KEGG   ORTHOLOGY: K05405Help
Entry
K05405                      KO                                     

Name
IL6
Definition
interleukin 6
Pathway
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
FoxO signaling pathway
PI3K-Akt signaling pathway
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Cytosolic DNA-sensing pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
TNF signaling pathway
Intestinal immune network for IgA production
Non-alcoholic fatty liver disease (NAFLD)
Prion diseases
Salmonella infection
Pertussis
Legionellosis
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Malaria
Amoebiasis
Tuberculosis
Hepatitis B
Measles
Influenza A
HTLV-I infection
Herpes simplex infection
Pathways in cancer
Transcriptional misregulation in cancer
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
Graft-versus-host disease
Hypertrophic cardiomyopathy (HCM)
Disease
H00084  
Graft-versus-host disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K05405  IL6; interleukin 6
   04668 TNF signaling pathway
    K05405  IL6; interleukin 6
   04066 HIF-1 signaling pathway
    K05405  IL6; interleukin 6
   04068 FoxO signaling pathway
    K05405  IL6; interleukin 6
   04151 PI3K-Akt signaling pathway
    K05405  IL6; interleukin 6
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05405  IL6; interleukin 6
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K05405  IL6; interleukin 6
   04620 Toll-like receptor signaling pathway
    K05405  IL6; interleukin 6
   04621 NOD-like receptor signaling pathway
    K05405  IL6; interleukin 6
   04623 Cytosolic DNA-sensing pathway
    K05405  IL6; interleukin 6
   04672 Intestinal immune network for IgA production
    K05405  IL6; interleukin 6
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05405  IL6; interleukin 6
   05202 Transcriptional misregulation in cancers
    K05405  IL6; interleukin 6
  Immune diseases
   05323 Rheumatoid arthritis
    K05405  IL6; interleukin 6
   05321 Inflammatiory bowel disease (IBD)
    K05405  IL6; interleukin 6
   05332 Graft-versus-host disease
    K05405  IL6; interleukin 6
  Neurodegenerative diseases
   05020 Prion diseases
    K05405  IL6; interleukin 6
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K05405  IL6; interleukin 6
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K05405  IL6; interleukin 6
  Infectious diseases
   05132 Salmonella infection
    K05405  IL6; interleukin 6
   05133 Pertussis
    K05405  IL6; interleukin 6
   05134 Legionellosis
    K05405  IL6; interleukin 6
   05152 Tuberculosis
    K05405  IL6; interleukin 6
   05166 HTLV-I infection
    K05405  IL6; interleukin 6
   05162 Measles
    K05405  IL6; interleukin 6
   05164 Influenza A
    K05405  IL6; interleukin 6
   05161 Hepatitis B
    K05405  IL6; interleukin 6
   05168 Herpes simplex infection
    K05405  IL6; interleukin 6
   05146 Amoebiasis
    K05405  IL6; interleukin 6
   05144 Malaria
    K05405  IL6; interleukin 6
   05142 Chagas disease (American trypanosomiasis)
    K05405  IL6; interleukin 6
   05143 African trypanosomiasis
    K05405  IL6; interleukin 6
Cytokines [BR:ko04052]
 Class I cytokines (hematopoietin family)
  IL-6 receptor family
   K05405  IL6; interleukin 6
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
3569(IL6)
PTR: 
463288(IL6)
PPS: 
GGO: 
PON: 
MCC: 
705819(IL6)
MCF: 
MMU: 
16193(Il6)
RNO: 
24498(Il6)
CGE: 
HGL: 
TUP: 
CFA: 
403985(IL6)
AML: 
FCA: 
493687(IL6)
PTG: 
BTA: 
280826(IL6)
BOM: 
PHD: 
CHX: 
OAS: 
443406(IL6)
SSC: 
100628202(IL-6) 399500(IL6)
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
OAA: 
GGA: 
395337(IL6)
MGP: 
APLA: 
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
PBI: 
XTR: 
DRE: 
TRU: 
503562(il-6)
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Fonseca JE, Santos MJ, Canhao H, Choy E
  Title
Interleukin-6 as a key player in systemic inflammation and joint destruction.
  Journal
Autoimmun Rev 8:538-42 (2009)
Reference
  Authors
White UA, Stephens JM
  Title
The gp130 receptor cytokine family: regulators of adipocyte development and function.
  Journal
Curr Pharm Des 17:340-6 (2011)

DBGET integrated database retrieval system