KEGG   ORTHOLOGY: K05410Help
Entry
K05410                      KO                                     

Name
TBK1
Definition
TANK-binding kinase 1 [EC:2.7.11.10]
Pathway
Ras signaling pathway
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Cytosolic DNA-sensing pathway
Hepatitis C
Hepatitis B
Measles
Influenza A
Herpes simplex infection
Epstein-Barr virus infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05410  TBK1; TANK-binding kinase 1
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K05410  TBK1; TANK-binding kinase 1
   04622 RIG-I-like receptor signaling pathway
    K05410  TBK1; TANK-binding kinase 1
   04623 Cytosolic DNA-sensing pathway
    K05410  TBK1; TANK-binding kinase 1
 Human Diseases
  Infectious diseases
   05162 Measles
    K05410  TBK1; TANK-binding kinase 1
   05164 Influenza A
    K05410  TBK1; TANK-binding kinase 1
   05161 Hepatitis B
    K05410  TBK1; TANK-binding kinase 1
   05160 Hepatitis C
    K05410  TBK1; TANK-binding kinase 1
   05168 Herpes simplex infection
    K05410  TBK1; TANK-binding kinase 1
   05169 Epstein-Barr virus infection
    K05410  TBK1; TANK-binding kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     K05410  TBK1; TANK-binding kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: Other group
  IKK family [OT]
   K05410  TBK1; TANK-binding kinase 1
BRITE hierarchy
Genes
HSA: 
29110(TBK1)
PTR: 
452047(TBK1)
PPS: 
100990211(TBK1)
GGO: 
101138038(TBK1)
PON: 
100433568(TBK1)
MCC: 
717427(TBK1)
MCF: 
102144774(TBK1)
MMU: 
56480(Tbk1)
RNO: 
299827(Tbk1)
CGE: 
HGL: 
101713766(Tbk1)
TUP: 
102484078(TBK1)
CFA: 
481145(TBK1)
AML: 
100484104(TBK1)
FCA: 
101091955(TBK1)
PTG: 
102960158(TBK1)
BTA: 
533141(TBK1)
BOM: 
102279479(TBK1)
PHD: 
102341504(TBK1)
CHX: 
102181474(TBK1)
SSC: 
100125828(TBK1)
CFR: 
102514948(TBK1)
ECB: 
100051650(TBK1)
MYB: 
102241250(TBK1)
MYD: 
102769631(TBK1)
PALE: 
102878859(TBK1)
SHR: 
100915362(TBK1)
OAA: 
100076520(TBK1)
GGA: 
417825(TBK1)
MGP: 
TGU: 
100225715(TBK1)
FAB: 
101809300(TBK1)
PHI: 
102112102(TBK1)
APLA: 
101800085(TBK1)
FPG: 
101911068(TBK1)
FCH: 
102051211(TBK1)
CLV: 
102085310(TBK1)
ASN: 
102383892(TBK1)
PSS: 
102457979(TBK1)
CMY: 
102938424(TBK1)
ACS: 
100553575(tbk1)
XLA: 
446351(tbk1)
XTR: 
100216212(tbk1)
DRE: 
692289(tbk1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102356087(TBK1)
BFO: 
CIN: 
778650(ikk-epsilon) 780713(ikk-epsilon)
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
413493(ik2)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
BMY: 
LOA: 
NVE: 
HMG: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Pomerantz JL, Baltimore D
  Title
NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase.
  Journal
EMBO J 18:6694-704 (1999)
Reference
  Authors
Kishore N, Huynh QK, Mathialagan S, Hall T, Rouw S, Creely D, Lange G, Caroll J, Reitz B, Donnelly A, Boddupalli H, Combs RG, Kretzmer K, Tripp CS
  Title
IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2.
  Journal
J Biol Chem 277:13840-7 (2002)

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