KEGG   ORTHOLOGY: K05425Help
Entry
K05425                      KO                                     

Name
IL12B
Definition
interleukin 12B
Pathway
Cytokine-cytokine receptor interaction
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Jak-STAT signaling pathway
Th1 and Th2 cell differentiation
Type I diabetes mellitus
Pertussis
Legionellosis
Leishmaniasis
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Toxoplasmosis
Amoebiasis
Tuberculosis
Measles
Influenza A
Herpes simplex infection
Proteoglycans in cancer
Inflammatory bowel disease (IBD)
Allograft rejection
Disease
H00089  
IFN-gamma/IL-12 axis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K05425  IL12B; interleukin 12B
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05425  IL12B; interleukin 12B
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K05425  IL12B; interleukin 12B
   04622 RIG-I-like receptor signaling pathway
    K05425  IL12B; interleukin 12B
   04658 Th1 and Th2 cell differentiation
    K05425  IL12B; interleukin 12B
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    K05425  IL12B; interleukin 12B
  Immune diseases
   05321 Inflammatiory bowel disease (IBD)
    K05425  IL12B; interleukin 12B
   05330 Allograft rejection
    K05425  IL12B; interleukin 12B
  Endocrine and metabolic diseases
   04940 Type I diabetes mellitus
    K05425  IL12B; interleukin 12B
  Infectious diseases
   05133 Pertussis
    K05425  IL12B; interleukin 12B
   05134 Legionellosis
    K05425  IL12B; interleukin 12B
   05152 Tuberculosis
    K05425  IL12B; interleukin 12B
   05162 Measles
    K05425  IL12B; interleukin 12B
   05164 Influenza A
    K05425  IL12B; interleukin 12B
   05168 Herpes simplex infection
    K05425  IL12B; interleukin 12B
   05146 Amoebiasis
    K05425  IL12B; interleukin 12B
   05145 Toxoplasmosis
    K05425  IL12B; interleukin 12B
   05140 Leishmaniasis
    K05425  IL12B; interleukin 12B
   05142 Chagas disease (American trypanosomiasis)
    K05425  IL12B; interleukin 12B
   05143 African trypanosomiasis
    K05425  IL12B; interleukin 12B
Cytokines [BR:ko04052]
 Class I cytokines (hematopoietin family)
  IL-6 receptor family
   K05425  IL12B; interleukin 12B
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Cytokines
   K05425  IL12B; interleukin 12B
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
3593(IL12B)
PTR: 
471723(IL12B)
PPS: 
100989950(IL12B)
GGO: 
101141274(IL12B)
PON: 
100435254(IL12B)
NLE: 
100579267(IL12B)
MCC: 
694747(IL12B)
MCF: 
102124858(IL12B)
CSAB: 
103244892(IL12B)
RRO: 
104669104(IL12B)
CJC: 
100395403(IL12B)
SBQ: 
101049311(IL12B)
MMU: 
16160(Il12b)
RNO: 
64546(Il12b)
CGE: 
100764758(Il12b)
NGI: 
103724546(Il12b)
HGL: 
101701309(Il12b)
OCU: 
100354852(IL12B)
TUP: 
102499876(IL12B)
CFA: 
403976(IL12B)
AML: 
100477772(IL12B)
UMR: 
103664531(IL12B)
FCA: 
768273(IL12B)
PTG: 
102959546(IL12B)
BTA: 
281857(IL12B)
BOM: 
102283689(IL12B)
PHD: 
102341688(IL12B)
CHX: 
100860845(IL12B)
OAS: 
443472(IL12B)
SSC: 
397076(IL12B)
CFR: 
102515488(IL12B)
BACU: 
103007028(IL12B)
LVE: 
103083704(IL12B)
ECB: 
100034222(IL12B)
MYB: 
102253394(IL12B)
MYD: 
102756968(IL12B)
PALE: 
102884214(IL12B)
LAV: 
100657211(IL12B)
MDO: 
100030276(IL12B)
SHR: 
100932486(IL12B)
OAA: 
100074930(IL12B)
GGA: 
404671(IL12B)
MGP: 
100303696(IL12B)
CJO: 
107320334(IL12B)
APLA: 
101800211(IL12B)
TGU: 
100217488(IL12B)
GFR: 
102044384(IL12B)
FAB: 
101814108(IL12B)
PHI: 
102100856(IL12B)
CCW: 
104689490(IL12B)
FPG: 
101920686(IL12B)
FCH: 
102046968(IL12B)
CLV: 
102097579(IL12B)
AAM: 
106493613(IL12B)
ASN: 
102379831(IL12B)
AMJ: 
PSS: 
102449025(IL12B)
CMY: 
102939116(IL12B)
ACS: 
103277860(il12b)
XTR: 
105946920(il12b)
DRE: 
445373(il12ba)
TRU: 
101066952 101077588 445913(IL-12_p40) 445964(il12b)
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
102348110(IL12B)
CMK: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1674604
  Authors
Gubler U, Chua AO, Schoenhaut DS, Dwyer CM, McComas W, Motyka R, Nabavi N, Wolitzky AG, Quinn PM, Familletti PC, et al.
  Title
Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.
  Journal
Proc Natl Acad Sci U S A 88:4143-7 (1991)
  Sequence
[hsa:3593]
Reference
  Authors
Klinke DJ 2nd
  Title
A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12.
  Journal
Mol Cancer 9:242 (2010)

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