie JK, Jin DY, Straight DL, Stafford DW
  Title
Functional study of the vitamin K cycle in mammalian cells.
  Journal
Blood 117:2967-74 (2011)
DOI:10.1182/blood-2010-08-304303

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