KEGG   ORTHOLOGY: K05361Help
Entry
K05361                      KO                                     

Name
GPX4
Definition
phospholipid-hydroperoxide glutathione peroxidase [EC:1.11.1.12]
Pathway
ko00480  Glutathione metabolism
ko04216  Ferroptosis
Disease
H01825  Spondylometaphyseal dysplasia, Sedaghatian type (SMDS)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Metabolism of other amino acids
   00480 Glutathione metabolism
    K05361  GPX4; phospholipid-hydroperoxide glutathione peroxidase
 Cellular Processes
  Cell growth and death
   04216 Ferroptosis
    K05361  GPX4; phospholipid-hydroperoxide glutathione peroxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.11  Acting on a peroxide as acceptor
   1.11.1  Peroxidases
    1.11.1.12  phospholipid-hydroperoxide glutathione peroxidase
     K05361  GPX4; phospholipid-hydroperoxide glutathione peroxidase
BRITE hierarchy
Other DBs
RN: R03167
GO: 0047066
Genes
HSA: 2879(GPX4)
PTR: 741876(GPX4)
PPS: 100990361(GPX4)
GGO: 101140897(GPX4)
PON: 100458624(GPX4)
NLE: 100601223(GPX4)
MCC: 705333(GPX4)
MCF: 102142580(GPX4)
CSAB: 103233593(GPX4)
RRO: 104671424(GPX4)
RBB: 108537892(GPX4)
CJC: 100391793(GPX4) 103790339
SBQ: 101053315(GPX4)
MMU: 625249(Gpx4)
RNO: 29328(Gpx4)
CGE: 100765235(Gpx4)
NGI: 103737339(Gpx4)
HGL: 101708875(Gpx4)
CCAN: 109681876(Gpx4)
TUP: 102483947(GPX4)
AML: 100464258(GPX4)
UMR: 103681777(GPX4)
ORO: 101377930(GPX4)
FCA: 101095956(GPX4)
PTG: 102949955(GPX4)
AJU: 106978096(GPX4)
BTA: 286809(GPX4)
BOM: 102284111(GPX4)
BIU: 109561977(GPX4)
PHD: 102324249(GPX4)
CHX: 100860867(GPX4)
OAS: 101113149(GPX4)
SSC: 399537(GPX4)
CFR: 102515650(GPX4)
CDK: 105104118(GPX4)
BACU: 103000913(GPX4)
LVE: 103071491(GPX4)
OOR: 101270118(GPX4)
ECB: 102147383(GPX4)
EAI: 106834230(GPX4)
MYB: 102247160 102257806(GPX4)
MYD: 102758267(GPX4)
HAI: 109390605
RSS: 109453931(GPX4)
PALE: 102878189(GPX4)
LAV: 100675152(GPX4)
TMU: 101355012
MDO: 100015749(GPX4)
SHR: 100930158(GPX4)
OAA: 100088643(GPX4)
GGA: 374056(GPX4)
MGP: 100379155(GPX4)
CJO: 107325473(GPX4)
APLA: 101796330(GPX4)
ACYG: 106048194(GPX4)
TGU: 100190423(GPX4)
GFR: 102045367(GPX4)
FAB: 101817765(GPX4)
PHI: 102113402(GPX4)
PMAJ: 107215549(GPX4)
CCW: 104697013(GPX4)
FPG: 101916317(GPX4)
FCH: 102055857(GPX4)
CLV: 102092188(GPX4)
EGZ: 104127393(GPX4)
AAM: 106493531(GPX4)
ASN: 102386897(GPX4)
AMJ: 102570581(GPX4)
PSS: 102460999(GPX4)
CMY: 102948400(GPX4)
CPIC: 101944764(GPX4)
ACS: 100563257(gpx4)
PVT: 110079257(GPX4)
PBI: 103065827(GPX4)
GJA: 107107351(GPX4)
XLA: 100036920(gpx4.L) 734888(gpx4.S)
XTR: 100496541(gpx4)
NPR: 108789489(GPX4)
DRE: 352928(gpx4a) 352929(gpx4b)
SANH: 107660382
SGH: 107552704
IPU: 100528418(gpx4)
AMEX: 103026361(gpx4)
TRU: 101066389 101070699(gpx4)
LCO: 104929635 104930512(gpx4)
NCC: 104958153(gpx4)
MZE: 101475014 101481366(gpx4)
XMA: 102218769 102219707(gpx4)
PRET: 103463715(gpx4) 103479268
NFU: 107384121 107393348(gpx4)
CSEM: 103376758(gpx4) 103395914
BPEC: 110157283 110174007(gpx4)
SASA: 100194734(gpx4b) 106573579
SFM: 108919780(gpx4) 108921631
CMK: 103189927(gpx4)
CIN: 100175675(gpx_e)
SPU: 100891322
APLC: 110989974
SKO: 102807044
AME: 726269(Gtpx2)
BIM: 100743362
BTER: 100648859
SOC: 105193617
ACEP: 105625818
PBAR: 105425460
HST: 105183432
CFO: 105248391
LHU: 105668639
PGC: 109853223
NVI: 100114603
DPA: 109546481
PMAC: 106708689
TUT: 107368679
CRG: 105330305
MYI: 110445160
ADF: 107353881
HMG: 100212361 100215761(GPx)
SPAR: SPRG_01802
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8323565
  Authors
Sunde RA, Dyer JA, Moran TV, Evenson JK, Sugimoto M
  Title
Phospholipid hydroperoxide glutathione peroxidase: full-length pig blastocyst cDNA sequence and regulation by selenium status.
  Journal
Biochem Biophys Res Commun 193:905-11 (1993)
DOI:10.1006/bbrc.1993.1711
  Sequence
[ssc:399537]

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